Highly Enantioselective Construction of Strained Spiro[2,3]hexanes through a Michael Addition/Ring Expansion/Cyclization Cascade

Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

(2019) Peng-Wei Xu et al.   ACS Catalysis

General Cyclopropane Assembly by Enantioselective Transfer of a Redox-Active Carbene to Aliphatic Olefins

(2019) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydroalkylation of Olefins To Form Quaternary Carbons

(2019) Samantha A. Green et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Streamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis

(2019) Nils J. Flodén et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Profiling the Privileges of Pyrrolidine-Based Catalysts in Asymmetric Synthesis - from Polar to Light-Driven Radical Chemistry

(2019) Alberto Vega Penaloza et al.   ACS Catalysis

N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles

(2019) Zi-Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters

(2019) Hua Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbene-Catalyzed Desymmetrization and Direct Construction of Arenes with All-Carbon Quaternary Chiral Center

(2019) Tingshun Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual C(sp3 )−H Bond Functionalization of N-Heterocycles through Sequential Visible-Light Photocatalyzed Dehydrogenation/[2+2] Cycloaddition Reactions

(2018) Guo-Qiang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds

(2017) Lei Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-light excitation of iminium ions enables the enantioselective catalytic β-alkylation of enals

(2017) Mattia Silvi et al.   Nature Chemistry

Highly Enantioselective Construction of Hajos–Wiechert Ketone Skeletons via an Organocatalytic Vinylogous Michael/Stetter Relay Sequence

(2017) Zhi-Long Jia et al.   ORGANIC LETTERS

Quaternary Carbon Center Forming Formal [3 + 3] Cycloaddition Reaction via Bifunctional Catalysis: Asymmetric Synthesis of Spirocyclohexene Pyrazolones

(2017) Jin-Yu Liu et al.   ORGANIC LETTERS

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals

(2016) John J. Murphy et al.   NATURE

Magical Chiral Spiro Ligands

(2015) Jianhua Xie et al.   ACTA CHIMICA SINICA

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A catalytic asymmetric hetero-Diels–Alder reaction of olefinic azlactones and isatins: facile access to chiral spirooxindole dihydropyranones

(2014) Tai-Ping Gao et al.   CHEMICAL COMMUNICATIONS

Metal Complex Catalysis in the Synthesis of Spirocarbocycles

(2014) Vladimir A. D’yakonov et al.   CHEMICAL REVIEWS

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Intramolecular donor–acceptor cyclopropane ring-opening cyclizations

(2013) Marchello A. Cavitt et al.   CHEMICAL SOCIETY REVIEWS

Hydrogen-Bond-Mediated Supramolecular Iminium Ion Catalysis

(2012) Yao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclobutane-Derived Diamines: Synthesis and Molecular Structure

(2010) Dmytro S. Radchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Heterocycles from cyclopropanes: applications in natural product synthesis

(2009) Cheryl A. Carson et al.   CHEMICAL SOCIETY REVIEWS

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE