Pd/Cu-Catalyzed Enantioselective Sequential Heck/Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers

Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications

(2019) Huaanzi Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions

(2018) Yuanyuan Ping et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Asymmetric Allylic Alkylations of Colby Pro-Enolates with MBH Carbonates: Enantioselective Access to Quaternary C−F Oxindoles

(2018) Yi Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Synthesis of Dihydrobenzoindolones via C–H Bond Activation and Alkyne Insertion

(2018) José F. Rodríguez et al.   ORGANIC LETTERS

Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners

(2018) Jing Yang et al.   Catalysts

Cu-Catalyzed tertiary alkylation of α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents

(2018) Wenpeng Dai et al.   Organic Chemistry Frontiers

Carboiodination Catalyzed by Nickel

(2018) Hyung Yoon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Taming Radical Intermediates for the Construction of Enantioenriched Trifluoromethylated Quaternary Carbon Centers

(2018) Roxan Calvo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes

(2018) De-Long Kong et al.   MOLECULES

Erythrosine B Catalyzed Visible-Light Photoredox Arylation-Cyclization of N -Alkyl-N -aryl-2-(trifluoromethyl)acrylamides to 3-(Trifluoromethyl)indolin-2-one Derivatives

(2017) Zsombor Gonda et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed, Enantioselective α-Arylation of α-Fluorooxindoles

(2017) Yushu Jin et al.   ORGANIC LETTERS

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Catalytic Enantioselective and Diastereoselective Allylic Alkylation with Fluoroenolates: Efficient Access to C3-Fluorinated and All-Carbon Quaternary Oxindoles

(2016) Kaluvu Balaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Enantioselective Copper(I)-Catalyzed Intermolecular [3+2] Cycloaddition of Azomethine Ylides with β-Trifluoromethyl β,β-Disubstituted Enones

(2016) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

(2016) Bin Yu et al.   Beilstein Journal of Organic Chemistry

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Pd-Catalyzed Spirocyclization via C–H Activation and Benzyne Insertion

(2016) Hyung Yoon et al.   ORGANIC LETTERS

Enantioselective synthesis of 3-fluoro-3-allyl-oxindoles via phosphine-catalyzed asymmetric γ-addition of 3-fluoro-oxindoles to 2,3-butadienoates

(2015) Tianli Wang et al.   CHEMICAL COMMUNICATIONS

Domino Heck/borylation sequence towards indolinone-3-methyl boronic esters: trapping of the σ-alkylpalladium intermediate with boron

(2015) Dipak D. Vachhani et al.   CHEMICAL COMMUNICATIONS

Palladium-catalyzed allylation of trifluoromethylated ketene aminoacetals

(2015) Wengui Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole

(2015) Wangqing Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double CF Bond Activation through β-Fluorine Elimination: Nickel-Mediated [3+2] Cycloaddition of 2-Trifluoromethyl-1-alkenes with Alkynes

(2014) Tomohiro Ichitsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-Catalyzed Enantioselective γ-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles

(2014) Tianli Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkylation of Terminal Alkynes with Transient σ-Alkylpalladium(II) Complexes: A Carboalkynylation Route to Alkyl-Substituted Alkynes

(2014) Ming-Bo Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

3D QSAR based design of novel oxindole derivative as 5HT7inhibitors

(2014) Aparna Chitta et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Diverse reactivity in microwave-promoted catalyst-free coupling of substituted anilines with ethyl trifluoropyruvate and biological evaluation

(2013) Chen Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective conjugate addition of 3-fluoro-oxindoles to vinyl sulfone: an organocatalytic access to chiral 3-fluoro-3-substituted oxindoles

(2013) Xiaowei Dou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides

(2012) Linglin Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles

(2012) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Synthesis of Trifluoromethyl-substituted Diarylpyrrolines: Enantioselective Conjugate Cyanation of β-Aryl-β-trifluoromethyl-disubstituted Enones

(2012) Hiroyuki Kawai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of a C(sp3)H Bond by a Transient σ-Alkylpalladium(II) Complex: Synthesis of Spirooxindoles Through a Palladium-Catalyzed Domino Carbopalladation/C(sp3)C(sp3) Bond-Forming Process

(2012) Tiffany Piou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Structure-Activity Relationships of Organofluorine Inhibitors of β-Amyloid Self-Assembly

(2012) Béla Török et al.   ChemMedChem

Highly Enantioselective Copper-Catalyzed Electrophilic Trifluoromethylation of β-Ketoesters

(2012) Qing-Hai Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The asymmetric Heck and related reactions

(2011) Dennis Mc Cartney et al.   CHEMICAL SOCIETY REVIEWS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Optimization of (Arylpiperazinylbutyl)oxindoles Exhibiting Selective 5-HT7Receptor Antagonist Activity

(2011) Balázs Volk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors

(2008) P Malherbe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis ofgem-Difluoroalkenes via β-Fluoride Elimination of Organorhodium(I)

(2008) Tomoya Miura et al.   CHEMISTRY LETTERS

(Phenylpiperazinyl-butyl)oxindoles as Selective 5-HT7Receptor Antagonists

(2008) Balázs Volk et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-HT6/7 Receptor Antagonists Facilitate Dopamine Release in the Cochlea via a GABAergic Disinhibitory Mechanism

(2008) Zoltán Doleviczényi et al.   NEUROCHEMICAL RESEARCH

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS