期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 7, 页码 2695-2699出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914264
关键词
mRNA delivery; nanomaterials; nanoregulators; organosilica
资金
- ARC [DP200102962]
- Australian Research Council
- Queensland Government
- Australian National Fabrication Facility at the Centre for Microscopy and Microanalysis
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
- University of Queensland
- Australian Research Council [DP200102962] Funding Source: Australian Research Council
Effective messenger RNA (mRNA) transfection in hard-to-transfect cells delivered by vectors is a long-standing challenge. Now it is hypothesized that the high intracellular glutathione level is associated with suppressed mRNA translation. This theory leads to a new design principle of next-generation mRNA vectors: nanoparticles with glutathione depletion chemistry upregulate mRNA translation and enhance transfection, which is beneficial for mRNA delivery in hard-to-transfect cells in vitro and in vivo.
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