Sequence-Dependent Stereodivergent Allylic Alkylation/Fluorination of Acyclic Ketones

Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters

(2019) Ransheng Ding et al.   ACS Catalysis

Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates

(2019) Bei-Bei Yue et al.   ORGANIC LETTERS

Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates

(2019) Chun-Yan Meng et al.   ORGANIC LETTERS

Ketones and Aldehydes as O-Nucleophiles in Iridium-Catalyzed Intramolecular Asymmetric Allylic Substitution Reaction

(2019) Ye Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Synthesis of α-Trifluoromethyl Homoallylic Amines via Umpolung Allylation/2-Aza-Cope Rearrangement: Stereoselectivity and Mechanistic Insight

(2019) Li-Min Shi et al.   ORGANIC LETTERS

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands

(2019) Simon L. Rössler et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

(2019) Zhi-Tao He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles

(2019) Tobias Sandmeier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective construction of remote tertiary carbon–fluorine bonds

(2019) Jianbo Liu et al.   Nature Chemistry

Enantioselective Direct Vinylogous Allylic Alkylation of 4-Methylquinolones under Iridium Catalysis

(2019) Rahul Sarkar et al.   ORGANIC LETTERS

Highly Regio- and Stereodivergent Access to 1,2-Amino Alcohols or 1,4-Fluoro Alcohols by NHC-Catalyzed Ring Opening of Epoxy enals

(2018) Si Bei Poh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzylic Fluorination of Aza-Heterocycles Induced by Single-Electron Transfer to Selectfluor

(2018) Kelley E. Danahy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Vicinal All-Carbon Quaternary Centers via Iridium-Catalyzed Allylic Alkylation

(2018) J. Caleb Hethcox et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation and Application of (Diborylmethyl)zinc(II) Species: Access to Enantioenriched gem-Diborylalkanes by an Asymmetric Allylic Substitution

(2018) Yeosan Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Asymmetric C(sp3 )−H Allylation of 2-Alkylpyridines

(2018) Ryo Murakami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation

(2018) Yeshua Sempere et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

(2018) Yi Zhu et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Asymmetric Allylic Alkylations of Colby Pro-Enolates with MBH Carbonates: Enantioselective Access to Quaternary C−F Oxindoles

(2018) Yi Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereoselective and Enantioselective Palladium-Catalyzed Allylic Substitution of Substituted Fluorinated Methylene Derivatives

(2018) Tao Song et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

(2018) Liang Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

(2018) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

(2018) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives

(2018) Michael Meanwell et al.   Chemical Science

Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

(2018) Rahul Sarkar et al.   Chemical Science

Enantioselective Synthesis of Tertiary Allylic Fluorides by Iridium-Catalyzed Allylic Fluoroalkylation

(2018) Trevor W. Butcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Enantioselective Csp3–Csp3 Cross-Coupling for the Synthesis of (Poly)fluorinated Chiral Building Blocks

(2018) Yanhui Lu et al.   ORGANIC LETTERS

Intermolecular Stereoselective Iridium-Catalyzed Allylic Alkylation: An Evolutionary Account

(2018) Brian Stoltz et al.   SYNLETT

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2018) Qiang Cheng et al.   CHEMICAL REVIEWS

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

(2018) Seung Wook Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Catalytic Enantioselective Benzylation from Aryl Acetic Acids

(2018) Patrick J. Moon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diasteroselective and Enantioselective Ir-Catalyzed Allylic Substitutions of 1-Substituted 1-Fluoro-1-(arenesulfonyl)methylene Derivatives

(2017) Jiteng Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex

(2017) James Y. Hamilton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective and Diastereoselective Allylic Alkylation with Fluoroenolates: Efficient Access to C3-Fluorinated and All-Carbon Quaternary Oxindoles

(2016) Kaluvu Balaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Stereoselective Allylic Alkylation Reactions with Crotyl Chloride

(2016) J. Caleb Hethcox et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Diastereoselective and Enantioselective Allylic Substitutions with Acyclic α-Alkoxy Ketones

(2016) Xingyu Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N -Fluorobenzenesulfonimide

(2016) Michael Meanwell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Synthesis of chiral fluorine-containing compounds via Pd-catalyzed asymmetrical allylations of dimethyl 2-fluoromalonate using sulfonamide-pyridine ligands

(2016) Min Zhang et al.   JOURNAL OF FLUORINE CHEMISTRY

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

(2016) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis

(2016) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective synthesis of fluorinated branched allylic compounds via Ir-catalyzed allylations of functionalized fluorinated methylene derivatives

(2016) Hongbo Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iridium-Catalyzed Diastereo-, Enantio-, and Regioselective Allylic Alkylation with Prochiral Enolates

(2016) J. Caleb Hethcox et al.   ACS Catalysis

Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

(2016) Mayaka Maeno et al.   RSC Advances

Nickel-Catalyzed Allylic Alkylation with Diarylmethane Pronucleophiles: Reaction Development and Mechanistic Insights

(2015) Sheng-Chun Sha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes

(2015) Tobias Sandmeier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric γ-Allylation of α,β-Unsaturated Aldehydes by Combined Organocatalysis and Transition-Metal Catalysis

(2015) Line Naesborg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles

(2015) Xiao Zhang et al.   Chemical Science

Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

(2014) Ying Huang et al.   CHEMICAL COMMUNICATIONS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Pd-Catalyzed Allylation of Acyclic α-Fluorinated Ketones

(2014) Wengui Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Iridium-Catalyzed Allylation of Cyclic Ketone Enolates: Synergetic Effect of Ligands and Barium Enolates

(2014) Wenyong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

(2014) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

(2014) Corey M. Reeves et al.   ORGANIC LETTERS

Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters

(2013) Lin Yan et al.   Beilstein Journal of Organic Chemistry

Raising the pKa Limit of “Soft” Nucleophiles in Palladium-Catalyzed Allylic Substitutions: Application of Diarylmethane Pronucleophiles

(2013) Sheng-Chun Sha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters via Ir-Catalyzed Regio-, Diastereo-, and Enantioselective Allylic Alkylation and Applications in Sequential Pd Catalysis

(2013) Wen-Bo Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Functionalization of Indoles and Pyrroles via an in Situ-Formed Spiro Intermediate

(2013) Chun-Xiang Zhuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of Diastereoselectivity for Iridium-Catalyzed Allylation of a Prochiral Nucleophile with a Phosphate Counterion

(2013) Wenyong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantio-, Diastereo-, and Regioselective Iridium-Catalyzed Asymmetric Allylic Alkylation of Acyclic β-Ketoesters

(2013) Wen-Bo Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cation Control of Diastereoselectivity in Iridium-Catalyzed Allylic Substitutions. Formation of Enantioenriched Tertiary Alcohols and Thioethers by Allylation of 5H-Oxazol-4-ones and 5H-Thiazol-4-ones

(2013) Wenyong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantio- and Diastereodivergent Dual Catalysis:  -Allylation of Branched Aldehydes

(2013) S. Krautwald et al.   SCIENCE

Iridium-Catalyzed Allylic Alkylation Reaction with N-Aryl Phosphoramidite Ligands: Scope and Mechanistic Studies

(2012) Wen-Bo Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Applications of Potential Substitutes of t-Bu-Phosphinooxazoline in Pd-Catalyzed Asymmetric Transformations and Their Use for the Improvement of the Enantioselectivity in the Pd-Catalyzed Allylation Reaction of Fluorinated Allyl Enol Carbonates

(2011) Étienne Bélanger et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams

(2011) Douglas C. Behenna et al.   Nature Chemistry

Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution

(2010) John F. Hartwig et al.   ACCOUNTS OF CHEMICAL RESEARCH

Iridium-catalyzed regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane

(2009) Wen-Bo Liu et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Regio-, Diastereo-, and Enantioselective Benzylic Allylation of 2-Substituted Pyridines

(2009) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected effect of the fluorine atom on the optimal ligand-to-palladium ratio in the enantioselective Pd-catalyzed allylation reaction of fluorinated enol carbonates

(2008) Étienne Bélanger et al.   CHEMICAL COMMUNICATIONS

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

Strategy for Employing Unstabilized Nucleophiles in Palladium-Catalyzed Asymmetric Allylic Alkylations

(2008) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY