Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

Contrasting genetic architectures in different mouse reference populations used for studying complex traits

(2015) David A. Buchner et al.   GENOME RESEARCH

NOD mice are functionally deficient in the capacity of cross-presentation

(2015) Chin-Nien Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

Induction of interleukin-1 beta (IL-1β) is a critical component of lung inflammation during influenza A (H1N1) virus infection

(2015) Kwang Seok Kim et al.   JOURNAL OF MEDICAL VIROLOGY

Protection from Severe Influenza Virus Infections in Mice Carrying theMx1Influenza Virus Resistance Gene Strongly Depends on Genetic Background

(2015) Dai-Lun Shin et al.   JOURNAL OF VIROLOGY

Host genes and influenza pathogenesis in humans: an emerging paradigm

(2015) Kelvin Kai-Wang To et al.   Current Opinion in Virology

Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points

(2014) Karin Vered et al.   BMC GENOMICS

Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

(2014) Ivan K. H. Poon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung

(2014) H. Rutledge et al.   GENETICS

Structural Requirements for the Antiviral Activity of the Human MxA Protein against Thogoto and Influenza A Virus

(2014) Corinna Patzina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Absence of Lymphoid CD8+ Dendritic Cell Maturation in L-Selectin-/- Respiratory Compartment Attenuates Antiviral Immunity

(2014) D. W. Pascual et al.   JOURNAL OF IMMUNOLOGY

Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus

(2014) C. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Sex, Immunity and Influenza

(2014) G. Gabriel et al.   JOURNAL OF INFECTIOUS DISEASES

The Collaborative Cross as a Resource for Modeling Human Disease: CC011/Unc, a New Mouse Model for Spontaneous Colitis

(2014) Allison R. Rogala et al.   MAMMALIAN GENOME

Heritability and coefficient of genetic variation analyses of phenotypic traits provide strong basis for high-resolution QTL mapping in the Collaborative Cross mouse genetic reference population

(2014) Fuad A. Iraqi et al.   MAMMALIAN GENOME

Digital cell quantification identifies global immune cell dynamics during influenza infection

(2014) Z. Altboum et al.   Molecular Systems Biology

Cellular Changes in Blood Indicate Severe Respiratory Disease during Influenza Infections in Mice

(2014) Leonie Dengler et al.   PLoS One

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

(2014) A. L. Rasmussen et al.   SCIENCE

Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc

(2014) L Patrussi et al.   Cell Death & Disease

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Systems biology and systems genetics—novel innovative approaches to study host–pathogen interactions during influenza infection

(2014) Heike Kollmus et al.   Current Opinion in Virology

Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform Expression

(2014) Hao Xiong et al.   G3-Genes Genomes Genetics

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

(2013) Wei Wang et al.   CELL RESEARCH

Altered Th1/Th2 commitment contributes to lung senescence in CXCR3-deficient mice

(2013) Junmin Huang et al.   EXPERIMENTAL GERONTOLOGY

Using the emerging Collaborative Cross to probe the immune system

(2013) J Phillippi et al.   GENES AND IMMUNITY

Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis

(2013) Israel Vlodavsky et al.   MATRIX BIOLOGY

Versatile role of heparanase in inflammation

(2013) Rachel Goldberg et al.   MATRIX BIOLOGY

Mouse Phenome Database

(2013) Stephen C. Grubb et al.   NUCLEIC ACIDS RESEARCH

QTL mapping in outbred populations: successes and challenges

(2013) Leah C. Solberg Woods   PHYSIOLOGICAL GENOMICS

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross

(2013) Martin T. Ferris et al.   PLoS Pathogens

Role of CXCL5 in Leukocyte Recruitment to the Lungs during Secondhand Smoke Exposure

(2012) Gayathriy Balamayooran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population

(2012)   GENETICS

Mapping of Clinical and Expression Quantitative Trait Loci in a Sex-Dependent Effect of Host Susceptibility to Mouse-Adapted Influenza H3N2/HK/1/68

(2012) G. A. Boivin et al.   JOURNAL OF IMMUNOLOGY

Single and Coexpression of CXCR4 and CXCR5 Identifies CD4 T Helper Cells in Distinct Lymph Node Niches during Influenza Virus Infection

(2012) R. A. Elsner et al.   JOURNAL OF VIROLOGY

Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response

(2012) P. L. Earl et al.   JOURNAL OF VIROLOGY

The molecular basis of leukocyte recruitment and its deficiencies

(2012) Sarah Schmidt et al.   MOLECULAR IMMUNOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Global Transcriptome Analysis in Influenza-Infected Mouse Lungs Reveals the Kinetics of Innate and Adaptive Host Immune Responses

(2012) Claudia Pommerenke et al.   PLoS One

Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets

(2012) Judith M. A. van den Brand et al.   PLoS One

Modification of the Ferret Model for Pneumonia From Seasonal Human Influenza A Virus Infection

(2012) J. M. A. van den Brand et al.   VETERINARY PATHOLOGY

Expression Quantitative Trait Loci for Extreme Host Response to Influenza A in Pre-Collaborative Cross Mice

(2012) Daniel Bottomly et al.   G3-Genes Genomes Genetics

Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross

(2012) Samir N. P. Kelada et al.   G3-Genes Genomes Genetics

Architecture of energy balance traits in emerging lines of the Collaborative Cross

(2011) Wendy Foulds Mathes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic

(2011) Hans D. Klenk et al.   BIOESSAYS

Genetic variants associated with severe pneumonia in A/H1N1 influenza infection

(2011) J. Zuniga et al.   EUROPEAN RESPIRATORY JOURNAL

CCR6 as a mediator of immunity in the lung and gut

(2011) Toshihiro Ito et al.   EXPERIMENTAL CELL RESEARCH

Genetic analysis of complex traits in the emerging Collaborative Cross

(2011) David L. Aylor et al.   GENOME RESEARCH

Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function

(2011) Song Gao et al.   IMMUNITY

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation

(2011) Patrick G. Arndt et al.   PLoS One

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

(2011) Dionne P. Robinson et al.   PLoS Pathogens

2009 pandemic influenza: a review

(2010) Firoza Faruqui et al.   CURRENT OPINION IN PEDIATRICS

Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection

(2010) R. Allard et al.   DIABETES CARE

What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?

(2010) P. HORBY et al.   EPIDEMIOLOGY AND INFECTION

Importance of CXC Chemokine Receptor 2 in Alveolar Neutrophil and Exudate Macrophage Recruitment in Response to Pneumococcal Lung Infection

(2010) W. Herbold et al.   INFECTION AND IMMUNITY

The Novel Activated Microglia/Macrophage WAP Domain Protein, AMWAP, Acts as a Counter-Regulator of Proinflammatory Response

(2010) M. Karlstetter et al.   JOURNAL OF IMMUNOLOGY

Severity of Pneumonia Due to New H1N1 Influenza Virus in Ferrets Is Intermediate between That Due to Seasonal H1N1 Virus and Highly Pathogenic Avian Influenza H5N1 Virus

(2010) Judith M. A. van den Brand et al.   JOURNAL OF INFECTIOUS DISEASES

Inflammatory Caspases in Innate Immunity and Inflammation

(2010) Amir S. Yazdi et al.   Journal of Innate Immunity

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection

(2010) Rudi Alberts et al.   MICROBES AND INFECTION

Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice

(2010) H. Suwanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections

(2009) Barkha Srivastava et al.   PLoS One

The Future of Mouse QTL Mapping to Diagnose Disease in Mice in the Age of Whole-Genome Association Studies

(2008) Kent W. Hunter et al.   Annual Review of Genetics

Relationships between glycosaminoglycan and receptor binding sites in chemokines—the CXCL12 example

(2008) Cédric Laguri et al.   CARBOHYDRATE RESEARCH

Influenza A virus abrogates IFN-γ response in respiratory epithelial cells by disruption of the Jak/Stat pathway

(2008) Kohsaku Uetani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lessons from the past: Familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918

(2008) M. Gottfredsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forward Genetic Dissection of Immunity to Infection in the Mouse

(2007) S.M. Vidal et al.   Annual Review of Immunology

Evidence for a Heritable Predisposition to Death Due to Influenza

(2007) Frederick S. Albright et al.   JOURNAL OF INFECTIOUS DISEASES