Article
Multidisciplinary Sciences
Ni Zhao Wang, Xiang Sheng Yang, Jing Sun, Jin Cun Zhao, Nan Shan Zhong, Xiao Xiao Tang
Summary: This study evaluated the dynamics of lung responses during SARS-CoV-2 infection through transcriptome, proteome, and phosphoproteome analysis of lung tissues from a mouse model. The results showed the fluctuation of host responses and the alternation of signaling pathways and kinases regulating networks at different phases of infection. The study highlighted molecules and signaling pathways that could guide future investigations on COVID-19 therapies.
Article
Immunology
Lei Guo, Nan Li, Zening Yang, Heng Li, Huiwen Zheng, Jinxi Yang, Yanli Chen, Xin Zhao, Junjie Mei, Haijing Shi, G. Scott Worthen, Longding Liu
Summary: The study found that by regulating the expression of the chemokine CXCL5, it can affect the accumulation of neutrophils and B lymphocytes in the lungs during pulmonary influenza infection, thereby altering the immune response to the virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Nian Ma, Juan Lu, Yonggang Pei, Erie S. Robertson
Summary: This study utilized a 3D platform to culture normal oral keratinocyte cells and investigated the molecular interactions between EBV and infected cells. The results identified multiple pathways contributing to distinct pathologies associated with EBV infection and revealed key molecules involved in the regulation of latent and lytic states.
CELL DEATH & DISEASE
(2022)
Article
Microbiology
Xiaohui Ju, Fang Li, Jingrui Li, Chunyan Wu, Guangtao Xiang, Xiaomin Zhao, Yuchen Nan, Dongming Zhao, Qiang Ding
Summary: The study suggests that ASFV infection causes a strong suppression of host immune responses, leading to dysregulation of host chemokine axis and metabolic pathways in porcine alveolar macrophages.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Shinuo Cao, Peng Jia, Zhi Wu, Huipeng Lu, Yuting Cheng, Changchun Chen, Mo Zhou, Shanyuan Zhu
Summary: The African swine fever virus infection stimulates host metabolism pathways while inhibiting immune responses and cell death pathways.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
Qing Yang, Anna E. Elz, Maryline Panis, Ting Liu, Benjamin E. Nilsson-Payant, Daniel Blanco-Melo
Summary: This study investigates the role of influenza A virus NS1 protein in modulating the host immune response, and finds that different levels of NS1 expression have distinct effects on immune antagonism.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Lin Lv, Tianyun Zhang, Hanying Jia, Yanyan Zhang, Asif Ahsan, Xiaoyang Zhao, Teng Chen, Zhiqiang Shen, Ning Shen
Summary: This study investigated the temporal viral and host transcriptomes in porcine alveolar macrophages infected with virulent and attenuated African swine fever virus (ASFV) strains. The findings demonstrated that the attenuated ASFV strain HuB20 can quickly activate the host's antiviral immune response, as well as activating genes associated with RNA virus response in addition to the DNA sensing mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sebastien Boutin, Dagmar Hildebrand, Steeve Boulant, Michael Kreuter, Jule Ruter, Srinivas Reddy Pallerla, Thirumalaisamy P. Velavan, Dennis Nurjadi
Summary: SARS-CoV-2 is the virus causing the major pandemic today, primarily causing lung infection but impacting the body systemically, with fatal outcomes linked to specific host factors and co-morbidities. The virus spreads quickly, affecting individuals of all ages, ethnicities, and gender, with changes in the microbiome believed to play a role in infection acquisition and disease progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Engineering, Environmental
Chao Wang, Wenjiao Wu, Zefen Pang, Jiaxin Liu, Jianxiang Qiu, Tiangang Luan, Jiewei Deng, Zhixin Fang
Summary: Microplastics (MPs) are a type of emerging pollutants that pose a potential threat to human health. This study found that polystyrene microplastics (PS) can promote influenza A virus (IAV) infection. The PS can enrich the virus, enter cells through endocytosis, and downregulate the expression of IFITM3. Furthermore, PS can also down-regulate IRF3 and its active form P-IRF3 by inhibiting TBK1 phosphorylation activation, thereby reducing IFN-beta expression and affecting the cellular innate antiviral immune system.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Immunology
Carola Ledderose, Eleftheria-Angeliki Valsami, Mark Elevado, Wolfgang G. Junger
Summary: The study suggests that ATP release from the lungs of infected mice promotes influenza disease progression by priming peripheral neutrophils, which become strongly activated and cause pulmonary tissue damage after their recruitment to the lungs. This finding highlights ATP-induced neutrophil priming as a potential therapeutic target for reducing lung tissue damage in severe influenza cases.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Virology
Joe McKellar, Antoine Rebendenne, Melanie Wencker, Olivier Moncorge, Caroline Goujon
Summary: Host cells have developed a multi-modular system to detect and combat influenza viruses, including interferon response and intrinsic immunity. These mechanisms activate a wide array of antiviral effectors that inhibit virus replication at various stages, providing important insights for the development of new influenza treatments.
Article
Biotechnology & Applied Microbiology
Britta Lotstedt, Martin Strazar, Ramnik Xavier, Aviv Regev, Sanja Vickovic
Summary: This study presents a novel method called SHM-seq that captures tissue histology, RNA, and bacterial sequences simultaneously from tissues. Using this method, specific gene programs in gut cells related to host-microbe interactions were identified. This approach enhances the understanding of host-microbe interactions in health and disease.
NATURE BIOTECHNOLOGY
(2023)
Article
Veterinary Sciences
Xueyun Li, Jia Liu, Zengzhao Qiu, Qijun Liao, Yani Peng, Yongkun Chen, Yuelong Shu
Summary: The study identified 54 canine-adaptive signatures in H3N2 CIVs and found that IAVs can establish persistent transmission more easily in lower mammals compared to higher mammals. Additionally, 25 common adaptation signatures of H3 IAVs were observed in diverse avian-mammals comparison.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Xiaofeng Dong, Catherine Hartley, John W. Holloway, Jane S. Lucas, Anthony P. Williams, Gabrielle Wheway, Fabio Strazzeri, Aaron Gardner, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Marta E. Polak, Tristan W. Clark, Diana Baralle
Summary: This study compares the immune responses of patients with influenza and COVID-19, identifying differences and identifying genetic markers associated with COVID-19 patient prognosis. An adaptive immune response is associated with COVID-19 survival, while inflammation predicts death. Transcript markers can be used to predict the prognosis of COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Fei Hao, Xing Xie, Maojun Liu, Li Mao, Wenliang Li, Woonsung Na
Summary: Analysis of CpHV-1 infected MDBK cells using RNA-Seq and iTRAQ-LC-MS/MS revealed differentially expressed genes mainly involved in the host innate immune response. The up-regulated DEGs were enriched in pathways related to viral infection, highlighting the importance of host immune response in CpHV-1 pathogenesis.
Article
Immunology
Bastian Hatesuer, Hang Thi Thu Hoang, Peggy Riese, Stephanie Trittel, Ingo Gerhauser, Husni Elbahesh, Robert Geffers, Esther Wilk, Klaus Schughart
JOURNAL OF INNATE IMMUNITY
(2017)
Article
Virology
W. Yang, D. Punyadarsaniya, R. L. O. Lambertz, D. C. C. Lee, C. H. Liang, D. Hoeper, S. R. Leist, A. Hernandez-Caceres, J. Stech, M. Beer, C. Y. Wu, C. H. Wong, K. Schughart, F. Meng, G. Herrler
JOURNAL OF VIROLOGY
(2017)
Article
Microbiology
Wei Yang, Ruth L. O. Lambertz, Darsaniya Punyadarsaniya, Sarah R. Leist, Juergen Stech, Klaus Schughart, Georg Herrler, Nai-Huei Wu, Fandan Meng
VETERINARY MICROBIOLOGY
(2017)
Article
Immunology
Matthias Preusse, Klaus Schughart, Frank Pessler
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Pawel Zmora, Markus Hoffmann, Heike Kollmus, Anna-Sophie Moldenhauer, Olga Danov, Armin Braun, Michael Winkler, Klaus Schughart, Stefan Poehlmann
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Neurosciences
Shirin Hosseini, Esther Wilk, Kristin Michaelsen-Preusse, Ingo Gerhauser, Wolfgang Baumgaertner, Robert Geffers, Klaus Schughart, Martin Korte
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Heike Kollmus, Carolin Pilzner, Sarah R. Leist, Mark Heise, Robert Geffers, Klaus Schughart
Article
Biotechnology & Applied Microbiology
Ruth L. O. Lambertz, Ingo Gerhauser, Inga Nehimeier, Sarah R. Leist, Heike Kollmus, Stefan Poehlmann, Klaus Schughart
JOURNAL OF GENERAL VIROLOGY
(2019)
Article
Virology
Ruth Lydia Olga Lambertz, Ingo Gerhauser, Inga Nehlmeier, Sabine Gaertner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Poehlmann, Klaus Schughart
Correction
Multidisciplinary Sciences
Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Alexander Pausder, Jennifer Fricke, Klaus Schughart, Jens Schreiber, Till Strowig, Dunja Bruder, Julia D. Boehme
Summary: Respiratory Pigr expression and IgA levels are influenced by exposure to microbial stimuli, with differential effects of LPS and IFN-gamma on URT and LRT. Prophylactic IFN-gamma treatment can reduce nasal colonization with S. pneumoniae.
Article
Microbiology
Patrick Waindok, Elisabeth Janecek-Erfurth, Dimitri L. Lindenwald, Esther Wilk, Klaus Schughart, Robert Geffers, Christina Strube
Summary: This study investigated the gene expression changes in the brains of mice infected with Toxocara and identified dysregulated pathways associated with cholesterol biosynthesis, apoptosis signaling, and immune response. The findings provide insights into the pathogenesis of neurotoxocarosis and suggest a potential link between Toxocara infection and dementia or Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Ya Wang, Klaus Schughart, Tiana Maria Pelaia, Tracy Chew, Karan Kim, Thomas Karvunidis, Ben Knippenberg, Sally Teoh, Amy L. Phu, Kirsty R. Short, Jonathan Iredell, Irani Thevarajan, Jennifer Audsley, Stephen Macdonald, Jonathon Burcham, Benjamin Tang, Anthony McLean, Maryam Shojaei
Summary: Compared to healthy individuals and patients with mild/moderate COVID-19, severe COVID-19 patients showed upregulation of growth factor and cell cycle signaling pathways, with downregulation of interferon signaling pathways. Matrix metallopeptidase 9 (MMP9) was found in five of the top 10 upregulated pathways, indicating its potential as a therapeutic target against COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Laura Heydemann, Malgorzata Ciurkiewicz, Georg Beythien, Kathrin Becker, Klaus Schughart, Stephanie Stanelle-Bertram, Berfin Schaumburg, Nancy Mounogou-Kouassi, Sebastian Beck, Martin Zickler, Mark Kuehnel, Guelsah Gabriel, Andreas Beineke, Wolfgang Baumgaertner, Federico Armando
Summary: This study investigates the morphology, phenotype, and transcriptomic features of alveolar regeneration in SARS-CoV-2 infected Syrian golden hamsters. The results demonstrate that the hamster model reliably phenocopies indicators of a dysregulated alveolar regeneration of COVID-19 patients. This provides important information for future research on the pathomechanisms of PASC and for testing prophylactic and therapeutic approaches.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Velma Herwanto, Benjamin Tang, Ya Wang, Maryam Shojaei, Marek Nalos, Amith Shetty, Kevin Lai, Anthony S. McLean, Klaus Schughart
Summary: The data consists of transcriptome data obtained by RNA sequencing from patients with uncomplicated infections, sepsis, septic shock, and healthy controls. This data allows detailed analyses of gene expression changes, identification of differentially expressed genes, co-regulated modules, and pathway activation studies.
BMC RESEARCH NOTES
(2021)