Review
Polymer Science
Avneesh Kumar, Dong Wook Chang
Summary: With the discovery of black phosphorus or phosphorene, scientists are now exploring its unique properties, such as high carrier mobility, biocompatibility, and thickness-dependent band gap, for various applications in nanofillers, energy storage devices, field effect transistors, water disinfection, and biomedical sciences. However, its stability and processability pose challenges, which can be overcome by conjugating it with suitable organic macromolecules, such as polymers, to create composites with enhanced properties and potential applications. These polymer-phosphorene assemblies have the potential to offer multiple applications and shift the focus from graphene to new commercialized products.
Review
Chemistry, Multidisciplinary
Viktoriya Sokolova, Matthias Epple
Summary: Calcium phosphate nanoparticles, due to their similarity to human hard tissue, have high biocompatibility and biodegradability, making them efficient carriers for various biomolecules. They can be functionalized with fluorescing dyes for imaging, and find applications in transfection, gene silencing, imaging, immunization, and bone substitution.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Polymer Science
Magdalena J. Bigaj-Jozefowska, Bartosz F. Grzeskowiak
Summary: Nanotechnology is a widely researched approach to improve cancer therapies, with polymeric nanocarriers playing a crucial role in delivering drugs and enhancing treatment outcomes. Biological membranes, such as those derived from red blood cells or cancer cells, have been extensively studied for their potential in improving biosafety and targeting properties. This review summarizes the development of biomimetic polymeric nanocarriers for efficient cancer treatment.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Yan Zhao, Xiaolu Li, Wenbo Zhang, Lanlan Yu, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji, Luo Zhang, Chenxuan Wang
Summary: EVs play important roles in biomedical applications, acting as efficient drug-delivery carriers and participating in disease diagnosis and treatment. Investigating the origins and working mechanisms of EVs can provide insights into life activities and disease development.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Polymer Science
Elena Ruxandra Radu, Stefan Ioan Voicu, Vijay Kumar Thakur
Summary: Polymeric membranes are selective materials used in a wide range of applications that require separation processes. Due to their remarkable properties, they are also used in biomedical applications to replace the function of organs associated with physiological separations. This review examines various biomedical applications of polymer membranes, including hemodialysis, artificial lung, artificial liver, artificial pancreas, and drug delivery systems.
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Pongpat Sukhavattanakul, Penwisa Pisitsak, Sarute Ummartyotin, Ravin Narain
Summary: This review article provides an overview of the applications of polysaccharides in the field of medical technology. Various types of polysaccharides are presented, including cellulose, chitin and chitosan, hyaluronic acid, alginate, and pectin. The successful development and improvement of polysaccharide-based materials can effectively enhance personal health, reduce costs, and improve the quality of life in a sustainable manner.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Y. T. Kamal
Summary: Polymeric micelles (PMs) have shown significant progress in drug delivery applications due to their robust core-shell structure and ability to solubilize hydrophobic drugs. This review presents the recent advances and understandings of PMs, including preparation methods, applications, and tumor-targeted delivery.
Review
Chemistry, Multidisciplinary
Shixian Lv, Meilyn Sylvestre, Alexander N. Prossnitz, Lucy F. Yang, Suzie H. Pun
Summary: Peptides as promising cancer therapeutics have shown robust antitumor efficacy, but the translation into clinical therapies is hindered by inherent limitations in their structure, hindering intracellular delivery. Strategies to engineer polymeric materials for increased peptide delivery efficiency, especially cytosolic delivery, play a crucial role in potentiating peptide-based cancer therapies. Future opportunities for peptides in cancer treatment lie in the design of polymer nanocarriers for optimized peptide delivery.
Review
Pharmacology & Pharmacy
Xiangjie Di, Xiao Liang, Chao Shen, Yuwen Pei, Bin Wu, Zhiyao He
Summary: This review surveys carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy. Polymeric carbohydrates have advantages of nontoxicity, biocompatibility, and biodegradability, making them an ideal choice for drug targeting, sustained drug release, immune antigens, and adjuvants.
Review
Materials Science, Multidisciplinary
Nahit Aktas, Duygu Alpaslan, Tuba Ersen Dudu
Summary: In the past two decades, significant advancements have been made in the development of medical devices and materials, such as stents, biomimetic organs, scaffolds, and vessels. The biocompatibility and side effects of these materials when used in the body have been extensively studied. Various natural and synthetic materials, including hydrogels, have been successfully used in medical and pharmaceutical applications. Organo-hydrogels, a branch of hydrogels, have gained considerable attention due to their unique properties and have been applied in clinical therapy and microscale apertures as sensing components. These materials hold great potential in healthcare applications.
FRONTIERS IN MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Nabira Fatima, Umair Yaqub Qazi, Asim Mansha, Ijaz Ahmad Bhatti, Rahat Javaid, Qamar Abbas, Nimra Nadeem, Zulfiqar Ahmad Rehan, Saima Noreen, Muhammad Zahid
Summary: Graphene-based polymeric composites exhibit excellent antimicrobial properties through physical and chemical damages, with applications in wound bandages, antimicrobial coatings, drug delivery, food packaging, hydrogel formation, and water disinfection. This review provides valuable insights and may stimulate further developments in the promising field of graphene-based materials.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Engineering, Biomedical
Adrija Sinha, Faizan Zarreen Simnani, Dibyangshee Singh, Aditya Nandi, Anmol Choudhury, Paritosh Patel, Ealisha Jha, Raghuraj Singh Chouhan, Nagendra Kumar Kaushik, Yogendra Kumar Mishra, Pritam Kumar Panda, Mrutyunjay Suar, Suresh K. Verma
Summary: Nanotechnology has emerged as a revolutionary technology with a wide range of applications in various industries. Nanobiomaterials, derived from biological elements, have shown great potential in the biomedical field due to their biocompatibility and unique properties. The commercialization of nanotechnology has led to the development of nano-scaffolds, implants, and biosensors, revolutionizing the biomedical field. This review explores the diverse emerging applications of nanobiomaterials and their mechanistic advancements.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Hannah Frizzell, Tiffany J. Ohlsen, Kim A. Woodrow
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
D. C. Forbes, M. Creixell, H. Frizzell, N. A. Peppas
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2013)
Article
Biochemistry & Molecular Biology
Sharon Golan-Paz, Hannah Frizzell, Kim A. Woodrow
MACROMOLECULAR BIOSCIENCE
(2019)
Article
Immunology
H. Frizzell, R. Fonseca, S. N. Christo, M. Evrard, S. Cruz-Gomez, N. G. Zanluqui, B. von Scheidt, D. Freestone, S. L. Park, H. E. G. McWilliam, J. A. Villadangos, F. R. Carbone, L. K. Mackay
SCIENCE IMMUNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jaehyung Park, Hannah Frizzell, Hangyu Zhang, Shijie Cao, Sean M. Hughes, Florian Hladik, David M. Koelle, Kim A. Woodrow
Summary: The study found that chitosan facilitates the transmigration of DCs across the vaginal epithelium in the mouse female reproductive tract. Additionally, ex vivo programming of DCs was shown to enhance the migration of intravaginally administered DCs to draining lymph nodes and stimulate the proliferation of T cells, showing potential to improve the efficacy of DC-based vaccines in the female genital mucosa.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Hannah Frizzell, Jaehyung Park, Natacha Comandante Lou, Kim A. Woodrow
CELLULAR IMMUNOLOGY
(2017)