Article
Chemistry, Applied
Ke Xue, Pan Zhang, Yongfei Zhao, Saidong Sun, Yuanhang Li, Jiankang Liang, Zhengjian Qi
Summary: Photodynamic therapy (PDT) combined with critical organelle targeting using MoTQu and MeTQu probes can effectively ablate malignant tumors. These probes have bright near-infrared fluorescence emission, large stokes shift, and enhanced intramolecular charge transfer. MoTQu, the optimal photosensitizer, exhibits superior anti-photobleaching, biocompatibility, and high-level reactive oxygen species (ROS) generation efficiency. It can target mitochondria and lysosomes in living cells and induce irreversible apoptosis, making it a powerful tool for image-guided PDT.
Article
Engineering, Biomedical
Shaozhen Wang, Yunhui Liao, Zhaoji Wu, Yihong Peng, Yuchen Liu, Yinghua Chen, Longquan Shao, Zhijie Zeng, Yanshan Liu
Summary: The development of lysosomes and mitochondria dual-targeting photosensitizer with near-infrared emission, efficient reactive oxygen generation, good phototoxicity and biocompatibility is highly desired for imaging-guided photodynamic therapy (PDT) for cancer. In this study, a new amphiphilic organic compound (ADB) based on a D-A-& pi;-A structure is designed and investigated. ADB exhibits lysosomes and mitochondria dual-organelles targeting, bright NIR aggregation-induced emission, high singlet oxygen quantum yield, as well as good biocompatibility and stability. ADB can also serve as a two-photon imaging agent for living cells and tissue blood vessel networks. Upon light irradiation, ADB induces mitochondrial membrane potential decrease, abnormal mitochondria morphology, phagocytotic vesicles and lysosomal disruption, leading to cell apoptosis and enhanced antitumor activity. In vivo experiments demonstrate efficient tumor growth inhibition by ADB upon light exposure. These findings highlight the great potential of this dual-organelles targeted ADB in clinical imaging-guided photodynamic therapy, providing a new avenue for developing multi-organelles targeted photosensitizers for efficient cancer treatment.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Gang Yuan, Cheng Lv, Jichao Liang, Xinxin Zhong, Yuan Li, Jiacun He, Anjing Zhao, Li Li, Yuanhe Shao, Xiuhua Zhang, Shengfu Wang, Yu Cheng, Hanping He
Summary: Aggregation-induced emission PSs (AIE-PSs) with enhanced fluorescence intensity and high efficiency of reactive oxygen species (ROS) generation in the aggregation state provide a new strategy for improving fluorescence-imaging-guided photodynamic therapy (PDT). The optimal AIE-PS (TPA-DT-Qy) exhibits highly efficient photodynamic ablation of breast cancer cells and excellent photodynamic inactivation of bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Qing-Song Gu, Ting Li, Wen-Xin Wang, Zhi-Qing Wang, Qiao-Rong Liu, Guo-Jiang Mao, Yongfei Li, Chun-Yan Li
Summary: This study presents the design and synthesis of a novel tumor-targeting fluorescent probe, Cy-Bio-O, which exhibits a good response to pH changes and activates photodynamic and photothermal properties under acidic conditions. The probe demonstrates excellent killing ability of cancer cells and imaging capacity in both cell experiments and animal experiments. With the tumor-targeting ability, Cy-Bio-O achieves the ablation of solid tumors in tumor-bearing mice. This study represents the first exploration and design of a tumor-targeted fluorescent probe for tumor imaging and NIR PDT/PTT dual-modal synergistic therapy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Chao Zhao, Wanlu Sun, Baojin Tan, Dan Su, Yi Liu
Summary: This study designs and synthesizes an activatable near-infrared photosensitizer that can produce singlet oxygen under near-infrared light excitation. It demonstrates excellent antibacterial effect and accelerates the healing of bacterial infection wounds.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Biomedical
Zhenyan He, Yuting Gao, Huimin Zhang, Ying Xue, Fanling Meng, Liang Luo
Summary: A donor-pi-acceptor photosensitizer with near infrared aggregation-induced emission (AIE) is designed and synthesized for imaging-guided two-photon photodynamic therapy (2P-PDT), demonstrating precise cancer treatment through two-photon excitation in the NIR-II window.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Physical
Wen-Bo Zhao, Rui-Ting Wang, Kai-Kai Liu, Meng-Ru Du, Yong Wang, Yu-Qi Wang, Rui Zhou, Ya-Chuan Liang, Ruo-Nan Ma, Lai-Zhi Sui, Qing Lou, Lin Hou, Chong-Xin Shan
Summary: The article introduces a carbon nanodot derived from perilla that can accurately identify and kill specific bacteria, with near-infrared absorption and emission properties; its hydrophobic chain surface enables selective staining of Gram-positive bacteria. In in vivo experiments, it has shown good antibacterial properties and can effectively eliminate inflammation caused by bacterial infections.
Article
Multidisciplinary Sciences
Ming-Yu Wu, Alex Y. H. Wong, Jong-Kai Leung, Chuen Kam, Kenneth Lap-Kei Wu, Ying-Shing Chan, Kai Liu, Nancy Y. Ip, Sijie Chen
Summary: This study developed a high-performance myelin imaging probe PM-ML, which specifically labels myelinated fibers and is compatible with different tissue-clearing methods. The probe demonstrated potential in multiple sclerosis research, providing an important tool for the study of myelin-related diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Hangqi Luo, Shuai Gao
Summary: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is widely used for cancer treatment, but conventional PTT/PDT lack disease recognition ability, resulting in limited therapeutic effects. Integrating fluorescence imaging with PTT/PDT can reveal tumor locations in real-time, enabling early diagnosis and precision treatment. The use of NIR-II fluorescence imaging with PTT/PDT can significantly improve tumor theranostics accuracy and minimize damage to normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Shangli Ding, Mingyan Yang, Jiajia Lv, Hongyu Li, Gang Wei, Jie Gao, Zeli Yuan
Summary: The new multifunctional cyanine-based photosensitizer CLN demonstrates selective targeting of organelles and generation of fluorescence under hypoxic conditions. It can effectively generate reactive oxygen species and kill tumor cells through its response to nitroreductase. The findings suggest the potential for targeted photodynamic therapy using CLN.
Article
Engineering, Environmental
Zixuan Li, Qing Pei, Yonghui Zheng, Zhigang Xie, Min Zheng
Summary: This study successfully synthesized fluorescent carbon dots (CDs) with excellent biosafety, stability, dispersibility, and photodynamic activity. The CDs emitted long-lasting near-infrared (NIR) fluorescence, enabling high penetration and long-term in vivo luminescent imaging of deep tissues. Moreover, the CDs generated abundant reactive oxygen species, effectively inhibiting tumor growth. This work demonstrates the enormous potential of CDs as multifunctional nanoplatforms for biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ming-Yu Wu, Jong-Kai Leung, Chuen Kam, Tsu Yu Chou, Jia-Li Wang, Xueqian Zhao, Shun Feng, Sijie Chen
Summary: This study developed a near-infrared fluorescent probe named TBTCP for real-time imaging of phagocytosis. TBTCP could selectively label the cell plasma membrane and report the cell membrane statuses and macrophage phagocytosis through fluorescence lifetime changes. It provides a functional tool to study phagocytic function-related diseases.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Analytical
Dong-Hui Wang, Li-Jian Chen, Xu Zhao, Xiu-Ping Yan
Summary: This study presents a novel molecular design strategy to enhance the near-infrared aggregation-induced emission (AIE) of photosensitizers while maintaining strong singlet oxygen (O-1(2)) production capacity. The newly designed materials show stronger ability to generate O-1(2) in the aggregate state compared to commercial photosensitizers, and exhibit brighter near-infrared luminescence in the aggregate state. The encapsulated nanoparticles also demonstrate good biocompatibility and efficient photosensitive activity for killing cancer cells.
Article
Chemistry, Multidisciplinary
Liping Qiao, Jiangping Liu, Yunhong Han, Fangmian Wei, Xinxing Liao, Cheng Zhang, Lina Xie, Liangnian Ji, Hui Chao
Summary: The Ru(ii)-BODIPY conjugate, designed rationally, shows intense absorption in the NIR region for enhanced lysosome-targeted PDT in vitro and in vivo, effectively combating malignant melanoma cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Haining Zhang, Chaojun He, Limin Shen, Wenjun Tao, Jianhui Zhu, Jinzhao Song, Ziyong Li, Jun Yin
Summary: An amphiphilic AIE photosensitizer that can easily penetrate bacterial membranes has been developed. Preliminary binding experiments with phospholipids have shown its membrane specificity. The photosensitizer has demonstrated broad-spectrum bacterial staining and photodynamic antibacterial activity against S. aureus and E. coli.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Xianghan Zhang, Sumei Zhao, Zhiqing Gao, Jialin Zhou, Yuqiong Xia, Jie Tian, Changhong Shi, Zhongliang Wang
Summary: Cancer phototheranostics using mitochondria-targeted NIR cyanines encapsulated in liposomal bilayers showed promising results in balancing hydrophilicity and hydrophobicity, as well as improving tumor cell uptake through a bioorthogonal-mediated targeting strategy. The CyBI7-LPB probe exhibited excellent tumor targeting and anti-tumor therapy outcomes in experimental settings.
Article
Chemistry, Multidisciplinary
Chaoqiang Qiao, Xiaofei Wang, Guohuan Liu, Zuo Yang, Qian Jia, Lexuan Wang, Ruili Zhang, Yuqiong Xia, Zhongliang Wang, Yang Yang
Summary: A biomimetic metal-organic framework nanodrug, camouflaged with erythrocyte membrane, demonstrates efficient accumulation and penetration in tumor tissues, while releasing drugs to deplete collagen and increase oxygen supply for enhanced chemotherapy outcomes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hongzhang Deng, Zuo Yang, Xiaoyu Pang, Caiyan Zhao, Jie Tian, Zhongliang Wang, Xiaoyuan Chen
Summary: This study prepared a series of nanoparticles with tunable acid dissociation constant, successfully enhancing the efficacy of CDT in cancer treatment by converting H2O2 into highly toxic hydroxyl radical to kill tumor cells and avoiding clearance by cytoplasmic antioxidants.
Article
Chemistry, Multidisciplinary
Jie Yu, Hua Xiao, Zuo Yang, Chaoqiang Qiao, Bin Zhou, Qian Jia, Zhongdi Wang, Xiaofei Wang, Ruili Zhang, Yang Yang, Zhongliang Wang, Jianxiong Li
Summary: The excessive production of glutathione (GSH) by tumor cells hinders the efficacy of photodynamic therapy and chemotherapy. A novel GSH-inhibiting nanosystem (PCNPs) is reported here for persistent synergistic cancer therapy, offering sustained suppression of GSH biosynthesis and improved drug utilization. The PCNPs also act as efficient singlet oxygen radical generators, enhancing photodynamic therapy.
Article
Multidisciplinary Sciences
Qian Jia, Ruili Zhang, Yongdong Wang, Haohao Yan, Zheng Li, Yanbin Feng, Yu Ji, Zuo Yang, Yang Yang, Kanyi Pu, Zhongliang Wang
Summary: Dysregulated energy metabolism is recognized as a characteristic of cancer. A newly developed fluorescent probe, MACaP9, shows specific response to the acidic tumor environment and converts pH variations into a fluorescence signal, enabling visualization and distinction of tumor from normal tissues.
Article
Multidisciplinary Sciences
Shaohua Qu, Qian Jia, Zheng Li, Zhongliang Wang, Li Shang
Summary: This study synthesized chiral NIR-II fluorescent nanoprobes and investigated the relationship between their chirality and biological functions. The results showed that chirality determined the interaction with serum proteins, cellular uptake efficiency, as well as the localization and elimination in vivo. Engineering the surface chirality of nanoprobes can enhance their targeting capabilities.
Article
Chemistry, Multidisciplinary
Jie Yu, Ruili Zhang, Baihang Chen, Xuelan Liu, Qian Jia, Xiaofei Wang, Zuo Yang, Pengbo Ning, Zhongliang Wang, Yang Yang
Summary: This study establishes a system consisting of a degradable hydrogel dressing that reacts to reactive oxygen species, an encapsulated biosafe nitric oxide donor, and a low concentration of hydrogen peroxide as a disinfectant. This system promotes sustainable wound healing and disinfection by generating nitric oxide and mediating cell migration and collagen synthesis. It also demonstrates synergistic antibacterial properties against antibiotic-resistant bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hailing Zhao, Nan Li, Caixia Ma, Zhengwei Wei, Qiya Zeng, Keyi Zhang, Na Zhao, Ben Zhong Tang
Summary: Two red-emissive luminogens, TPTH and TPTB, with typical aggregation-induced emission characteristics, were developed. TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways by introducing the heavy atom of Br at the end of the alkyl chain. TPTB also showed excellent biocompatibility and proper lipophilicity, making it suitable for long-term cell membrane staining and targeted photodynamic therapy against cancer cells.
CHINESE CHEMICAL LETTERS
(2023)
Article
Multidisciplinary Sciences
Xianghan Zhang, Jingkai Gao, Yingdi Tang, Jie Yu, Si Si Liew, Chaoqiang Qiao, Yutian Cao, Guohuan Liu, Hongyu Fan, Yuqiong Xia, Jie Tian, Kanyi Pu, Zhongliang Wang
Summary: This article presents a method for expanding the repertoire of responsive dyes in biorthogonal chemistry by developing a near-infrared fluorophore that turns on its fluorescence upon biorthogonal reaction. The study discovers a design mechanism for the construction of bioorthogonally activatable NIR fluorophores and demonstrates their potential in sensitive in vivo imaging of tumors.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Jiabao Zhuang, Yiyi Yu, Rouan Su, Qijia Ma, Nan Li, Na Zhao
Summary: In this work, a pH-sensitive ratiometric fluorescent probe (LD-L) was developed to simultaneously stain lipid droplets and lysosomes and monitor the lipophagy process. LD-L showed a significant ratiometric fluorescent response towards pH change, allowing real-time quantification of the pH change of lipid droplets during lipophagy. LD-L could image the intracellular pH with different emission under single excitation wavelength and provided valuable insights into the process of lipophagy.
Article
Chemistry, Multidisciplinary
Jiabao Zhuang, Bing Wang, Huan Chen, Keyi Zhang, Na Zhao, Nan Li, Ben Zhong Tang
Summary: This article describes an organic near-infrared II photosensitizer (TPEQM-DMA) with potential to overcome the hypoxia obstacle in photodynamic therapy. TPEQM-DMA can produce superoxide anion and hydroxyl radical through a low-O2-dependent type-I photochemical process, leading to disruption of cellular redox homeostasis, mitochondrial dysfunction, and increased peroxidized lipids, inducing cellular apoptosis and ferroptosis. TPEQM-DMA nanoparticles were prepared to improve its pharmacological properties and showed promising NIR-II fluorescence imaging-guided photodynamic therapy effect in vivo for tumors.
Article
Chemistry, Multidisciplinary
Qian Jia, Ruili Zhang, Haohao Yan, Yanbin Feng, Fang Sun, Zuo Yang, Chaoqiang Qiao, Xiaocheng Mou, Jie Tian, Zhongliang Wang
Summary: Accurate detection of lung metastasis is crucial for cancer treatment and prognosis, but remains challenging in clinical practice. This study presents a strategy to develop a pH-activatable near-infrared fluorescent nanoprobe for precise identification of lung cancer and pulmonary metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Zhiguo Fang, Chenlei Wang, Jingrun Yang, Zhizheng Song, Chunyu Xie, Yu Ji, Zhongliang Wang, Xiaohui Du, Qiang Zheng, Chunying Chen, Zhiyuan Hu, Yeteng Zhong
Summary: A non-invasive in vivo sO2 imaging technique based on photoluminescence bioimaging in the NIR-IIb window allows for the visualization of sO2 levels in healthy and tumor tissue. Real-time dynamic sO2 imaging reveals cerebral arteries and veins and is consistent with haemodynamic analysis. Tumor-associated vessel sO2 levels can be evaluated using this technique.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiabao Zhuang, Zhedong Ma, Nan Li, Huan Chen, Lijin Yang, Ying Lu, Keyi Guo, Na Zhao, Ben Zhong Tang
Summary: In this study, a dual-targeted photosensitizer DPITQ is developed through molecular engineering, which can induce both pyroptosis and apoptosis for tumor therapy. DPITQ shows high photothermal conversion efficiency and reactive oxygen species generation, with excellent biocompatibility and specific targeting ability. Both in vitro and in vivo experiments demonstrate the therapeutic effect of DPITQ.
ADVANCED MATERIALS
(2023)
Review
Medicine, Research & Experimental
Zhiping Rao, Yutong Zhu, Peng Yang, Zhuang Chen, Yuqiong Xia, Chaoqiang Qiao, Weijing Liu, Hongzhang Deng, Jianxiong Li, Pengbo Ning, Zhongliang Wang
Summary: Pyroptosis is a critical type of programmed cell death that plays a key role in host defense against pathogen infection and can serve as a new strategy for cancer elimination. Excessive pyroptosis, however, may lead to inflammatory diseases. Therefore, it is important to fully understand the molecular mechanisms and therapeutic implications of pyroptosis.
