Article
Biotechnology & Applied Microbiology
Qianru Li, Qianqian Liu, Heli Li, Liyun Dong, Yajie Zhou, Jintao Zhu, Liu Yang, Juan Tao
Summary: Nanomedicine has shown great potential in cancer immunotherapy, but there are still limitations in nanoparticle-based immunotherapy. In this study, researchers discovered that encapsulating a photosensitizer in nanoparticles can achieve synergy between photodynamic therapy and immunotherapy. Through experiments, they demonstrated the significant effectiveness of this nanotherapeutic system in inducing antitumor immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Acoustics
Maryam Zolghadrnasab, Amir Mousavi, Abbas Farmany, Ayyoob Arpanaei
Summary: This study synthesized PEI-coated MSNs for efficient delivery of GUS-encoding plasmid DNA into tobacco cells using ultrasound treatment. It was found that high levels of sonoporation may affect cell viability adversely. Optimal conditions for ultrasonic treatment were determined as 8 minutes at 160, 320, and 640 W, showing the potential for an economical and straightforward approach for gene transfer in plant cells.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuqi Chen, Xuelian Wang, Zhuhang Lu, Cong Chang, Yueli Zhang, Yuyang Li, Mengqi Yi, Bei Xiong, Bo Lu
Summary: This study developed a pH/NIR dual-responsive HMSNs-based nanocarrier for co-delivering DOX and ICG, which are used for chemotherapy and phototherapy respectively. The results demonstrated that the nanocarrier could target HepG2 cells and reduce the activity of tumor cells, providing a feasible strategy for targeted combined chemotherapy and phototherapy for tumors.
PROCESS BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Haesoo Lee, Miseop Choi, Ha-Eun Kim, Minki Jin, Woo-Jin Jeon, Minwoo Jung, Hyelim Yoo, Jong-Hee Won, Young-Guk Na, Jae-Young Lee, Hasoo Seong, Hong-Ki Lee, Cheong-Weon Cho
Summary: In this study, doxorubicin-loaded mesopomus silica nanoparticles (MSNs) coated with mannose grafted poly (acrylic acid) copolymer (DOX@MSNs-man-g-PAA) were developed to enhance the hemocompatibility and target efficacy to cancer cells. The DOX@MSNs-man-g-PAA showed sustained and pH-dependent drug release with improved hemocompatibility and enhanced uptake in breast cancer cells through mannose receptor-mediated endocytosis, leading to increased intracellular ROS and changes in mitochondrial membrane potential. This formulation exhibited superior tumor-suppressing activity in mice inoculated with MDA-MB-231 cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Cheng Xu, Hannah E. Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W. Tai, Yu Leo Lei, James J. Moon
Summary: This study developed a manganese-silica nanoplatform (MnOx@HMSN) that enhances the adjuvant effects of CDNs for vaccination against cancer and SARS-CoV-2. The nanoplatform efficiently co-loaded CDNs and antigens, resulting in robust immune responses and therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biophysics
Dajun Xu, Xiaoxiao Song, Jiahong Zhou, Xueliang Ouyang, Jinping Li, Dawei Deng
Summary: Virus-like hollow mesoporous silica nanoparticles with unique surface structure were prepared, enhancing cellular uptake and amplifying immune response. By loading doxorubicin, a combination of chemotherapy and immunotherapy was achieved. This study provides a promising platform for drug delivery with superior cellular uptake property.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Soroush Mirfakhraee, Reza Bafkary, Yalda H. Ardakani, Rassoul Dinarvand
Summary: In this study, hyaluronic acid-functionalized disulfide hollow mesoporous silica nanoparticles (HMSN-NH2-HA) were synthesized and characterized as an anticancer drug delivery system. The nanoparticles demonstrated controlled release and targeted delivery of DOX, showing potential application in cancer treatment.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yimin Zhou, Cong Chang, Zuhao Liu, Qiuling Zhao, Qingni Xu, Chaohua Li, Yuqi Chen, Yueli Zhang, Bo Lu
Summary: The study successfully developed ID@HMSNs-B-HA nanoparticles for targeted drug delivery, showing sustained drug release under acidic conditions with effective inhibition of murine mammary carcinoma (4T1) cells through combined chemotherapy and photodynamic therapy. The results indicated that ID@HMSNs-B-HA could be a promising nano-DDS for cancer treatment.
Article
Pharmacology & Pharmacy
Jason William Grunberger, Hamidreza Ghandehari
Summary: Silica nanoparticles (SNPs) have versatile synthetic methods and tunable physicochemical properties, making them promising for biomedical applications. In this study, hollow mesoporous SNPs (HMSNPs) with different layer compositions were fabricated, and their degradation profiles were characterized in simulated body fluid. The results showed that the composition and number of layers influenced degradation rates, with particles containing more disulfide bridges being more responsive to enzymatic degradation. These findings suggest the potential utility of layer-by-layer HMSNPs for controlled drug delivery.
Article
Pharmacology & Pharmacy
Zahra Mohebian, Mirzaagha Babazadeh, Nosratollah Zarghami, Hanieh Mousazadeh
Summary: In this study, Curcumin was successfully incorporated into mesoporous silica nanoparticles and then embedded into a polymer via a blending electrospinning process to create a nanofiber-mediated drug release system. The resulting composite nanofibers showed sustained drug release properties and demonstrated high cytotoxicity and low migration in treating breast cancer cells, suggesting a promising potential for post-surgical breast cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Shiwei Niu, Xuejing Zhang, Gareth R. Williams, Jianrong Wu, Feng Gao, Zi Fu, Xia Chen, Sheng Lu, Li-Min Zhu
Summary: The study encapsulated the anticancer drug doxorubicin (DOX) in chitosan (CS)-modified hollow mesoporous silica nanoparticles (HMSNs), with CuS nanodots generating energy under near infrared laser (NIR) irradiation to accelerate drug release, achieving targeted drug delivery to the tumor microenvironment while demonstrating excellent photothermal therapy and dual-imaging properties.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Applied
Olivija Plohl, Saso Gyergyek, Lidija Fras Zemljic
Summary: The article discusses the design of environmentally-friendly nanocarriers for improved controlled pesticide release, which also act as a potential soil improver by providing Si and N as key nutrient sources. The study developed a novel delivery system for post-loading a biopesticide onto mesoporous silica nanoparticles (MeSiNPs) functionalised with N-rich polymer, showing efficient controlled and slow release behavior for the model biopesticide citridiol.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Engineering, Biomedical
Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Tadao Ohno
Summary: In this study, a combination therapy of an immune checkpoint inhibitor and an HMS-based cancer vaccine was proposed to enhance the therapeutic efficacy of the immune checkpoint inhibitor. The HMS-based cancer vaccine acts as an adjuvant to activate dendritic cells and present antigens. The results showed that the combination therapy reduced the required dose of the immune checkpoint inhibitor and increased the anti-tumor effect, along with increased CD4+ and CD8+ T cell populations.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Applied
Ruoshi Zhang, Xin Wang, Na Fan, Jing Li
Summary: The Fe(III) loaded porous silica nanoparticles have shown promising potential for establishing an anticancer drug delivery system. Through pH-triggered release and high anti-cancer activity, DOX loaded MM-SN-NH2-Fe demonstrated superior efficacy in both in vitro and in vivo experiments.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Ge Xie, Shuo Du, Qiuyi Huang, Qiao Hu, Duohang Bi, Bolun Peng, Juan Tao, Lianbin Zhang, Jintao Zhu
Summary: This study proposes a composite hydrogel that can generate photothermal components and perform mild-temperature photothermal disinfection on demand by elegantly tuning the binding and release of iodine and starch. The composite hydrogel can respond to bacterial metabolism and produce color changes, allowing for naked-eye observation. Under the combined treatment of heating/I2/Zn2+, the composite hydrogel can completely kill Escherichia coli and Staphylococcus aureus at a mild temperature of around 41 degrees C.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Bolun Peng, Quanqian Lyu, Miaomiao Li, Shuo Du, Jintao Zhu, Lianbin Zhang
Summary: Solar steam generation through hydrogel-based evaporators has shown great promise for freshwater production. However, developing hydrogel-based evaporators with stable performance in high-salinity brines remains challenging. In this study, phase-separated polyzwitterionic hydrogel-based evaporators with sponge-like structures were fabricated and shown to demonstrate stable water evaporation rates and high solar-to-vapor efficiency in high-salinity brines under simulated solar light irradiation. The polyzwitterionic hydrogel evaporators with sponge-like porous structures have potential applications in high-salinity seawater desalination.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaodong Chen, Xiujuan Zhang, Hui Wang, Lianbin Zhang, Jintao Zhu
Summary: We report a novel photonic crystal-based sensor chips for trace detection of explosives. The sensor chips consist of silica nanoparticles modified with (3-aminopropyl)triethoxysilane and fluorescein isothiocyanate isomer, and photonic crystal substrates. The fluorescence signal of the nanoparticles can be strongly quenched by the binding of TNT molecules, and the photonic crystals can amplify the fluorescence signal by about 24.4-fold, greatly improving the sensitivity and resolution of trace TNT detection.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Ruixia Kong, Jingli Ren, Min Mo, Lianbin Zhang, Jintao Zhu
Summary: A multifunctional coating with antifogging, self-cleaning, antibacterial, and self-healing capabilities, based on polyelectrolyte complexes, has been developed. The coating, named PEI-PA-Cu, can be easily applied to various substrates and maintains excellent antifogging performance in high and low temperature environments. Moreover, it exhibits self-cleaning properties and effective antibacterial capability, as well as rapid and repeated self-healing ability. This study provides a promising solution for the development of multifunctional superhydrophilic coatings for personal protective, medical, and optical devices.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Biochemistry & Molecular Biology
Ge Xie, Xiao Wang, Min Mo, Lianbin Zhang, Jintao Zhu
Summary: Photothermal hydrogels, as an important platform for photothermal therapies, have shown promising prospects in the field of infected wound treatments. This review summarizes the progress, challenges, and prospects of photothermal hydrogels in promoting infected wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Hua Wang, Yangxue Fu, Pei Liu, Fei Qu, Shuo Du, Yan Li, Hongyao Du, Lianbin Zhang, Juan Tao, Jintao Zhu
Summary: A mechanically robust supramolecular dissolving microneedle (DMN) patch loaded with triamcinolone acetonide (TA) has been developed for efficient treatment of psoriasis. This innovative approach shows promising applications in transdermal drug delivery and expands the range of drugs in DMNs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Hua Wang, Yangxue Fu, Shuo Du, Pei Liu, Jingli Ren, Yijing Liu, Juan Tao, Lianbin Zhang, Jintao Zhu
Summary: Antimicrobial photodynamic therapy (PDT) is a promising strategy for eradicating biofilms, but its efficacy is hindered by the low solubility and poor penetration of photosensitizers (PSs) into the biofilms. This study develops a dissolving microneedle (DMN) patch composed of a supramolecular PS for enhanced biofilm penetration and eradication. The DMN patch can efficiently penetrate the biofilms, allowing for optimal photodynamic elimination of bacterial biofilms. In addition, the DMN patch shows good biosafety in vivo for eradicating Staphylococcus aureus biofilm infection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Duohang Bi, Fei Qu, Wanyue Xiao, Jiaxin Wu, Pei Liu, Hongyao Du, Youwei Xie, Hongmei Liu, Lianbin Zhang, Juan Tao, Yijing Liu, Jintao Zhu
Summary: This study developed detachable H2O2-responsive gel-based microneedle (MN) patches containing methotrexate (MTX) and epigallocatechin gallate (EGCG), which showed dual-mode drug release kinetics and improved treatment outcomes in psoriasis-like animal models. The gel-based MNs extended skin retention of EGCG, leading to prolonged ROS scavenging effects. These ROS-responsive MN patches delivered antiproliferative and anti-inflammatory drugs transdermally, demonstrating potential for improved psoriasis treatment.
Article
Energy & Fuels
Junsheng Fei, Min Wang, Jinbu Li, Chen Zhao, Xin Wang, Lianbin Zhang, Changqi Yu, Ying Li, Shangde Dong
Summary: Based on molecular dynamics (MD) simulation, the adsorption and absorption of shale oil in a type II kerogen slit were calculated, and the influences of temperature, pressure, and pore diameter on the occurrence of shale oil were discussed. The results showed that temperature had opposite effects on the distribution of shale oil in adsorption and absorption, while pressure and pore diameter had minimal influence. Under aqueous conditions, the absorption of shale oil was blocked once water clusters formed. The evolution of the ratio of free-adsorbed-absorbed oil at different temperatures and pressures was also established, providing a new method for detecting the occurrence and mobility evaluation of shale oil under reservoir conditions.
Article
Chemistry, Physical
Jingli Ren, Ruixia Kong, Huiying Wang, Shuo Du, Pei Liu, Hua Wang, Yu Chen, Ge Xie, Lianbin Zhang, Jintao Zhu
Summary: A novel solvent-exchange-triggered adhesive with robust dry/underwater adhesion performance is presented in this study. It shows great potential in biomedical applications.
Article
Nanoscience & Nanotechnology
Yu Chen, Yi Yang, Shuo Du, Jingli Ren, Hao Jiang, Lianbin Zhang, Jintao Zhu
Summary: In this study, a near-infrared light-regulated PDT nanoplatform (TPP-UCNPs@MOF-Pt) was constructed to overcome the limitations of tumor hypoxia in photodynamic therapy. The nanoplatform effectively relieved tumor hypoxia by converting H2O2 to oxygen and enhanced PDT efficacy under NIR light irradiation. Additionally, the TPP-UCNPs@MOF-Pt targeted mitochondria, causing mitochondrial membrane depolarization and activation of the apoptotic pathway, further amplifying the therapeutic efficacy. In vitro and in vivo experiments demonstrated the significantly enhanced photodynamic therapeutic efficacy of TPP-UCNPs@MOF-Pt. This study provides a promising strategy for the construction of an MOF-based multifunctional nanoplatform to address the limitations of PDT treatment for hypoxic tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hui Wang, Xiaodong Chen, Ge Xie, Duohang Bi, Shuo Du, Miaomiao Li, Lianbin Zhang, Jintao Zhu
Summary: A novel light-harvesting platform is designed by decorating photosensitizer Ce6 into an inverse opal photonic hydrogel framework to enhance the efficiency of photodynamic antibacterial therapy. It is shown that the relative positions of the photonic bandgap of the hydrogel and the absorption band of Ce6 can tune the generation efficiency of singlet oxygen. The slow photons at the blue edge of the photonic bandgap exhibit advantages in improving singlet oxygen generation compared to those at the red edge.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Meiru Zhao, Peng Ren, Quanqian Lyu, Xiaodong Chen, Hui Wang, Miaomiao Li, Lianbin Zhang, Jintao Zhu
Summary: In this study, a mechanochromic and electromechanical PI-skin with superior adhesion, sensitivity, stability, and self-healing ability is presented for visualizing wearable strain distributions and monitoring human motions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Tian Zhang, Xiaolu Jia, Zaiyan Hou, Ge Xie, Lianbin Zhang, Jintao Zhu
Summary: Multiple responsive photonic prints are created by introducing an interpenetrating polymer network (IPN) within photonic hydrogels. These prints can exhibit different colors under thermal or light stimuli due to the regionally different network structure and varied responsiveness. The localized IPN structure, formed by combining a thermo-responsive polymer with carbon-encapsulated Fe3O4 nanoparticles, allows for full-color pattern display and offers potential applications in anti-counterfeiting and information encoding.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2023)
Review
Materials Science, Multidisciplinary
Xiaodong Chen, Zhen Hu, Quanqian Lyu, Miaomiao Li, Lianbin Zhang, Jintao Zhu
Summary: Shape memory photonic materials (SMPMs) are intelligent materials with shape memory abilities and optical stability, showing great potential in various applications.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)