期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 197, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111452
关键词
Virus-like; Mesoporous silica; Perovskite template; Cancer combination therapy
资金
- Jiangsu Provincial Natural Science Fund for Distinguished Young Scholars [BK20190028]
- National Natural Science Foundation of China [81371627, 81727804]
- Double First-Class University project [CPU2018GY24, CPU2018GY20]
Virus-like hollow mesoporous silica nanoparticles with unique surface structure were prepared, enhancing cellular uptake and amplifying immune response. By loading doxorubicin, a combination of chemotherapy and immunotherapy was achieved. This study provides a promising platform for drug delivery with superior cellular uptake property.
Virus-like nanostructures could involve their interaction with biological hosts, as well as adaptive immune responses. Herein, imitating the intrinsic structure of virus, we formulated novel virus-like hollow mesoporous silica nanoparticles (VH-MSNs) by using self-consuming perovskite template. The unique topological structure on the surface of nanoparticles could enhance cellular uptake and amplify the immune response. By loading doxorubicin (DOX) on nanoparticles, we achieved a combination of chemotherapy and immunotherapy. This study provides a promising platform with superior cellular uptake property for drug delivery and a basis for the study of the effect of surface physical structure on the nanocarriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据