Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far

A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita

(2019) Zakia Kanwal et al.   Nanomaterials

Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases Its Immunotoxicity

(2019) Jessica Da Silva et al.   Frontiers in Bioengineering and Biotechnology

In vitro and in vivo toxicity assessment of alginate/eudragit S 100-enclosed chitosan–calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs)

(2018) Khoo Miew Leng et al.   BIOMEDICINE & PHARMACOTHERAPY

Chitosan nanoparticles’ functionality as redox active drugs through cytotoxicity, radical scavenging and cellular behaviour

(2018) Sreelatha Sarangapani et al.   Integrative Biology

Development of a systematic method to assess similarity between nanomaterials for human hazard evaluation purposes – lessons learnt

(2018) Margriet VDZ Park et al.   Nanotoxicology

Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells

(2018) Hao Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Metallic Nanoparticles: General Research Approaches to Immunological Characterization

(2018) Francesca Gatto et al.   Nanomaterials

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

(2017) Maria Dusinska et al.   FOOD AND CHEMICAL TOXICOLOGY

Oleanolic–bioenhancer coloaded chitosan modified nanocarriers attenuate breast cancer cells by multimode mechanism and preserve female fertility

(2017) Monika Sharma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Еvaluation of biocompatibility and antioxidant efficiency of chitosan-alginate nanoparticles loaded with quercetin

(2017) Denitsa Aluani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

(2017) Jing Zhang et al.   International Journal of Nanomedicine

Dual tumor-targeted poly(lactic-co-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

(2017) Jia Chen et al.   International Journal of Nanomedicine

Mucopenetrating nanoparticles for enhancement of oral bioavailability of furosemide: In vitro and in vivo evaluation/sub-acute toxicity study

(2017) Salma El-Sayed Radwan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The effect of particle shape on cellular interaction and drug delivery applications of micro- and nanoparticles

(2017) Anil B. Jindal   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of in vitro antifungal efficacy and in vivo toxicity of Amphotericin B-loaded PLGA and PLGA-PEG blend nanoparticles

(2017) T.C. Moraes Moreira Carraro et al.   JOURNAL DE MYCOLOGIE MEDICALE

Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping

(2017) Robert Landsiedel et al.   JOURNAL OF NANOPARTICLE RESEARCH

Preparation and evaluation of biopolymeric nanoparticles as drug delivery system in effective treatment of rheumatoid arthritis

(2017) Vijay Kumar et al.   PHARMACEUTICAL RESEARCH

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

(2017) Rahim Dad Brohi et al.   Frontiers in Pharmacology

Nanomaterial Drug Products: Manufacturing and Analytical Perspectives

(2016) Christie M. Sayes et al.   AAPS Journal

Polymeric micelles of amphiphilic graft copolymer of α -tocopherol succinate- g -carboxymethyl chitosan for tamoxifen delivery: Synthesis, characterization and in vivo pharmacokinetic study

(2016) Sunil K. Jena et al.   CARBOHYDRATE POLYMERS

Characterization and toxicology evaluation of chitosan nanoparticles on the embryonic development of zebrafish, Danio rerio

(2016) Yanbo Wang et al.   CARBOHYDRATE POLYMERS

Safety assessment of nanoparticles for drug delivery by means of classicin vitroassays and beyond

(2016) Stefan Lorscheidt et al.   Expert Opinion on Drug Delivery

Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery

(2016) Joydeep Das et al.   HUMAN REPRODUCTION UPDATE

Structure and function: Lipid A modifications in commensals and pathogens

(2016) Alex Steimle et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Cytotoxic and cytostatic side effects of chitosan nanoparticles as a non-viral gene carrier

(2016) Gizem Bor et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Surface-Modified Biodegradable Nanoparticles' Impact on Cytotoxicity and Inflammation Response on a Co-Culture of Lung Epithelial Cells and Human-Like Macrophages

(2016) Nadège Grabowski et al.   Journal of Biomedical Nanotechnology

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

(2016) Abhijit A. Date et al.   JOURNAL OF CONTROLLED RELEASE

Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells

(2016) Divya Arora et al.   Materials Science & Engineering C-Materials for Biological Applications

Tamoxifen-loaded poly(L-lactide) nanoparticles: Development, characterization and in vitro evaluation of cytotoxicity

(2016) Clescila Altmeyer et al.   Materials Science & Engineering C-Materials for Biological Applications

Quantifying ROS levels using CM-H 2 DCFDA and HyPer

(2016) Monika Oparka et al.   METHODS

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

(2016) Xiuying Shan et al.   Molecular Medicine Reports

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting

(2016) Brian Palmer et al.   MOLECULES

Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing

(2016) E. Lorge et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Evaluation of polylactic acid nanoparticles safety using Drosophila model

(2016) Sophie Legaz et al.   Nanotoxicology

Framework to Evaluate Exposure Relevance and Data Needs for Risk Assessment of Nanomaterials usingin VitroTesting Strategies

(2016) Monita Sharma et al.   RISK ANALYSIS

Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice

(2016) Yun-Jung Choi et al.   Oncotarget

Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations

(2016) Hamidreza Fasehee et al.   JOURNAL OF NANOBIOTECHNOLOGY

In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy

(2016) Hee Dong Han et al.   Scientific Reports

Nanoparticle interaction with the immune system / Interakcije nanodelcev z imunskim sistemom

(2015) Veno Kononenko et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

(2015) Sara Salatin et al.   CELL BIOLOGY INTERNATIONAL

Impact of poly(lactic- co -glycolic acid) nanoparticle surface charge on protein, cellular and haematological interactions

(2015) Gopikrishna J. Pillai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lineage-related and particle size-dependent cytotoxicity of chitosan nanoparticles on mouse bone marrow-derived hematopoietic stem and progenitor cells

(2015) Siti Sarah Omar Zaki et al.   FOOD AND CHEMICAL TOXICOLOGY

pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery

(2015) Piyasi Mukhopadhyay et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Surface coating mediates the toxicity of polymeric nanoparticles towards human-like macrophages

(2015) Nadège Grabowski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of the surface charge of PLGA nanoparticles on theirin vitrogenotoxicity, cytotoxicity, ROS production and endocytosis

(2015) Anne Platel et al.   JOURNAL OF APPLIED TOXICOLOGY

Biocompatibility Assessment of Polyethylene Glycol-Poly L-Lysine-Poly Lactic-Co-Glycolic Acid Nanoparticles In Vitro and In Vivo

(2015) Liting Guo et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Comparedin vivotoxicity in mice of lung delivered biodegradable and non-biodegradable nanoparticles

(2015) Letícia Aragao-Santiago et al.   Nanotoxicology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Polymeric nanoparticles: the future of nanomedicine

(2015) Brittany L. Banik et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

(2015) Michał Moritz et al.   Advances in Clinical and Experimental Medicine

Toxicity of Nanomaterials

(2015) Haseeb A. Khan et al.   Biomed Research International

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

(2015) Puja Khanna et al.   Nanomaterials

Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats

(2015) Zhong-Yue Yuan et al.   PLoS One

Preparation, blood coagulation and cell compatibility evaluation of chitosan-graft-polylactide copolymers

(2014) Qi Wang et al.   Biomedical Materials

Protein corona change the drug release profile of nanocarriers: The “overlooked” factor at the nanobio interface

(2014) Shahed Behzadi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Non-ionic surfactants as novel intranasal absorption enhancers:in vitroandin vivocharacterization

(2014) Ying Li et al.   DRUG DELIVERY

Is nanotechnology a boon for oral drug delivery?

(2014) Udita Agrawal et al.   DRUG DISCOVERY TODAY

Nanomedicine I: In vitro and in vivo evaluation of paclitaxel loaded poly-(ε-caprolactone), poly (dl-lactide-co-glycolide) and poly (dl-lactic acid) matrix nanoparticles in wistar rats

(2014) Sekar VasanthaKumar et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

In vitro and in vivo safety evaluation of low molecular weight chitosans prepared by hydrolyzing crab shell chitosans with bamboo shoots chitosanase

(2014) Ya-Min Chang et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

(2014) Dongwoo Khang et al.   International Journal of Nanomedicine

Antimutagenic compounds and their possible mechanisms of action

(2014) Karolina Słoczyńska et al.   JOURNAL OF APPLIED GENETICS

Zebrafish as an In Vivo High-Throughput Model for Genotoxicity

(2014) Sridhara Chakravarthy et al.   Zebrafish

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations

(2014) Manzoor Ahmad Gatoo et al.   Biomed Research International

Chitosan Nanoparticles Cause Pre- and Postimplantation Embryo Complications in Mice1

(2013) Mi-Ryung Park et al.   BIOLOGY OF REPRODUCTION

Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

(2013) Jianling Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hematotoxicological analysis of surface-modified and -unmodified chitosan nanoparticles

(2013) Ragima Nadesh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Influence of Nanoparticle Shape, Size, and Surface Functionalization on Cellular Uptake

(2013) Ningning Ma et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classicin vitrotests

(2013) Rina Guadagnini et al.   Nanotoxicology

Immunotoxicity and genotoxicity testing of PLGA-PEO nanoparticles in human blood cell model

(2013) Jana Tulinska et al.   Nanotoxicology

Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells

(2013) Rina Guadagnini et al.   Nanotoxicology

Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

(2013) Zuzana Magdolenova et al.   Nanotoxicology

Accumulated Polymer Degradation Products as Effector Molecules in Cytotoxicity of Polymeric Nanoparticles

(2013) Raman Preet Singh et al.   TOXICOLOGICAL SCIENCES

Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-treated cells

(2013) A. Aranda et al.   TOXICOLOGY IN VITRO

Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells

(2012) Ramona Lieder et al.   Acta Biomaterialia

Interference of engineered nanoparticles with in vitro toxicity assays

(2012) Alexandra Kroll et al.   ARCHIVES OF TOXICOLOGY

Toxico-/biokinetics of nanomaterials

(2012) Robert Landsiedel et al.   ARCHIVES OF TOXICOLOGY

The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells

(2012) Bhanuprasanth Koppolu et al.   BIOMATERIALS

Biocompatibility, cellular uptake and biodistribution of the polymeric amphiphilic nanoparticles as oral drug carriers

(2012) Ya Liu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Galactose decorated PLGA nanoparticles for hepatic delivery of acyclovir

(2012) Swati Gupta et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Improved antifungal activity of itraconazole-loaded PEG/PLA nanoparticles

(2012) Sherief Essa et al.   JOURNAL OF MICROENCAPSULATION

Toxicity of nanomaterials

(2011) Shahriar Sharifi et al.   CHEMICAL SOCIETY REVIEWS

Development of lauroyl sulfated chitosan for enhancing hemocompatibility of chitosan

(2011) R. Shelma et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model

(2011) Jian-Qing Gao et al.   International Journal of Nanomedicine

Nanotoxicology and nanoparticle safety in biomedical designs

(2011) Esmaeil Biazar et al.   International Journal of Nanomedicine

In vitro biomechanical and biocompatible evaluation of natural hydroxyapatite/chitosan composite for bone repair

(2011) Xiaoying Lü et al.   Journal of Applied Biomaterials & Biomechanics

Toxicology and clinical potential of nanoparticles

(2011) Lara Yildirimer et al.   Nano Today

Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects

(2011) Gertie J. Oostingh et al.   Particle and Fibre Toxicology

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity assessment of nanomaterials: methods and challenges

(2010) Alok Dhawan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Evaluation of the Genotoxicity of Chitosan Nanoparticles for Use in Food Packaging Films

(2010) Renata De Lima et al.   JOURNAL OF FOOD SCIENCE

Acute toxicity and genotoxicity studies on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) nanomaterials

(2010) Yina Huang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Ambiguities in applying traditionalLimulusAmebocyte Lysate tests to quantify endotoxin in nanoparticle formulations

(2010) Marina A Dobrovolskaia et al.   Nanomedicine

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Reproductive and developmental toxicity studies of manufactured nanomaterials

(2010) Makoto Ema et al.   REPRODUCTIVE TOXICOLOGY

In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: Cyto-, genotoxicity and oxidative stress

(2010) S. Barillet et al.   TOXICOLOGY LETTERS

In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery

(2009) Kiran Sonaje et al.   BIOMATERIALS

Antioxidant activity of chitooligosaccharides upon two biological systems: Erythrocytes and bacteriophages

(2009) João C. Fernandes et al.   CARBOHYDRATE POLYMERS

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The status ofin vitrotoxicity studies in the risk assessment of nanomaterials

(2009) Margriet VDZ Park et al.   Nanomedicine

Evaluation of nanoparticle immunotoxicity

(2009) Marina A. Dobrovolskaia et al.   Nature Nanotechnology

Antioxidant properties of chitosan from crab shells

(2008) Ming-Tsung Yen et al.   CARBOHYDRATE POLYMERS

Method for Analysis of Nanoparticle Hemolytic Properties in Vitro

(2008) Marina A. Dobrovolskaia et al.   NANO LETTERS