Article
Cell Biology
Wen-Ya Huang, Zhi-Bin Liao, Jia-Cheng Zhang, Xin Zhang, Hong-Wei Zhang, Hui-Fang Liang, Zun-Yi Zhang, Tao Yang, Jia Yu, Ke-Shuai Dong
Summary: The study showed that TXNRD1 is upregulated in HCC tumors and correlates with poor patient survival. Functional studies demonstrated that TXNRD1 promotes HCC cell proliferation and metastasis. USF2 acts as a tumor suppressor by inhibiting TXNRD1 expression in HCC progression.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen
Summary: The study demonstrated that eIF6 expression was significantly increased in HCC and correlated with its pathological progression. eIF6 served as a new diagnostic biomarker and an independent risk factor for OS in HCC patients. Functional studies showed that deletion of eIF6 exhibited tumor-suppressor activity in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Peifang Qin, Jianguo Yan, Haitao Huang, Qi Wang, Mao Li, Yuting Zhang, Jiahui Wang, Tingting Jiang, Xiaoling Zhang, Yali Zhou
Summary: Equilibrative nucleoside transporter 3 (ENT3), a member of the solute carrier family 29, plays an important role in hepatocellular carcinoma (HCC). It is upregulated in HCC and associated with poor prognosis and clinical features. Knockdown of ENT3 inhibits cell proliferation, migration, and invasion, and promotes apoptosis through inhibition of the AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Yanqing Ye, Maosheng Liu, Fengfei Wu, Shiyu Ou, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
Summary: TRMT6 is overexpressed in HCC tissues and associated with TNM stage, T classification, and N classification. Overexpression of TRMT6 promotes HCC cell proliferation through the PI3K/AKT/mTOR axis in vivo and in vitro. Inhibition of TRMT6 reduces tumor growth and is related to the PI3K/AKT pathway.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ling-Yu Tian, Daniel J. Smit, Manfred Juecker
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC, and understanding its role in regulating cellular metabolism is crucial for developing novel therapies for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Mohammed Bourouh, Paola A. Marignani
Summary: Liver kinase B1 (LKB1) is a crucial tumor suppressor kinase that plays a role in various malignancies. It inhibits the growth and division of cancer cells by regulating metabolic pathways. Loss of LKB1 leads to metabolic reprogramming and promotes malignant growth of cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolaus Berndt, Johannes Eckstein, Niklas Heucke, Tilo Wuensch, Robert Gajowski, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhuetter
Summary: Metabolic reprogramming is a common feature of cancer cells, but there is no uniform metabolic program for different tumors. A systems biology approach was used to study metabolic changes in hepatocellular carcinoma (HCC), revealing significant heterogeneity in glucose uptake and release among tumors, as well as variations in lactate uptake, glycogen content, and drug sensitivity. This comprehensive and quantitative characterization of HCC metabolism may aid in evaluating pharmacological therapies targeting HCC metabolic processes.
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Ning Zhu, Xiaohong Chen, Junjun Zhao, Lijuan Fang, Yingmin Yao, Feifei Zhou, Liang Tao, Qiuran Xu
Summary: This study demonstrates that LINC00674, a HIF-1 target gene induced by hypoxia, plays a pro-proliferative and pro-metastatic role in hepatocellular carcinoma (HCC) by activating the NOX1/mTOR signaling pathway. LINC00674 knockdown inhibits HCC cell migration, proliferation, and invasion, and represses the mTOR signaling pathway. Furthermore, LINC00674 positively regulates NOX1 expression to promote the malignant behaviors of HCC cells.
Article
Immunology
Zixi Wang, Di Guan, Jianxin Huo, Subhra K. Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu, Kong-Peng Lam
Summary: The study demonstrates that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, crucial for their enhanced effector functions. Mechanistically, it is revealed that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Peng Du, Kaifeng Luo, Guoyong Li, Jisheng Zhu, Qi Xiao, Yong Li, Xingjian Zhang
Summary: The study revealed that PRMT4 is highly expressed in HCC and closely associated with clinical characteristics and prognosis of liver cancer. PRMT4 promotes proliferation, migration, and invasion of HCC cells by activating the AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Zhongmin Sui, Chaoqing Wei, Xuan Wang, Huihui Zhou, Chengdong Liu, Kangsen Mai, Gen He
Summary: Ammonia has significant impacts on the growth and health of crustaceans, leading to oxidative stress and metabolic disorders. However, little is known about its effects on nutrient metabolism and signaling pathways. This study provides important insights into the metabolic responses and nutrient signaling under ammonia stress, enhancing our understanding of the physiological responses and growth performance in shrimp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Jing Man, Wanbiao Zhou, Shi Zuo, Xueke Zhao, Qiang Wang, Huaxing Ma, Hai-Yang Li
Summary: TANGO1 promotes hepatocellular carcinoma by activating the PI3K/AKT/mTOR signaling pathway through interaction with NRTN, leading to increased proliferation and EMT. The TANGO1/NRTN axis may serve as a potential therapeutic target for HCC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Developmental Biology
Hannah Brunsdon, Alessandro Brombin, Samuel Peterson, John H. Postlethwait, E. Elizabeth Patton
Summary: Melanocyte stem cells in zebrafish undergo a two-step cell state transition during regeneration, and the reaction products of Aldh2 enzymes meet the metabolic demands of stem cells in the regeneration process.
Article
Medicine, General & Internal
Sijia Ge, Hua Huang, Wei Huang, Ran Ji, Jing Chen, Shuzhen Wu, Liyang Wang, Tianxin Huang, Yu Sheng, Haiou Yan, Cuihua Lu, Lin Ma
Summary: This study found that the high expression of PSME4 promotes the proliferation of hepatocellular carcinoma cells via the mTOR signaling pathway and has an adverse impact on prognosis. This suggests that PSME4 may be a potential marker for early diagnosis and prognosis of hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Liyu Deng, Jidong Chen, Bin Chen, Ting Wang, Lei Yang, Jing Liao, Junbo Yi, Yuqin Chen, Jian Wang, John Linneman, Yanqin Niu, Deming Gou
Summary: This study reveals that the long noncoding RNA lncPTSR is involved in pulmonary artery remodeling by modulating the expression of PMCA4 and intracellular calcium homeostasis, providing a promising therapeutic target for the treatment of pulmonary hypertension.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Oncology
Ridho Assidicky, Unal Metin Tokat, Ibrahim Oguzhan Tarman, Ozge Saatci, Pelin Gulizar Ersan, Umar Raza, Hasan Ogul, Yasser Riazalhosseini, Tolga Can, Ozgur Sahin
Summary: In this study, we identified fibronectin (FN1) as a central driver gene in chemoresistance. Overexpression of miR-326 reversed FN1-driven chemoresistance by targeting the FN1 receptor, ITGA5. miR-326 expression was downregulated by increased hypoxia/HIF1A and ECM stiffness in chemoresistant tumors, leading to upregulation of ITGA5 and activation of the downstream FAK/Src signaling pathways. Overexpression of miR-326 or inhibition of ITGA5 overcame FN1-driven chemotherapy resistance in vitro by inhibiting the FAK/Src pathway and potentiated the efficacy of chemotherapy in vivo. Importantly, lower expression of miR-326 or higher levels of predicted miR-326 target genes were significantly associated with worse overall survival in chemotherapy-treated TNBC patients.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Oncology
Yanxia Jin, Weidong Wang, Qiyun Wang, Yueyang Zhang, Kashif Rafiq Zahid, Umar Raza, Yongsheng Gong
Summary: This review summarizes the expression level, glycosylation modification, and biological characteristics of the glycoprotein AACT in inflammation, neurodegenerative and elderly diseases, and tumorigenesis. AACT's dysregulation and glycosylation levels are associated with tumor progression and recurrence, making it a potential biomarker for tumor monitoring. Additionally, AACT's aberrant expression in cancer may be due to genetic alterations and/or immune regulation, and it may serve as a diagnostic or prognostic biomarker or therapeutic target in tumors. The review confirms the key roles of AACT in tumorigenesis, suggesting its potential importance as a biomarker for tumor diagnosis and prognosis, as well as a therapeutic target for human diseases.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jun Wang, Yanqin Niu, Lingjie Luo, Zefeng Lu, Qinghua Chen, Shasha Zhang, Qianwen Guo, Li Li, Deming Gou
Summary: A ceRNA regulatory network was constructed in the pulmonary arteries of HPH rats, identifying 10 hub miRNAs and their corresponding interacting lncRNAs, circRNAs, and mRNAs. The expression patterns of selected DERNAs were validated to be consistent with the sequencing result. POSTN, LTBP2, SPP1, and LSAMP were suggested as potential diagnostic biomarkers and therapeutic targets for PAH.
CELL AND BIOSCIENCE
(2022)
Review
Oncology
Kashif Rafiq Zahid, Umar Raza, Soumya Tumbath, Lingxiang Jiang, Wenjuan Xu, Xiumei Huang
Summary: This review provides an update on the contribution of neutrophils in immune suppression and tumor progression. It discusses the molecular pathways through which neutrophils assist cancer progression and orchestrate immune evasion, as well as the potential of neutrophil antagonism to enhance the efficacy of immune checkpoint blockade therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Ruchit Patel, Shun Yao, Raymond Y. Huang, Wenya Linda Bi
Summary: Radiomics is a powerful technology in quantitative imaging analysis for assessing molecular correlates and guiding clinical decision-making. This study systematically reviewed meningioma radiomics analyses and found that the majority of research focused on technical model development rather than clinical applications. The quality of the studies was overall low, indicating the need for improvement in data quality and engagement in prospective trials.
Article
Biophysics
Jianzhong He, Shun Yao, Qingrun Zeng, Jinping Chen, Tian Sang, Lei Xie, Yiang Pan, Yuanjing Feng
Summary: The human visual pathway can be reconstructed noninvasively using diffusion MRI tractography. However, this process is challenging due to the complex fiber geometries and the skull base environment. In this paper, a unified global tractography framework is proposed to automatically reconstruct the visual pathway.
NMR IN BIOMEDICINE
(2023)
Article
Geriatrics & Gerontology
Yaqiong Xiao, Jiaojian Wang, Kaiyu Huang, Lei Gao, Shun Yao
Summary: This study investigates the grey matter atrophy, structural covariance connectivity abnormalities, and the correlations between grey matter atrophy and cognitive decline in Alzheimer's disease (AD) patients. The results show significant grey matter atrophy in multiple brain regions of AD patients, and the decrease in grey matter volume is positively correlated with cognitive decline. Additionally, abnormal structural covariance connectivity is observed in AD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yuanyuan Hu, Hao Zhou, Jinxu Huang, Guangxing Pan, Hao Wang, Tiansheng Wang, Congwei Yu, Ling Zhang, Deming Gou, Jiaheng Zhang
Summary: The development of new structural agents with significant antimicrobial potential is necessary due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics. A novel class of 2-hydroxypropyl group linked derivatives of indole azoles was found to have excellent antibacterial capacity against MRSA. Compound 4a showed low toxicity and did not cause drug-resistance in MRSA after multiple generations. Its mechanism of action involves infiltration of the MRSA membrane and insertion into MRSA DNA to prevent replication, resulting in strong inhibition of the bacteria. The highly active derivative 4a also responded well to inflammatory factors and had the potential to be a multifunctional anti-MRSA agent.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Neurosciences
Yaqiong Xiao, Liangjun Liao, Kaiyu Huang, Shun Yao, Lei Gao
Summary: This study investigates the relationship between hippocampal volumetric integrity and brain atrophy during AD progression, and finds that hippocampal atrophy is associated with cognitive decline. The study also reveals stronger connections between the hippocampus and other brain regions in MCI and AD patients. These findings have important clinical implications for the prognosis of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Computer Science, Information Systems
Yu Luo, Manting Wei, Si Li, Jie Ling, Guobo Xie, Shun Yao
Summary: Multi-contrast magnetic resonance imaging (MRI) is commonly used for clinical diagnosis, but obtaining multi-contrast MR data is time-consuming and may result in motion artifacts. To improve image quality in limited acquisition time, we propose a model that reconstructs images from under-sampled k-space data using fully-sampled data from another contrast of the same anatomy. The model incorporates similarity regularization of the co-supports across multi-contrasts, leading to a mixed integer optimization problem. Experimental results show that our model outperforms other state-of-the-art methods in terms of quantitative metrics and visual performance at various sampling ratios.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqi Wang, Chengbin Duan, Shun Yao, Jinping Chen, Shaolin Zhang, Zongming Wang, Bin Hu, Zhigang Mao, Haijun Wang, Yonghong Zhu, Wenli Chen
Summary: Monitoring postoperative biochemical levels in acromegaly patients, especially those in developing countries, is a challenge. In this study, a mobile and low-cost method using MobileNetv2-based transfer learning algorithm was established to predict biochemical remission. The algorithm showed high accuracy in predicting biochemical remission in both the training and validation cohorts.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Microbiology
Lingjie Luo, Haoyang Yin, Deming Gou
Summary: Dysbiosis of gut microbiota and metabolites is found in pulmonary hypertension patients and rodent models. The exact changes in gut microbiota during the development of pulmonary hypertension remain unclear, as does the function of gut microbiota. This study demonstrated disrupted gut microbiota in rats with various induced forms of pulmonary hypertension, and showed dynamic changes in the gut microbiota during disease progression. Specific plasma biomarkers and a disease-associated network linking Streptococcus with pulmonary hypertension-associated metabolites were identified.
Article
Cardiac & Cardiovascular Systems
Lei Yang, Jinglin Tian, Jun Wang, Jie Zeng, Ting Wang, Boya Lin, John Linneman, Li Li, Yanqin Niu, Deming Gou, Yunhui Zhang
Summary: In this study, it was found that EP300 expression was increased in the MCT-induced PH model in rats, and knockdown of EP300 exacerbated PH and promoted the proliferation of PASMCs. Furthermore, EGR1 upregulated the expression of EP300 and provided protection from MCT-induced PH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqi Wang, Chengbin Duan, Shun Yao, Jinping Chen, Shaolin Zhang, Zongming Wang, Bin Hu, Zhigang Mao, Haijun Wang, Yonghong Zhu, Wenli Chen
Summary: This study presents a mobile and low-cost method to predict biochemical remission in acromegaly patients after surgery. The results show that the MobileNetv2-based transfer learning algorithm can accurately predict the likelihood of biochemical remission in acromegaly patients, providing a potential solution for those who live in remote areas or regions with limited medical resources.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)