Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

(2019) Deli Zhang et al.   Nature Communications

Insights into ablation of persistent atrial fibrillation: Lessons from 6-year clinical outcomes

(2018) Stephanie Brooks et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation

(2017) Marit Wiersma et al.   Journal of the American Heart Association

Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia

(2017) Hongting Zhao et al.   Scientific Reports

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

(2016) Mathias Mericskay   Archives of Cardiovascular Diseases

Predicting atrial fibrillation ablation outcome: The CAAP-AF score

(2016) Roger A. Winkle et al.   HEART RHYTHM

Long-term clinical outcomes of focal impulse and rotor modulation for treatment of atrial fibrillation: A multicenter experience

(2016) Eric Buch et al.   HEART RHYTHM

Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation

(2015) Jordi Heijman et al.   BASIC RESEARCH IN CARDIOLOGY

The effect of mitochondrial calcium uniporter on mitochondrial fission in hippocampus cells ischemia/reperfusion injury

(2015) Lantao Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury

(2015) CATERINA CONSTANTINOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The mitochondrial Ca2+ uniporter complex

(2015) J. Kevin Foskett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling

(2015) Samineh Deheshi et al.   JOURNAL OF NEUROCHEMISTRY

HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

(2015) Eva A. H. Lanters et al.   Journal of Translational Medicine

Erratum: Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2015) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response

(2015) Roelien A. M. Meijering et al.   PLoS One

Functional and Structural Alterations of Cardiac and Skeletal Muscle Mitochondria in Heart Failure Patients

(2014) Gustavo Guzmán Mentesana et al.   ARCHIVES OF MEDICAL RESEARCH

Effects of Regional Mitochondrial Depolarization on Electrical Propagation

(2014) Lufang Zhou et al.   Circulation-Arrhythmia and Electrophysiology

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

(2014) H H Szeto et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mitochondrial injury and dysfunction in hypertension-induced cardiac damage

(2014) A. Eirin et al.   EUROPEAN HEART JOURNAL

Essential Role of Mitochondrial Ca2+Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells

(2014) Xianglan Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epidemiology of atrial fibrillation: European perspective

(2014) Massimo Zoni-Berisso et al.   Clinical Epidemiology

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation

(2013) Deli Zhang et al.   CIRCULATION

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

An efficient extraction method for quantitation of adenosine triphosphate in mammalian tissues and cells

(2012) Junji Chida et al.   ANALYTICA CHIMICA ACTA

Novel molecular targets for atrial fibrillation therapy

(2012) Dobromir Dobrev et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

(2012) I. Drago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of atrial Ca2+ handling as cause and consequence of atrial fibrillation

(2011) M. Greiser et al.   CARDIOVASCULAR RESEARCH

Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation

(2011) Deli Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes

(2011) Lei Ke et al.   PLoS One

Novel Mitochondria-Targeted Antioxidant Peptide Ameliorates Burn-Induced Apoptosis and Endoplasmic Reticulum Stress in the Skeletal Muscle of Mice

(2011) Hyung-yul Lee et al.   SHOCK

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Electropathological Substrate of Longstanding Persistent Atrial Fibrillation in Patients With Structural Heart Disease

(2010) Natasja M.S. de Groot et al.   CIRCULATION

SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery

(2010) Huan Ling Liang et al.   FREE RADICAL BIOLOGY AND MEDICINE

In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both

(2010) Ricardo Caballero et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Left versus right atrial difference in dominant frequency, K+ channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery

(2009) Michael F. Swartz et al.   HEART RHYTHM

The “Second Factor”: A First Step Toward Diagnosing the Substrate of Atrial Fibrillation?**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

(2009) Maurits Allessie   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Paroxysmal Lone Atrial Fibrillation Is Associated With an Abnormal Atrial Substrate

(2009) Martin K. Stiles et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

(2008) Lei Ke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL