Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)

CETSA® beyond soluble targets: a broad application to multi-pass transmembrane proteins

(2019) Aarti Kawatkar et al.   ACS Chemical Biology

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

(2018) Mari Hashimoto et al.   ACS Chemical Biology

Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells

(2018) Huei-Yu Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition

(2016) Fei Wang et al.   CANCER BIOLOGY & THERAPY

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)

(2016) Ming-Hung Lin et al.   MOLECULES

Capsaicin: From Plants to a Cancer-Suppressing Agent

(2016) Angela Chapa-Oliver et al.   MOLECULES

Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways

(2016) Kaiyu Qian et al.   MOLECULES

Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death

(2015) Yi-Hui Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53

(2014) Junzhe Jin et al.   International Journal of Biological Sciences

Dysregulated miR-34a–SIRT1–Acetyl p65 Axis Is a Potential Mediator of Immune Activation in the Colon during Chronic Simian Immunodeficiency Virus Infection of Rhesus Macaques

(2014) Mahesh Mohan et al.   JOURNAL OF IMMUNOLOGY

CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT

(2014) K. C. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells

(2013) Chia-Han Lin et al.   BMC Complementary and Alternative Medicine

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells

(2012) Zih-Ming Zeng et al.   EXPERIMENTAL CELL RESEARCH

Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons

(2012) Jong-Geol Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells

(2012) Dong Chen et al.   INTERNATIONAL JOURNAL OF UROLOGY

Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo

(2012) Nei-Chi Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

(2012) Keith Bley et al.   TOXICOLOGIC PATHOLOGY

Capsaicin-Induced Apoptosis of FaDu Human Pharyngeal Squamous Carcinoma Cells

(2012) Thanh-Do Le et al.   YONSEI MEDICAL JOURNAL

Down-Regulation of Tumor-Associated NADH Oxidase, tNOX (ENOX2), Enhances Capsaicin-Induced Inhibition of Gastric Cancer Cell Growth

(2011) His-Ming Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Effect of Ccapsaicin on tNOX (ENOX2) protein expression in stomach cancer cells

(2009) Hsi-Ming Wang et al.   BIOFACTORS

Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway

(2009) N H Thoennissen et al.   ONCOGENE

Stress-induced down-regulation of tumor-associated NADH oxidase during apoptosis in transformed cells

(2008) Liang-Chi Mao et al.   FEBS LETTERS

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac

(2007) Shan-Chi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS