IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-dose interleukin-2 therapy for the treatment of systemic lupus erythematosus

(2018) Jens Y. Humrich et al.   CURRENT OPINION IN RHEUMATOLOGY

IL-2/anti-IL-2 complexes ameliorate lupus nephritis by expansion of CD4+CD25+Foxp3+ regulatory T cells

(2017) Ji-Jing Yan et al.   KIDNEY INTERNATIONAL

Low-dose IL-2 therapy — a complex scenario that remains to be further explored

(2017) Jens Y. Humrich et al.   Nature Reviews Rheumatology

Restoring regulation – IL-2 therapy in systemic lupus erythematosus

(2016) Jens Y. Humrich et al.   Expert Review of Clinical Immunology

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

The rise of IL-2 therapy — a novel biologic treatment for SLE

(2016) Jens Y. Humrich et al.   Nature Reviews Rheumatology

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

(2015) Caroline von Spee-Mayer et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE

(2015) Jens Y Humrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-2: Biology, Design and Application

(2015) Natalia Arenas-Ramirez et al.   TRENDS IN IMMUNOLOGY

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8−IL-17–Producing T Cells

(2014) Masayuki Mizui et al.   JOURNAL OF IMMUNOLOGY

Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus

(2012) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

CD44 Regulates Survival and Memory Development in Th1 Cells

(2010) Bas J.G. Baaten et al.   IMMUNITY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients

(2009) P. Enghard et al.   ARTHRITIS AND RHEUMATISM

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Changes in the Incidence of Endstage Renal Disease Due to Lupus Nephritis in the United States, 1996-2004

(2008) Michael M. Ward   JOURNAL OF RHEUMATOLOGY

Leukocytes and the kidney contribute to interstitial inflammation in lupus nephritis

(2007) L. Adalid-Peralta et al.   KIDNEY INTERNATIONAL