The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

Cancer statistics, 2014

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Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase

(2013) Yuli Lin et al.   Molecular Cancer

Wnt Pathway Activation Predicts Increased Risk of Tumor Recurrence in Patients With Stage I Nonsmall Cell Lung Cancer

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Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

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Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

(2009) Zhipeng Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo

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Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

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Wnt signaling and stem cell control

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