N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

(2019) Annika Behrendt et al.   NEUROBIOLOGY OF DISEASE

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

(2018) James P. Quinn et al.   JOURNAL OF ALZHEIMERS DISEASE

Characteristics of TBS-Extractable Hyperphosphorylated Tau Species: Aggregation Intermediates in rTg4510 Mouse Brain

(2018) Naruhiko Sahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

(2018) Zhi-Hao Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparaginyl endopeptidase cleaves TDP-43 in brain

(2012) Jeremy H. Herskowitz et al.   PROTEOMICS

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile

(2011) Elfriede Dall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

(2010) Stephen P. Matthews et al.   JOURNAL OF IMMUNOLOGY

Early behavioural markers of disease in P301S tau transgenic mice

(2009) Maria Luisa Scattoni et al.   BEHAVIOURAL BRAIN RESEARCH

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability

(2009) Laura Gasparini et al.   NEUROBIOLOGY OF AGING

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL