Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

Restriction of HIV-1 and other retroviruses by TRIM5

(2019) Barbie K. Ganser-Pornillos et al.   NATURE REVIEWS MICROBIOLOGY

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

(2018) Chantal L Márquez et al.   eLife

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

(2018) Donna L Mallery et al.   eLife

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating

(2018) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

Inositol phosphates are assembly co-factors for HIV-1

(2018) Robert A. Dick et al.   NATURE

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation

(2018) Simone Mattei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A general model for retroviral capsid pattern recognition by TRIM5 proteins

(2017) Jonathan M. Wagner et al.   JOURNAL OF VIROLOGY

Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly

(2017) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

Early cytoplasmic uncoating is associated with infectivity of HIV-1

(2017) João I. Mamede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

(2017) Marcin D. Roganowicz et al.   PLoS Pathogens

In Situ High Temperature Atomic Level Studies of Large Closed Grain Boundary Loops in Graphene

(2016) Chuncheng Gong et al.   ACS Nano

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription

(2016) Ophélie Cosnefroy et al.   Retrovirology

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Retrovirus maturation—an extraordinary structural transformation

(2016) Simone Mattei et al.   Current Opinion in Virology

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

(2016) Jonathan M Wagner et al.   eLife

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

(2016) Yen-Li Li et al.   eLife

TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization

(2015) Edward M. Campbell et al.   JOURNAL OF VIROLOGY

Large-scale experimental and theoretical study of graphene grain boundary structures

(2015) Colin Ophus et al.   PHYSICAL REVIEW B

Recognition of the HIV Capsid by the TRIM5α Restriction Factor Is Mediated by a Subset of Pre-Existing Conformations of the TRIM5α SPRY Domain

(2014) Dmytro B. Kovalskyy et al.   BIOCHEMISTRY

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

(2014) David C. Goldstone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer

(2014) J. G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhesus Monkey TRIM5α SPRY Domain Recognizes Multiple Epitopes That Span Several Capsid Monomers on the Surface of the HIV-1 Mature Viral Core

(2013) Nikolaos Biris et al.   JOURNAL OF MOLECULAR BIOLOGY

A Comparison of Murine Leukemia Viruses That Escape from Human and Rhesus Macaque TRIM5 s

(2013) S. Ohkura et al.   JOURNAL OF VIROLOGY

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

(2013) Sebla B. Kutluay et al.   PLoS Pathogens

Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

(2013) Kevin R. McCarthy et al.   PLoS Pathogens

Dynamo: A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments

(2012) Daniel Castaño-Díez et al.   JOURNAL OF STRUCTURAL BIOLOGY

Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core

(2012) Y. Yang et al.   JOURNAL OF VIROLOGY

Structural insight into HIV-1 capsid recognition by rhesus TRIM5 

(2012) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the rhesus monkey TRIM5  PRYSPRY domain, the HIV capsid recognition module

(2012) N. Biris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

(2011) Gongpu Zhao et al.   PLoS Pathogens

Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

(2011) Sadayuki Ohkura et al.   PLoS Pathogens

TRIM5  Disrupts the Structure of Assembled HIV-1 Capsid Complexes In Vitro

(2010) L. R. Black et al.   JOURNAL OF VIROLOGY

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α

(2010) Ayumu Kuroishi et al.   Retrovirology

Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction

(2010) Ken Kono et al.   Retrovirology

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

An Invariant Surface Patch on the TRIM5  PRYSPRY Domain Is Required for Retroviral Restriction but Dispensable for Capsid Binding

(2009) S. Sebastian et al.   JOURNAL OF VIROLOGY

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α

(2008) Edward M. Campbell et al.   JOURNAL OF CELL BIOLOGY

Structure of B-MLV Capsid Amino-terminal Domain Reveals Key Features of Viral Tropism, Gag Assembly and Core Formation

(2008) Gulnahar B. Mortuza et al.   JOURNAL OF MOLECULAR BIOLOGY

Biochemical Characterization of a Recombinant TRIM5  Protein That Restricts Human Immunodeficiency Virus Type 1 Replication

(2008) C. R. Langelier et al.   JOURNAL OF VIROLOGY