TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction

(2017) Rajan Lamichhane et al.   VIROLOGY

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α

(2016) Jeremy R. Keown et al.   Scientific Reports

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

(2016) Jonathan M Wagner et al.   eLife

TRIM5  requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

(2015) A. J. Fletcher et al.   EMBO JOURNAL

TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization

(2015) Edward M. Campbell et al.   JOURNAL OF VIROLOGY

Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers

(2015) Christopher Weinert et al.   Scientific Reports

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Structural Insight into HIV-1 Restriction by MxB

(2014) Jennifer L. Fribourgh et al.   Cell Host & Microbe

Structural insights into the TRIM family of ubiquitin E3 ligases

(2014) Yang Li et al.   CELL RESEARCH

Restriction of HIV-1 by Rhesus TRIM5  Is Governed by Alpha Helices in the Linker2 Region

(2014) J. Sastri et al.   JOURNAL OF VIROLOGY

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

(2014) David C. Goldstone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer

(2014) J. G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Naturally Occurring Single Amino Acid Substitution in Human TRIM5α Linker Region Affects Its Anti-HIV Type 1 Activity and Susceptibility to HIV Type 1 Infection

(2013) Emi E. Nakayama et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Allosteric Control of Syntaxin 1a by Munc18-1: Characterization of the Open and Closed Conformations of Syntaxin

(2013) Damian Dawidowski et al.   BIOPHYSICAL JOURNAL

Rhesus Monkey TRIM5α SPRY Domain Recognizes Multiple Epitopes That Span Several Capsid Monomers on the Surface of the HIV-1 Mature Viral Core

(2013) Nikolaos Biris et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

DEER Distance Measurements on Proteins

(2012) Gunnar Jeschke   Annual Review of Physical Chemistry

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL

(2012) Gregor Hagelueken et al.   APPLIED MAGNETIC RESONANCE

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

(2012) K. Lee et al.   JOURNAL OF VIROLOGY

Diverse HIV viruses are targeted by a conformationally dynamic antiviral

(2012) Matthew E C Caines et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insight into HIV-1 capsid recognition by rhesus TRIM5 

(2012) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the rhesus monkey TRIM5  PRYSPRY domain, the HIV capsid recognition module

(2012) N. Biris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants of the Higher Order Association of the Restriction Factor TRIM5α and Other Tripartite Motif (TRIM) Proteins

(2011) Xing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

(2011) Gongpu Zhao et al.   PLoS Pathogens

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of residues within the L2 region of rhesus TRIM5α that are required for retroviral restriction and cytoplasmic body localization

(2010) Jaya Sastri et al.   VIROLOGY

A B-Box 2 Surface Patch Important for TRIM5  Self-Association, Capsid Binding Avidity, and Retrovirus Restriction

(2009) F. Diaz-Griffero et al.   JOURNAL OF VIROLOGY

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

Active site remodeling switches HIV specificity of antiretroviral TRIMCyp

(2009) Amanda J Price et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein

(2009) Felix F. Vajdos et al.   PROTEIN SCIENCE

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α

(2008) Edward M. Campbell et al.   JOURNAL OF CELL BIOLOGY

The TRIM5  B-Box 2 Domain Promotes Cooperative Binding to the Retroviral Capsid by Mediating Higher-Order Self-Association

(2008) X. Li et al.   JOURNAL OF VIROLOGY

Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5  Protein

(2008) A. K. Kar et al.   JOURNAL OF VIROLOGY

Biochemical Characterization of a Recombinant TRIM5  Protein That Restricts Human Immunodeficiency Virus Type 1 Replication

(2008) C. R. Langelier et al.   JOURNAL OF VIROLOGY