Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer

Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells

(2015) Gao Huasong et al.   BRAIN RESEARCH

Standard loading controls are not reliable for Western blot quantification across brain development or in pathological conditions

(2015) Kate Goasdoue et al.   ELECTROPHORESIS

Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation

(2015) P. J. Yao et al.   JOURNAL OF NEUROSCIENCE

Substantial contribution of extrinsic risk factors to cancer development

(2015) Song Wu et al.   NATURE

Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei

(2015) Christopher P. Landowski et al.   PLoS One

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Protease Serine 4 Promotes Thyroid Cancer Proliferation via CREB Phosphorylation

(2015) Hongyu Guan et al.   THYROID

Vegetarian Dietary Patterns and the Risk of Colorectal Cancers

(2015) Michael J. Orlich et al.   JAMA Internal Medicine

Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway

(2014) Mazura Pisar et al.   BRAIN RESEARCH

MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

(2014) Yichen Song et al.   EXPERIMENTAL CELL RESEARCH

Prb1, a subtilisin-like protease, is required for virulence and phenotypical traits in the chestnut blight fungus

(2014) Liming Shi et al.   FEMS MICROBIOLOGY LETTERS

Microbiota organization is a distinct feature of proximal colorectal cancers

(2014) Christine M. Dejea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents

(2014) Alfonso Clemente   WORLD JOURNAL OF GASTROENTEROLOGY

Imbalanced Matriptase Pericellular Proteolysis Contributes to the Pathogenesis of Malignant B-Cell Lymphomas

(2013) Feng-Pai Chou et al.   AMERICAN JOURNAL OF PATHOLOGY

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

(2013) Caroline M. Forrest et al.   BRAIN RESEARCH

HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase

(2013) C-H Tsai et al.   ONCOGENE

Cathepsins and pancreatic cancer: The 2012 update

(2013) Sara Sulpizio et al.   PANCREATOLOGY

New 26S Proteasome Inhibitors with High Selectivity for Chymotrypsin-Like Activity and p53-Dependent Cytotoxicity

(2012) Paul M. Neilsen et al.   ACS Chemical Biology

Heterologous expression, purification, and properties of a chymotrypsin inhibitor isolated from potatoes

(2012) I. A. Parfenov et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Chymotrypsin-like serine proteinases are involved in the maintenance of cell viability

(2012) K.L. Moffitt et al.   BIOCHIMIE

The anti-proliferative effect of TI1B, a major Bowman–Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition

(2012) Alfonso Clemente et al.   BRITISH JOURNAL OF NUTRITION

Deleted in Colorectal Cancer (DCC) Pathfinding: Axon Guidance Gene Finally Turned Tumor Suppressor

(2012) Molly Duman-Scheel   CURRENT DRUG TARGETS

Neogenin regulates sonic hedgehog pathway activity during digit patterning

(2012) Mingi Hong et al.   DEVELOPMENTAL DYNAMICS

Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons

(2012) N. Mitchell et al.   JOURNAL OF CELL SCIENCE

Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness

(2012) Takashi Baba et al.   JOURNAL OF PATHOLOGY

Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin

(2012) Donghui Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wheat Subtilisin/Chymotrypsin Inhibitor (WSCI) as a scaffold for novel serine protease inhibitors with a given specificity

(2012) Francesca Tedeschi et al.   Molecular BioSystems

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

(2012) Paul Krimpenfort et al.   NATURE

Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin

(2012) C.M. Forrest et al.   NEUROSCIENCE

Serine Protease PRSS23 Is Upregulated by Estrogen Receptor α and Associated with Proliferation of Breast Cancer Cells

(2012) Hau-Shien Chan et al.   PLoS One

Down-Regulation of Neogenin Accelerated Glioma Progression through Promoter Methylation and Its Overexpression in SHG-44 Induced Apoptosis

(2012) Xinmin Wu et al.   PLoS One

Molecular Profiling of Colon Tumors: The Search for Clinically Relevant Biomarkers of Progression, Prognosis, Therapeutics, and Predisposition

(2011) Manny D. Bacolod et al.   ANNALS OF SURGICAL ONCOLOGY

The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor

(2011) Adrienne VanZomeren-Dohm et al.   BMC DEVELOPMENTAL BIOLOGY

Adaptive changes of pancreatic protease secretion to a short-term vegan diet: influence of reduced intake and modification of protein

(2011) Jaroslaw Walkowiak et al.   BRITISH JOURNAL OF NUTRITION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bowman-Birk Inhibitors from Legumes and Human Gastrointestinal Health: Current Status and Perspectives

(2011) Alfonso Clemente et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Netrins: versatile extracellular cues with diverse functions

(2011) K. L. W. Sun et al.   DEVELOPMENT

Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer

(2011) Marie–May Coissieux et al.   GASTROENTEROLOGY

The UNC5C Netrin Receptor Regulates Dorsal Guidance of Mouse Hindbrain Axons

(2011) D. Kim et al.   JOURNAL OF NEUROSCIENCE

DCC constrains tumour progression via its dependence receptor activity

(2011) Marie Castets et al.   NATURE

Structure and properties of the potato chymotrypsin inhibitor

(2011) Tatiana A. Valueva et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Increased plasma proteasome chymotrypsin-like activity in patients with advanced solid tumors

(2011) Dominika Hempel et al.   TUMOR BIOLOGY

Matriptase Is Involved in ErbB-2-Induced Prostate Cancer Cell Invasion

(2010) Shang-Ru Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Optimization of the scratch assay for in vitro skeletal muscle wound healing analysis

(2010) K.P. Goetsch et al.   ANALYTICAL BIOCHEMISTRY

An agarose spot assay for chemotactic invasion

(2010) Helen Wiggins et al.   BIOTECHNIQUES

Apoptosis and lysosome membrane permeabilization induction on breast cancer cells by an anticarcinogenic Bowman–Birk protease inhibitor from Vigna unguiculata seeds

(2010) Graziella Anselmo Joanitti et al.   CANCER LETTERS

Endogenous Expression of Matriptase in Neural Progenitor Cells Promotes Cell Migration and Neuron Differentiation

(2010) Jung-Da Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for RhoB in Synaptic Plasticity and the Regulation of Neuronal Morphology

(2010) K. McNair et al.   JOURNAL OF NEUROSCIENCE

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

Dependence receptors: a new paradigm in cell signaling and cancer therapy

(2010) D Goldschneider et al.   ONCOGENE

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

The ratio of ‘deleted in colorectal cancer’ to ’uncoordinated-5A‘ netrin-1 receptors on the growth cone regulates mossy fibre directionality

(2009) Rieko Muramatsu et al.   BRAIN

Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth

(2009) Mariêve Picard et al.   CELLULAR SIGNALLING

Netrin-1 and its dependence receptors as original targets for cancer therapy

(2009) Patrick Mehlen et al.   CURRENT OPINION IN ONCOLOGY

Role of CpSUB1, a Subtilisin-Like Protease, inCryptosporidium parvumInfection In Vitro

(2009) Jane W. Wanyiri et al.   EUKARYOTIC CELL

Bowman-Birk inhibitors in lentil: Heterologous expression, functional characterisation and anti-proliferative properties in human colon cancer cells

(2009) Pasqua Caccialupi et al.   FOOD CHEMISTRY

Frequent Inactivation of Axon Guidance Molecule RGMA in Human Colon Cancer Through Genetic and Epigenetic Mechanisms

(2009) Vivian S.W. Li et al.   GASTROENTEROLOGY

Characterization of bacterial strains isolated from a beef-processing plant following cleaning and disinfection — Influence of isolated strains on biofilm formation by Sakaï and EDL 933 E. coli O157:H7

(2009) Nesrine Marouani-Gadri et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Netrin-1 acts as a survival factor for aggressive neuroblastoma

(2009) Céline Delloye-Bourgeois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth

(2009) Ting-Yu Kuo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The cytotoxic effect of Bowman-Birk isoinhibitors, IBB1 and IBBD2, from soybean (Glycine max) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases

(2009) Alfonso Clemente et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Trypsin-Chymotrypsin Inhibitors from Vigna mungo Seeds

(2009) Allen Cheung et al.   PROTEIN AND PEPTIDE LETTERS

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

(2008) E. Ostermann et al.   CLINICAL CANCER RESEARCH

The Biochemical and Functional Food Properties of the Bowman-Birk Inhibitor

(2008) Jack N. Losso   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Differential Effects of Serine Proteases on the Migration of Normal and Tumor Cells: Implications for Tumor Microenvironment

(2008) Kirsten L. Elzer et al.   INTEGRATIVE CANCER THERAPIES

Characterization of spore forming Bacilli isolated from the human gastrointestinal tract

(2008) S. Fakhry et al.   JOURNAL OF APPLIED MICROBIOLOGY

The Neogenin Intracellular Domain Regulates Gene Transcription via Nuclear Translocation

(2008) D. Goldschneider et al.   MOLECULAR AND CELLULAR BIOLOGY

Bacillus subtilis isolated from the human gastrointestinal tract

(2008) Huynh A. Hong et al.   RESEARCH IN MICROBIOLOGY