Stochastic epigenetic outliers can define field defects in cancer

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

(2016) Andrew E Teschendorff et al.   Nature Communications

Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues

(2016) Niya Wang et al.   Scientific Reports

An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

(2015) Tian Yuan et al.   PLoS Genetics

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

On the potential of models for location and scale for genome-wide DNA methylation data

(2014) Simone Wahl et al.   BMC BIOINFORMATICS

Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy

(2014) Sandro Santagata et al.   Expert Review of Anticancer Therapy

Taxonomy of breast cancer based on normal cell phenotype predicts outcome

(2014) Sandro Santagata et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine

(2014) A. P. Feinberg   JOURNAL OF INTERNAL MEDICINE

The Dynamics of DNA Methylation Covariation Patterns in Carcinogenesis

(2014) Andrew E. Teschendorff et al.   PLoS Computational Biology

A genome-wide methylation study on obesity

(2013) Xiaojing Xu et al.   Epigenetics

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Epigenetic field defects in progression to cancer

(2013) Carol Bernstein   World Journal of Gastrointestinal Oncology

Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions

(2012) A. E. Teschendorff et al.   BIOINFORMATICS

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

(2012) Andrew E Teschendorff et al.   Genome Medicine

Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies

(2011) Andrew E. Teschendorff et al.   BIOINFORMATICS

DNA methylation profiling reveals a predominant immune component in breast cancers

(2011) Sarah Dedeurwaerder et al.   EMBO Molecular Medicine

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Epigenetic variation and cellular Darwinism

(2011) Jean-Pierre Issa   NATURE GENETICS

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Early-stage formation of an epigenetic field defect in a mouse colitis model and non-essential roles of T- and B-cells in DNA methylation induction

(2011) M Katsurano et al.   ONCOGENE

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

(2009) Andrew E. Teschendorff et al.   PLoS One

Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

(2009) A. P. Feinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA