IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation

Persistent stimulation with Mycobacterium tuberculosis antigen impairs the proliferation and transcriptional program of hematopoietic cells in bone marrow

(2019) Fei Li et al.   MOLECULAR IMMUNOLOGY

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells

(2018) Chunxiang Bai et al.   TUBERCULOSIS

Therapeutic effects of recombinant human interleukin 2 as adjunctive immunotherapy against tuberculosis: A systematic review and meta-analysis

(2018) Ruimei Zhang et al.   PLoS One

Subunit Vaccines Consisting of Antigens from Dormant and Replicating Bacteria Show Promising Therapeutic Effect against Mycobacterium Bovis BCG Latent Infection

(2017) F. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

PSGL-1: A New Player in the Immune Checkpoint Landscape

(2017) Roberto Tinoco et al.   TRENDS IN IMMUNOLOGY

Interleukin-2 reverses CD8+T cell exhaustion in clinical malignant pleural effusion of lung cancer

(2016) C. Y. Hu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

T-cell exhaustion in tuberculosis: pitfalls and prospects

(2016) Nargis Khan et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Evaluation of IL-2, IL-10, IL-17 and IP-10 as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects

(2016) Eunkyoung You et al.   TUBERCULOSIS

A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice

(2016) Xun Liu et al.   VACCINE

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis

(2016) Xun Liu et al.   Human Vaccines & Immunotherapeutics

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

(2016) Pushpa Jayaraman et al.   PLoS Pathogens

PD-1/PD-L pathway inhibits M.tb-specific CD4+ T-cell functions and phagocytosis of macrophages in active tuberculosis

(2016) Lei Shen et al.   Scientific Reports

The beneficial effects of adjunctive recombinant human interleukin-2 for multidrug resistant tuberculosis

(2015) Hong Shen et al.   Archives of Medical Science

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

CD1 and mycobacterial lipids activate human T cells

(2015) Ildiko Van Rhijn et al.   IMMUNOLOGICAL REVIEWS

T cell exhaustion during persistent viral infections

(2015) Shannon M. Kahan et al.   VIROLOGY

CD4+T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4+T cells during chronic infection

(2013) Courtney Dow et al.   IMMUNOLOGY

Differentiation of Antigen-Specific T Cells with Limited Functional Capacity during Mycobacterium tuberculosis Infection

(2013) Yun Hee Jeong et al.   INFECTION AND IMMUNITY

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

(2013) Erin E. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis

(2012) YongRong Zhang et al.   Science China-Life Sciences

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4–HspX

(2011) Hongxia Niu et al.   VACCINE

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immunology of tuberculosis: From bench to bedside

(2010) Keertan DHEDA et al.   RESPIROLOGY

The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

(2009) Alison Crawford et al.   CURRENT OPINION IN IMMUNOLOGY

PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients

(2009) J. Fourcade et al.   JOURNAL OF IMMUNOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Fusion protein Ag85B-MPT64190–198-Mtb8.4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium tuberculosis in mice

(2009) Yu Luo et al.   VACCINE

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA