标题
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
作者
关键词
T cells, Mycobacterium tuberculosis, Cytotoxic T cells, T cell receptors, CD coreceptors, Cytokines, Tuberculosis, Cell-mediated immunity
出版物
PLoS Pathogens
Volume 12, Issue 3, Pages e1005490
出版商
Public Library of Science (PLoS)
发表日期
2016-03-12
DOI
10.1371/journal.ppat.1005490
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
- (2014) Alison Crawford et al. IMMUNITY
- Cutting Edge: Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma-Homing CD4 T Cells
- (2014) S. Sakai et al. JOURNAL OF IMMUNOLOGY
- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
- (2014) Yu-Hwa Huang et al. NATURE
- Intravascular staining for discrimination of vascular and tissue leukocytes
- (2014) Kristin G Anderson et al. Nature Protocols
- TGF-β Signaling Initiated in Dendritic Cells Instructs Suppressive Effects on Th17 Differentiation at the Site of Neuroinflammation
- (2014) Suzanne Speck et al. PLoS One
- PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-Specific CD8+ T Cells Induced by Melanoma Vaccines
- (2013) J. Fourcade et al. CANCER RESEARCH
- IL-1 Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation
- (2013) P. Jayaraman et al. JOURNAL OF IMMUNOLOGY
- A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
- (2013) Taku Okazaki et al. NATURE IMMUNOLOGY
- Clonal Expansions of CD8+ T Cells with IL-10 Secreting Capacity Occur during Chronic Mycobacterium tuberculosis Infection
- (2013) Joshua C. Cyktor et al. PLoS One
- Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8+ T Cells and Efficiently Reduces Chronic Retroviral Loads
- (2013) Kirsten K. Dietze et al. PLoS Pathogens
- TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
- (2013) Kaori Sakuishi et al. OncoImmunology
- Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
- (2012) R. G. Veenstra et al. BLOOD
- Risk of Progression to Active Tuberculosis Following Reinfection With Mycobacterium tuberculosis
- (2012) Jason R. Andrews et al. CLINICAL INFECTIOUS DISEASES
- Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
- (2012) Suzanne L Topalian et al. CURRENT OPINION IN IMMUNOLOGY
- Blockade of Tim-3 signaling restores the virus-specific CD8+T-cell response in patients with chronic hepatitis B
- (2012) Wei Wu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
- (2012) Hang Li et al. HEPATOLOGY
- Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
- (2012) Travis A. Doering et al. IMMUNITY
- Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
- (2012) Shipra Gupta et al. JOURNAL OF CLINICAL INVESTIGATION
- The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut
- (2012) S. Kawamoto et al. SCIENCE
- Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions
- (2012) Yueqin Qiu et al. PLoS Pathogens
- Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
- (2011) Q. Zhou et al. BLOOD
- Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis
- (2011) Xinjing Wang et al. JOURNAL OF INFECTION
- Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes
- (2011) Ying Zhang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The role of IL-10 in immune regulation during M. tuberculosis infection
- (2011) P S Redford et al. Mucosal Immunology
- Tim3 binding to galectin-9 stimulates antimicrobial immunity
- (2010) Pushpa Jayaraman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients
- (2010) Julien Fourcade et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition
- (2010) D. L. Barber et al. JOURNAL OF IMMUNOLOGY
- Mycobacterium tuberculosis Directs Immunofocusing of CD8+ T Cell Responses Despite Vaccination
- (2010) J. S. Woodworth et al. JOURNAL OF IMMUNOLOGY
- Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
- (2010) H.-T. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis
- (2010) E. Lazar-Molnar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts
- (2009) Alexander V. Pichugin et al. AMERICAN JOURNAL OF PATHOLOGY
- Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
- (2009) L. Golden-Mason et al. JOURNAL OF VIROLOGY
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
- (2008) R. Brad Jones et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started