The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling inCaenorhabditis elegans

(2015) Mihwa Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity

(2015) Peter M. Douglas et al.   Cell Reports

The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

(2014) Adam L. Knight et al.   Cell Metabolism

A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication

(2014) W. L. Hung et al.   DEVELOPMENT

Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest

(2014) Yutao Chen et al.   DEVELOPMENTAL BIOLOGY

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

(2014) Michael M. Mueller et al.   NATURE CELL BIOLOGY

Insights from the worm: The C. elegans model for innate immunity

(2014) Maria A. Ermolaeva et al.   SEMINARS IN IMMUNOLOGY

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

(2014) Shanshan Pang et al.   Nature Communications

An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

(2014) Diana Andrea Fernandes de Abreu et al.   PLoS Genetics

Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis

(2013) Jia Li et al.   ACTA PHARMACOLOGICA SINICA

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways inC. elegans

(2013) Keunhee Seo et al.   AGING CELL

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

Complex expression dynamics and robustness in C. elegans insulin networks

(2013) A. D. Ritter et al.   GENOME RESEARCH

Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans

(2013) Sarah G Leinwand et al.   NATURE NEUROSCIENCE

Two Insulin-like Peptides Antagonistically Regulate Aversive Olfactory Learning in C. elegans

(2013) Zhunan Chen et al.   NEURON

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

(2013) Trisha A. Staab et al.   PLoS Genetics

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

(2012) Wei-Chung Chiang et al.   CELL

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation

(2012) A. Garelli et al.   SCIENCE

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

(2012) Wei-Chung Chiang et al.   PLoS Genetics

A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans

(2012) Diána Papp et al.   PLoS Pathogens

Hypertonic stress induces rapid and widespread protein damage in C. elegans

(2011) Kris Burkewitz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Specific insulin-like peptides encode sensory information to regulate distinct developmental processes

(2011) A. Cornils et al.   DEVELOPMENT

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

(2011) Xuan Li et al.   PLoS Genetics

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

(2010) Gawain McColl et al.   Cell Metabolism

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

(2010) Hena Alam et al.   Cell Metabolism

Insulin signaling promotes germline proliferation in C. elegans

(2010) D. Michaelson et al.   DEVELOPMENT

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1

(2009) Sang-Kyu Park et al.   AGING CELL

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States

(2009) Maija Slaidina et al.   DEVELOPMENTAL CELL

A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

(2009) Naoki Okamoto et al.   DEVELOPMENTAL CELL

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

(2009) K. P. Choe et al.   MOLECULAR AND CELLULAR BIOLOGY

Divergent Mechanisms Controlling Hypoxic Sensitivity and Lifespan by the DAF-2/Insulin/IGF-Receptor Pathway

(2009) Meghann E. Mabon et al.   PLoS One

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

14-3-3ɛ antagonizes FoxO to control growth, apoptosis and longevity inDrosophila

(2008) Mette Damgaard Nielsen et al.   AGING CELL

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity inC. elegans

(2008) Eric A. Evans et al.   AGING CELL

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

(2008) Katherine A. Steinkraus et al.   AGING CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

(2008) Kyu-Sun Lee et al.   NATURE CELL BIOLOGY

Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling

(2008) Trupti Kawli et al.   NATURE IMMUNOLOGY

Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs

(2008) Susan Broughton et al.   PLoS One

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator

(2008) Ji Li et al.   PLOS BIOLOGY

Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans

(2008) Eric A. Evans et al.   PLoS Pathogens

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL