Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

(2019) Nicolas P Andrews et al.   eLife

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

(2019) Katja Burk et al.   ACTA NEUROPATHOLOGICA

The Role of LRRK2 in Neurodegeneration of Parkinson Disease

(2018) Qin Rui et al.   Current Neuropharmacology

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis

(2018) Yingying Zhang et al.   GENES & DEVELOPMENT

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

(2018) Yingxiao Shi et al.   NATURE MEDICINE

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors

(2018) Anand Venkataraman et al.   NATURE METHODS

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

(2018) Maneka Chitiprolu et al.   Nature Communications

Antibody validation: a view from the mountains

(2018) Michael J. Taussig et al.   New Biotechnology

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

(2018) Petra Frick et al.   Acta Neuropathologica Communications

A high-throughput pipeline for validation of antibodies

(2018) Krzysztof Sikorski et al.   NATURE METHODS

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

(2016) Chantal Sellier et al.   EMBO JOURNAL

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

(2016) Joseph Amick et al.   MOLECULAR BIOLOGY OF THE CELL

A proposal for validation of antibodies

(2016) Mathias Uhlen et al.   NATURE METHODS

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

(2016) Jie Jiang et al.   NEURON

A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes

(2016) Hong Na et al.   RNA

C9orf72 is required for proper macrophage and microglial function in mice

(2016) J. G. ORourke et al.   SCIENCE

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

(2016) Aaron Burberry et al.   Science Translational Medicine

Erratum: C9ORF72 expression and cellular localization over mouse development

(2016) Rachel A. K. Atkinson et al.   Acta Neuropathologica Communications

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice

(2016) Amanda Atanasio et al.   Scientific Reports

A High Through-put Platform for Recombinant Antibodies to Folded Proteins

(2015) Michael Hornsby et al.   MOLECULAR & CELLULAR PROTEOMICS

Reproducibility: Standardize antibodies used in research

(2015) Andrew Bradbury et al.   NATURE

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

(2015) Edyta Marcon et al.   NATURE METHODS

Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines

(2015) Mingcong Wang et al.   PROTEOMICS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Dissecting Antibodies with Regards to Linear and Conformational Epitopes

(2015) Björn Forsström et al.   PLoS One

Frontotemporal dementia: a bridge between dementia and neuromuscular disease

(2014) Adeline S.L. Ng et al.   Annals of the New York Academy of Sciences

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

(2014) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

Bone Marrow-derived Macrophage Production

(2013) Virginie Trouplin et al.   Jove-Journal of Visualized Experiments

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Small GTPase Rab12 Regulates Constitutive Degradation of Transferrin Receptor

(2011) Takahide Matsui et al.   TRAFFIC

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages

(2009) D. Liebl et al.   JOURNAL OF CELL SCIENCE

A single fixation protocol for proteome-wide immunofluorescence localization studies

(2009) Charlotte Stadler et al.   Journal of Proteomics