期刊
CURRENT NEUROPHARMACOLOGY
卷 16, 期 9, 页码 1348-1357出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X16666180222165418
关键词
Leucine-rich repeat kinase 2; MAPK; alpha-synuclein; neurodegeneration; neuroinflammation; microglia; Parkinson's disease
The leucine-rich repeat kinase 2 (LRRK2) gene and a-synuclein gene (SNCA) are the key influencing factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of alpha-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of alpha-synuclein is one of the main stimulants of microglial activation. Microglia are macrophages that reside in the brain, and activation of microglia is believed to contribute to neuroinflammation and neuronal death in PD. Therefore, clarifying the complex relationship among LRRK2, alpha-synuclein and microglials could offer targeted clinical therapies for PD. Here, we provide an updated review focused on the discussion of the evidence supporting some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD.
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