Article
Biochemistry & Molecular Biology
Myung Jin Lee, Hyang Hwa Ryu, Jae Won Hwang, Jung Ryul Kim, Eui-Sic Cho, Jin Kyeong Choi, Young Jae Moon
Summary: Periodontitis is an inflammatory disease that causes destruction of periodontal tissue. Sirt6, a protein, has been found to suppress inflammation and bone resorption, but its role in periodontitis was unclear. By studying mice with Sirt6 overexpression and using a Sirt6 activator called MDL801, the researchers found that Sirt6 activation prevented bone loss in periodontitis. This suggests that a Sirt6 activator could be a potential therapeutic approach for treating periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Hidefumi Sako, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Hidetaka Ideguchi, Saki Yoshimura-Nakagawa, Kyosuke Sakaida, Chiaki Nagata-Kamei, Hiroya Kobayashi, Satoki Ishii, Mitsuaki Ono, Soichiro Ibaragi, Tadashi Yamamoto, Seiji Suga, Shogo Takashiba
Summary: The current approach to treating periodontal disease focuses on removing the source of infection, but does not address the host inflammatory response that leads to tissue destruction. This study investigated the effects of synthetic (+)-terrein on inflammatory bone resorption in a mouse model of periodontitis. The results showed that (+)-terrein can suppress alveolar bone resorption by inhibiting TNF-a production and osteoclast differentiation. Therefore, (+)-terrein has potential clinical effects in treating inflammatory bone resorption, including periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Emilio A. Cafferata, Sebastian Castro-Saavedra, Gonzalo Fuentes-Barros, Samanta Melgar-Rodriguez, Felipe Rivera, Paola Carvajal, Marcela Hernandez, Bastian Cortes, Cristian Cortez, Bruce K. Cassels, Rolando Vernal
Summary: Boldine effectively inhibits alveolar bone resorption during periodontitis by modulating the Th17/Treg imbalance, reducing osteoclast numbers and the RANKL/OPG ratio, and improving T-cell homeostasis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zijiao Zhang, Juhan Song, Seung-Hee Kwon, Zhao Wang, Suk-Gyun Park, Xianyu Piao, Je-Hwang Ryu, Nacksung Kim, Ok-Su Kim, Sun-Hun Kim, Jeong-Tae Koh
Summary: This study found that pirfenidone (PFD) can significantly inhibit alveolar bone loss caused by ligature in mice. PFD may be a promising candidate for controlling periodontitis by suppressing osteoclastogenesis and inflammatory cytokine production through inhibiting the NF-kappa B signal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenmin Zeng, Guojing Liu, Qingxian Luan, Chunyu Yang, Shiyi Li, Xiaoqian Yu, Li Su
Summary: B-cell deficiency exacerbates inflammation and alveolar bone loss in ligature-induced experimental periodontitis in mice, suggesting a role for B cells in the initiation of periodontitis. This is associated with increased osteoclast activity, upregulated RANKL expression, and a shift in gingiva cytokine expression profiles to Th1 and Th17. Additionally, a reduced CD4(+)/CD8(+) T cell ratio was observed in the B cell-deficient mice.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Yuyi Chen, Qiudong Yang, Chunhua Lv, Yue Chen, Wenhua Zhao, Wenlei Li, Hongyu Chen, Hua Wang, Wen Sun, Hua Yuan
Summary: The study demonstrates that NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. MCC950 can inhibit the differentiation of osteoclast precursors and reduce the number of Lysm-Cre(+) osteoclast precursors in periodontitis, leading to significant suppression of alveolar bone loss.
CELL PROLIFERATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yuni Lee, Bo Hyun Jung, Ki-Yeon Yoo, Hye Ji Lim, Kum-Joo Shin, Jae-Kwan Lee
Summary: This study found that Lactobacillus fermentum BELF11 can inhibit alveolar bone loss and the progression of periodontitis by regulating the production of pro-inflammatory cytokines. This suggests that Lactobacillus fermentum BELF11 may be a potential adjunctive therapy in periodontal treatment.
Article
Dentistry, Oral Surgery & Medicine
Ying Chen, Yang Hu
Summary: The study demonstrates that PPARα agonist fenofibrate can effectively inhibit inflammatory responses and reduce bone loss in periodontitis. This anti-inflammatory treatment shows promising potential in combating periodontal diseases.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yuka Nishida, Katsumitsu Shimada, Kanji Horibe, Kousuke Seki, Yoshinori Murai, Chiharu Sogawa, Satoshi Murakami, Hiroaki Nakamura, Yuji Masuda, Norio Sogawa
Summary: Chlorogenic acid (CGA), a polyphenol found in coffee beans, vegetables, and fruits, has been shown to have antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effects of CGA against alveolar bone loss caused by experimental periodontitis using a ligature-induced model.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Burak Dogan, Esra Sinem Kemer Dogan, Ozlem Ozmen, Ozlem Fentoglu, Fatma Yesim Kirzioglu, Mustafa Calapoglu
Summary: Omega-3 and probiotics, when combined, showed a synergistic effect on host modulation in improving periodontal health. The prophylactic administration of omega-3 and probiotic combination reduced alveolar bone loss and improved serum IL1 beta, IL6, and IL10 levels more than their single use.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Immunology
Izabel C. V. de Oliveira, Leonardo V. Galvao-Moreira, Juliana L. Vilela, Murillo Duarte-Silva, Lucas D. Aguiar-da-Silva, Cesar A. A. Pereira, Domingos M. S. Pereira, Aruana J. M. C. R. Pinheiro, Lidio G. Lima-Neto, Elizabeth S. Fernandes, Cristina R. B. Cardoso, Luciana S. Branco-de-Almeida
Summary: Cinnamaldehyde treatment reduces periodontal bone loss, attenuates inflammatory mediators, and regulates human PBMC responses, suggesting its potential therapeutic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Fengzhen Lei, Mujia Li, Tingting Lin, Hong Zhou, Fei Wang, Xiaoxia Su
Summary: Exosomes secreted by healthy periodontal ligament stem cells (PDLSCs) promote osteogenic differentiation of PDLSCs derived from periodontitis tissue. Treatment with exosomes can accelerate bone formation in rat models of periodontitis. Mechanistically, exosomes suppress over-activation of the canonical Wnt signaling pathway to recover the osteogenic differentiation capacity of inflammatory PDLSCs. These findings suggest that MSC-derived exosomes are an effective and practical cell-free therapeutic for the treatment of periodontitis.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Urara Tanaka, Shunichi Kajioka, Livia S. Finoti, Daniela B. Palioto, Denis F. Kinane, Manjunatha R. Benakanakere
Summary: This study demonstrated that Decitabine inhibits bone loss and osteoclast differentiation in experimental periodontitis, while upregulating anti-inflammatory cytokines through a KLF2-dependent mechanism. This suggests that DNA methyltransferase inhibitors could be a potential novel therapy for periodontitis.
Article
Oncology
Aixiu Gong, Yining Liu, Fangrong Xu, Yiting Chu, Jun Wu, David Goltzman, Dengshun Miao
Summary: This study assessed the effects of 1,25(OH)(2)D deficiency and supplementation on alveolar bone loss and gingival inflammation induced by ligature-induced periodontitis. The results showed that 1,25(OH)(2)D deficiency enhanced the severity of alveolar bone loss and gingival inflammation, while supplementation with 1,25(OH)(2)D-3 alleviated these symptoms, although not completely.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Physical
Aladdin M. Srour, Hoda H. Fahmy, Mai A. Khater, Eman S. Zarie, Sherif S. Mohamed, Mohamed F. Abdelhameed
Summary: A variety of trisubstituted pyrazole derivatives were synthesized and evaluated for their anti-inflammatory, analgesic, antipyretic, and ulcerogenic properties. Compounds 3a, 3b, 6, 8, and 11 showed promising anti-inflammatory and analgesic effects, with compound 8 exhibiting the best results and mutual inhibitory effects on tested enzymes. Molecular docking study revealed that compound 8 had the highest binding interaction scores with COX-2 and TNF-alpha, supporting its potential as an anti-inflammatory drug.
JOURNAL OF MOLECULAR STRUCTURE
(2022)