Article
Materials Science, Multidisciplinary
Jinggong Liu, Wenying Li, Yongpeng Lin, Yongjun Peng, Meixiao Zhan, Haoqiang Lai, Yanzhou Chang, Yongjin Li, Ka-hing Wong, Bolai Chen, Tianfeng Chen
Summary: A dual-targeted nanotherapeutics (MP3/ACPP/AE105@NPs) with uPAR targeting and tumor microenvironment-responsive ability was developed, which improved the therapeutic efficacy and reduced toxic side effects in the treatment of breast cancer. This nanotherapeutics also stimulated immunotherapeutic response, activating cytotoxic T cells, enhancing dendritic cells maturation, and inhibiting the proliferation of tumor-associated M2 macrophages.
NPG ASIA MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Qingxin Mu, Guanyou Lin, Mike Jeon, Hui Wang, Fei-Chien Chang, Richard A. Revia, John Yu, Miqin Zhang
Summary: This study presents a multifunctional nanoparticle formulation targeting TNBC cells and dendritic cells, inducing tumor apoptosis through multiple mechanisms and significantly inhibiting tumor growth and metastasis while extending survival in a drug-resistant mouse model of TNBC. The promising platform may substantially improve therapeutic efficacy for treating metastatic TNBC.
Article
Biophysics
Qingran Guan, Yinglan Li, Huaizhen Zhang, Sisi Liu, Zhuang Ding, Zhiping Fan, Qingpeng Wang, Zhengping Wang, Jun Han, Min Liu, Yanna Zhao
Summary: Novel laser-responsive multi-functional nanoparticles (NPs-Lip@PTX/CyA/Ce6) were developed using bovine serum albumins (BSA) as the base material, simultaneously carrying chemotherapeutic drug paclitaxel (PTX) and P-gp inhibitor cyclosporin A (CyA) as the core, and Tf-modified liposomal bilayer loaded with photosensitizer Chlorin e6 (Ce6) as the shell. The NPs-Lip@PTX/CyA/Ce6 exhibited a core-shell structure with good stability in aqueous solution. Upon laser irradiation, the NPs-Lip@PTX/CyA/Ce6 showed laser-responsive release profiles, enabling efficient combinatorial chemophotodynamic therapy and reversal of drug resistance. The NPs-Lip@PTX/CyA/Ce6 demonstrated excellent intracellular ROS productivity and anti-cancer therapy effect without systemic toxicity. In conclusion, this nano-drug delivery system holds promise for clinical applications in compositional chemophotodynamic therapy synergistically.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Ying Long, Jialong Fan, Naduo Zhou, Jiahao Liang, Chang Xiao, Wei Wang, Bin Liu
Summary: This study presents a novel strategy for the treatment of triple-negative breast cancer (TNBC) using nanomaterial-based multimodal nanomedicine. The researchers developed a new nanomedicine by loading Cinobufagin (CS-1) into Prussian blue nanoparticles (PB NPs), which could release CS-1 in a photothermal-controlled manner. The nanomedicine also utilized hybrid membrane (HM) camouflage to enhance immune escape and tumor-targeting ability. In vitro and in vivo experiments demonstrated that this strategy effectively inhibited tumor growth and promoted dendritic cell (DCs) maturation.
Article
Pharmacology & Pharmacy
Yun Yang, Danrong Hu, Yi Lu, Bingyang Chu, Xinlong He, Yu Chen, Yao Xiao, Chengli Yang, Kai Zhou, Liping Yuan, Zhiyong Qian
Summary: A multifunctional nanoparticle system has been developed to deliver chemotherapy drugs synchronously to breast cancer tumor sites, showing promising synergistic effects.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu, Wenting Li, Wei Hong
Summary: Nanoscale structures have been developed for various functions in cancer therapy, including diagnosis, biomedical visualization, tissue regeneration, and drug delivery. By using biocompatible chitosan oligosaccharides and gold nanorods, a drug delivery system was designed that effectively delivered drugs to tumor sites and selectively targeted cancer cells. The system also had drug release capability and magnetic resonance imaging functionality, showing promising outcomes for tumor diagnosis and treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Yanjuan Huang, Zilin Guan, Xiuling Dai, Yifeng Shen, Qin Wei, Lingling Ren, Jingwen Jiang, Zhanghong Xiao, Yali Jiang, Di Liu, Zeqian Huang, Xiaoyu Xu, Yong Luo, Chunshun Zhao
Summary: Engineered macrophages carrying nanomedicine were designed for enhanced chemo/photo/immunotherapy of primary and bone metastatic tumors. This approach showed efficient tumor targeting and therapeutic release triggered by near-infrared light, leading to improved overall survival with limited systemic toxicity.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Barbara Carrese, Chiara Cavallini, Gennaro Sanita, Paolo Armanetti, Brigida Silvestri, Gaetano Cali, Giulio Pota, Giuseppina Luciani, Luca Menichetti, Annalisa Lamberti
Summary: Hybrid nanomaterials with silver seeds show promising results for molecular imaging and therapeutic applications, especially in enhancing cytotoxic activity at lower drug doses. This integrated photothermal chemotherapy approach has the potential to reduce adverse side effects of chemotherapy in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jingjing Xu, Xiaojing Yang, Xianjiao Tang, Mei-Xia Zhao
Summary: This study introduces pH-sensitive Cy7-PEG-CA-DOX micelles for controlled drug release, tumor imaging, and synergistic cancer therapy. The micelles effectively released the anticancer drug doxorubicin in tumor cells and exhibited optimal tumor imaging properties. They also facilitated the favorable anti-breast cancer effects of photothermal therapy and chemotherapy in vivo.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Biochemical Research Methods
Ruiyi Dai, Xiangrong Peng, Bi Lin, Danyang Xu, Ruichan Lv
Summary: A NIR II luminescence imaging and enhanced chemo-/photothermal therapy system for breast cancer and lymph node tracing has been proposed, utilizing CuS-DOX-Nd/FA NPs under single 808 nm irradiation. The system combines imaging and treatment capabilities to target tumors with high precision and efficiency for improved prognosis.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Zhihong Zeng, Zhou Wang, Simin Chen, Chang Xiao, Minzhuo Liu, Jie Zhang, Jialong Fan, Yanzhong Zhao, Bin Liu
Summary: In this study, a novel combination therapy was developed for triple-negative breast cancer (TNBC) using nanoparticles to generate oxygen and inhibit tumor growth and metastasis. The results demonstrated that this strategy significantly inhibited tumor growth and distant metastasis in vivo, providing a new approach for the treatment of malignant tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Oncology
Valentina Rapozzi, Francesca Moret, Luca Menilli, Andrea Guerrini, Daniele Tedesco, Marina Naldi, Manuela Bartolini, Mariachiara Gani, Sonia Zorzet, Marta Columbaro, Celeste Milani, Cecilia Martini, Claudia Ferroni, Greta Varchi
Summary: In this study, bioresponsive nanoparticles were developed for the combined photo- and chemo-treatment of breast cancer. The nanoparticles showed sustained and controlled drug release under the unique conditions of the tumor environment. In vitro and in vivo experiments demonstrated the potential of these nanoparticles in reducing tumor mass and curbing lung metastases growth.
Article
Pharmacology & Pharmacy
Wenfeng Jia, Rui Liu, Yushan Wang, Chuan Hu, Wenqi Yu, Yang Zhou, Ling Wang, Mengjiao Zhang, Huile Gao, Xiang Gao
Summary: In this study, a dual-response shape transformation and charge reversal strategy was designed to improve the anti-tumor effect using chemo-photodynamic therapy. The tumor microenvironment-responsive nanoparticles were constructed to achieve charge reversal, size reduction, and enhanced tumor penetration, and induce tumor cell death by releasing chemotherapy drugs through the photosensitizer.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Xiaolan Feng, Chen Wu, Wenhao Yang, Jiayi Wu, Pan Wang
Summary: Due to its noninvasive nature and high tissue penetrating capabilities, ultrasound-driven sonodynamic treatment (SDT) has broad application possibilities in various diseases. However, the inefficient buildup of sonosensitizers in the tumor site significantly impairs the effectiveness of SDT. This study proposes a deep-penetrating sonochemistry nanoplatform for controlled release of reactive oxygen species and drugs, leading to improved chemotherapeutic effectiveness and SDT efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Kittiphot Songkaitiwong, Kitsakorn Locharoenrat
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Pawin Raksrithong, Kitsakorn Locharoenrat
Article
Biochemical Research Methods
Suwaphit Phoemphoonthanyakit, Panpailin Seeharaj, Pattareeya Damrongsak, Kitsakorn Locharoenrat
JOURNAL OF SPECTROSCOPY
(2019)
Article
Engineering, Biomedical
Suttirak Pairoj, Pattareeya Damrongsak, Badin Damrongsak, Natini Jinawath, Rossukon Kaewkhaw, Tanaporn Leelawattananon, Chinnapat Ruttanasirawit, Kitsakorn Locharoenrat
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2019)
Article
Dentistry, Oral Surgery & Medicine
Nattha Lertsukprasert, Kitsakorn Locharoenrat
Article
Biotechnology & Applied Microbiology
Suttirak Pairoj, Pattareeya Damrongsak, Badin Damrongsak, Natini Jinawath, Rossukon Kaewkhaw, Chinnapat Ruttanasirawit, Tanaporn Leelawattananon, Kitsakorn Locharoenrat
Summary: This study aimed to enhance the specific interactions between multiple chemo drug candidates and human cancer cell lines by immobilizing them on ZnO nanoparticles. Among the formulated chemo drugs, the CP-DOX-ZnO complex showed high sensitivity towards breast adenocarcinoma cells with high loading capacity and efficiency. The results suggest that the endocytosis of Carboplatin-DOX-ZnO by cancer cells leads to selective internalization and induced acute apoptosis, resulting in inhibition of the growth signal of target cancer cells.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Kittituspong Wichachang, Kitsakorn Locharoenrat
Summary: Fluorescence emitted by Zn(II)-protoporphyrin-9 can be used for diagnosing caries enamel lesions, with maximum fluorescence intensity reached when Zn(II) is at 0.0256 mu M. The fluorescence image has high contrast, fluorescence quantum efficiency, and photostability.
OPTICAL MATERIALS EXPRESS
(2021)
Article
Biotechnology & Applied Microbiology
Thanachai Changcharoen, Thidsanu Apiphatnaphakul, Wasupon Watjanavarreerat, Kitsakorn Locharoenrat
Summary: This study investigates the optical functions of butterfly wing scales and their potential as a photonic sensor. It confirms the presence of metal oxide nanoparticles mixed with nicotine using optical microscopy and spectroscopy. The results show that the absorption intensities of ZnO and TiO2 mixed with nicotine on Danaus genutia are significantly enhanced. The study also suggests that this sensor could be a simple and effective method for the rapid test of ZnO content.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pattarapol Sittisart, Kitsakorn Locharoenrat
Summary: This study aimed to enhance the specific interactions between human hepatocellular carcinoma cell lines (HepG-2) by preparing and investigating the fluorescence emission properties of the Ag-Au-ICG complex. The complex was prepared via physical adsorption and evaluated for fluorescence spectra. The addition of an optimized dosage of Ag-Au-ICG to HepG-2 resulted in maximum fluorescence signal intensity and enhanced contrast fluorescence. The complex showed low cytotoxicity, making it a potential fluorescence enhancer for liver cancer imaging.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wannisa Khamaikawin, Kitsakorn Locharoenrat
Summary: This study evaluated the anti-tumor effect of gold nanoparticles as a delivery vehicle for a triple chemotherapy drug formulation. The gold nano-carrier effectively loaded docetaxel, cisplatin, and 5-fluorouracil, and exhibited controlled drug release. The triple chemotherapy drug formulation demonstrated superior cytotoxicity in oral cavity cancer cells compared to plain docetaxel-cisplatin-fluorouracil.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Wasupon Watjanavarreerat, Liviu Steier, Kitsakorn Locharoenrat
Summary: This study investigated the metal-binding effect of fluoride in commercial toothpaste gels and proposed an alternative method for fluoride analysis. The results provide valuable information for dentists to prevent enamel demineralization.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Kittiphot Songkaitiwong, Kitsakorn Locharoenrat
KUWAIT JOURNAL OF SCIENCE
(2020)
Article
Optics
Pattareeya Damrongsak, Bhanupol Klongratog, Sirichai Hoomsuk, Kitsakorn Locharoenrat
UKRAINIAN JOURNAL OF PHYSICAL OPTICS
(2019)
Article
Optics
Kitsakorn Locharoenrat, Pattareeya Damrongsak
UKRAINIAN JOURNAL OF PHYSICAL OPTICS
(2019)