Review
Microbiology
Zahra Dossaji, Adam Khattak, Kyaw Min Tun, Mark Hsu, Kavita Batra, Annie S. S. Hong
Summary: There is a high prevalence of gastrointestinal-related symptoms among children with autism spectrum disorder (ASD), and these symptoms are associated with the severity of behavioral symptoms. Fecal microbiota transplantation (FMT) is a potential therapeutic strategy for addressing gut microbiome dysregulation in pediatric patients with ASD. A systematic review found that FMT led to significant improvements in both behavioral and gastrointestinal symptoms in these patients. These findings suggest that FMT holds promise as an intervention for treating pediatric patients with autism.
Review
Microbiology
Mihaela Adela Iancu, Monica Profir, Oana Alexandra Rosu, Ruxandra Florentina Ionescu, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: The gut microbiota plays a crucial role in gut health and immune metabolism. Probiotics have the potential to modulate the gut microbiome, strengthen the intestinal barrier, and regulate the immune system, thus offering benefits in treating diarrhea and constipation.
Article
Immunology
Ning Li, Hongyan Chen, Yi Cheng, Fenghua Xu, Guangcong Ruan, Senhong Ying, Wen Tang, Lu Chen, Minjia Chen, LinLing Lv, Yi Ping, Dongfeng Chen, Yanling Wei
Summary: This study found that fecal microbiota transplantation (FMT) can improve gastrointestinal symptoms and behavioral symptoms in children with autism spectrum disorder (ASD) without causing severe complications. FMT may be a promising therapeutic strategy to improve the symptoms of patients with ASD by altering gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Angel F. Valenzuela-Zamora, David G. Ramirez-Valenzuela, Arnulfo Ramos-Jimenez
Summary: This article provides a narrative review of the literature on food selectivity (FS) in children with autism spectrum disorders (ASD) from the last 15 years, and examines its relationship with gastrointestinal disorders (GID) related to alterations in the intestinal microbiota in children with ASD. The study found that sensory aversion in ASD leads to the elimination of certain foods, which can disrupt the gut microbiota and potentially trigger GID. It was also observed that FS may be a consequence of prior GID. The article emphasizes the need for more rigorous studies in selecting children with ASD, uniform criteria for evaluating GID, and proper classification of FS in children with ASD.
Article
Multidisciplinary Sciences
Jinyuan Yan, Chen Liao, Bradford P. Taylor, Emily Fontana, Luigi A. Amoretti, Roberta J. Wright, Eric R. Littmann, Anqi Dai, Nicholas Waters, Jonathan U. Peled, Ying Taur, Miguel-Angel Perales, Benjamin A. Siranosian, Ami S. Bhatt, Marcel R. M. van den Brink, Eric G. Pamer, Jonas Schluter, Joao B. Xavier
Summary: In this study, we used shotgun metagenomics to analyze the functional level of the gut microbiome in hospitalized patients receiving hematopoietic cell transplants. We compiled a dataset of 395 samples and provided accession numbers for easy analysis in a public repository.
Article
Behavioral Sciences
Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M. Persico
Summary: The study shows that gut mobilization significantly reduces symptoms such as hyperactivity, anxiety, irritability, and repetitive behaviors in chronically constipated autistic children. While urinary p-cresol levels varied, they were not significantly correlated with changes in behavioral parameters.
Article
Biotechnology & Applied Microbiology
Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Summary: Vancomycin is the preferred treatment for CDI but has a high recurrence rate. FMT has emerged as a successful treatment for recurrent CDI. Our study suggests that FMT can better restore gut microbiota and metabolites, promoting the recovery of colonization resistance in mice compared to vancomycin.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Will Takakura, Mark Pimentel, Satish Rao, Maria Jesus Villanueva-Millan, Christine Chang, Walter Morales, Maritza Sanchez, John Torosyan, Mohamad Rashid, Ava Hosseini, Jiajing Wang, Gabriela Leite, Edward Kowalewski, Ruchi Mathur, Ali Rezaie
Summary: This study assessed the reliability of fasting single methane measurement (SMM) in diagnosing intestinal methanogen overgrowth (IMO) and monitoring treatment response. The results showed that SMM accurately diagnosed IMO, was associated with constipation, and correlated with stool M. smithii load. Additionally, SMM remained stable without treatment and decreased after antibiotic therapy.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pediatrics
Xu Gu, Zhao-Hong Chen, Shu-Cheng Zhang
Summary: This study provides an overview of the latest updates on fecal microbiota transplantation (FMT) in pediatric diseases, including mechanisms, sample preparation, delivery approaches, safety, and indications. Evidence-based clinical trials should be introduced to address the challenges of dosage, duration, initiation, and the end point of FMT treatment in pediatric diseases.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Kan Gao, Aitak Farzi, Xueqin Ke, Yunxia Yu, Cailin Chen, Su Chen, Tengfei Yu, Haifeng Wang, Yanjun Li
Summary: Depression, associated with abnormalities in 5-HT metabolism, can be improved by certain probiotics. The L. lactis strain WHH2078 demonstrated antidepressant effects in mice with induced chronic unpredictable mild stress, through enhancing 5-HT metabolism and modulating gut microbiome composition.
Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Food Science & Technology
Yanjun Tong, Qinyue Wang, Jieyu Zhang, Ruijin Yang
Summary: This study found that xylo-oligosaccharides (XOS) can alleviate diarrhea symptoms by regulating gut microbiota, reducing pro-inflammatory factors, increasing anti-inflammatory factors, and suppressing intestinal permeability in colon tissues. Dietary supplementation of XOS may be an effective choice for preventing and alleviating diarrhea.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Lei Yang, Yue Wan, Wenwen Li, Chen Liu, Hui-fang Li, Zhiling Dong, Ke Zhu, Shu Jiang, Erxin Shang, Dawei Qian, Jinao Duan
Summary: This study aimed to clarify the laxative effect of rhubarb by analyzing the metagenome and metabolome of the gut microbiota. The results showed that rhubarb improved the disorder of intestinal microbiota and fecal metabolic profiles in constipated rats. The study suggested that rhubarb's amelioration on constipation might be achieved by modulating the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Carley Rusch, Matthew Beke, Lily Tucciarone, Carmelo Nieves, Maria Ukhanova, Massimiliano S. Tagliamonte, Volker Mai, Joon Hyuk Suh, Yu Wang, Shannon Chiu, Bhavana Patel, Adolfo Ramirez-Zamora, Bobbi Langkamp-Henken
Summary: The study shows that short-term Mediterranean diet intervention is feasible in individuals with PD, leading to weight loss, improved constipation, and modifications to gut microbiota.
FRONTIERS IN NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Torsten P. M. Scheithauer, Guido J. Bakker, Maaike Winkelmeijer, Mark Davids, Max Nieuwdorp, Daniel H. van Raalte, Hilde Herrema
Summary: Intestinal immunoglobulins play a crucial role in binding bacteria in the gut and accelerating their transit time, while also preventing the interaction of immunogenic compounds with intestinal immune cells. A study on the impact of vancomycin treatment on gut microbiome composition found that the increase in Gram-negative bacteria coincided with significantly elevated levels of immunogenic bacterial components in the feces. This led to a notable increase in intestinal antibodies, particularly IgA and IgM, which acted as a defense mechanism against pathogen intrusion into systemic sites.
Article
Environmental Sciences
Reda A. Abou-Shanab, Cara M. Santelli, Michael J. Sadowsky
Summary: The study showed that certain soil bacteria can enhance the availability of arsenic in soil, thus increasing arsenic uptake by Pteris vittata plants. Specific bacterial strains significantly improved arsenic uptake by P. vittata, leading to higher bioconcentration factors and potential use in large-scale soil remediation.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2022)
Article
Geosciences, Multidisciplinary
Weibo Kong, Fuyuan Su, Qian Zhang, Satoshi Ishii, Michael J. Sadowsky, Samiran Banerjee, Mingan Shao, Liping Qiu, Xiaorong Wei
Summary: This study in the Loess Plateau of China reveals that soil erosion and deposition have significant impacts on bacterial communities and multifunctionality. Erosion reduces bacterial richness and multifunctionality, but deposition can alleviate these negative effects. The study suggests that sustainable soil management and restoration of degraded lands can benefit from understanding the interactions between erosion, deposition, bacterial communities, and soil multifunctionality.
Article
Microbiology
Sabine Hazan, Sonya Dave, Anoja W. Gunaratne, Sibasish Dolai, Robert L. Clancy, Peter A. McCullough, Thomas J. Borody
Summary: This study examined the effectiveness of a combination therapy consisting of ivermectin, doxycycline, zinc, and vitamins D and C in treating COVID-19. The results showed that all patients experienced symptom relief and improved oxygen saturation. The study suggests that this treatment approach is safe and effective for outpatient cases with moderate to severe symptoms.
FUTURE MICROBIOLOGY
(2022)
Article
Hematology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Hossam Fathi Halaweish, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: The gut microbiota of patients with AML is disrupted during induction chemotherapy, and this disruption persists even after hospital discharge. Understanding the durability of these microbiota changes is important for subsequent phases of curative therapy.
Article
Environmental Sciences
Parul Baranwal, Dae-Wook Kang, Youngwoo Seo
Summary: This study evaluated the impact of natural organic matter (NOM) on the biodegradation of MC-LR and explored the changes in NOM composition. The results demonstrated that the presence of algal organic matter (AOM) and humic substances (HS) significantly decreased the biodegradation rate of MC-LR. Additionally, fractionation and fluorescence spectroscopy analyses revealed the sequential utilization of different NOM components by bacteria and the metabolic processes involved.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Hossam Halaweish, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: Induction chemotherapy in patients with acute myeloid leukemia significantly impacts the gut microbiota, and studying this can provide new insights into the microbiota-host relationship. Combining this with circulating metabolome analysis can shed light on the microbial contribution to metabolism. Detailed sample information and links to serum metabolomics and clinical metadata are provided for comprehensive multi-omics analysis.
Letter
Microbiology
Sabine Hazan, Sonya Dave, Thomas J. Borody, Peter A. McCullough
FUTURE MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tamanna Mustajab, Moriasi Sheba Kwamboka, Da Ae Choi, Dae Wook Kang, Junho Kim, Kyu Ri Han, Yujin Han, Sorim Lee, Dajung Song, Yong-Joon Chwae
Summary: The COVID-19 pandemic has had a significant impact on people worldwide, affecting various aspects of life. Extracellular vesicles have emerged as a potential therapeutic and vaccine development tool against COVID-19, but there are obstacles to their clinical use that need to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Jenna McGowan, Monica Borucki, Hicham Omairi, Merina Varghese, Shahnaz Vellani, Sukanya Chakravarty, Shumin Fan, Srestha Chattopadhyay, Mashuk Siddiquee, James B. Thissen, Nisha Mulakken, Joseph Moon, Jeffrey Kimbrel, Amit K. Tiwari, Roger Travis Taylor, Dae-Wook Kang, Crystal Jaing, Ritu Chakravarti, Saurabh Chattopadhyay
Summary: Wastewater-based epidemiology (WBE) is an effective tool for predicting the community spread of infectious diseases, especially during the COVID-19 pandemic. Through analyzing the correlation between viral gene copies and clinical cases, as well as sequencing RNA from wastewater to identify viral mutants, WBE can be used to predict the spread of COVID-19 and the emergence of new variants of concern. Furthermore, significant changes in the microbial community of wastewater, particularly in bacterial genera belonging to the families of Lachnospiraceae and Actinomycetaceae, show a strong correlation with the presence of SARS-CoV-2. These microbial biomarkers could serve as prediction tools for future infectious disease surveillance and outbreak responses.
Article
Cardiac & Cardiovascular Systems
Melana Yuzefpolskaya, Bruno Bohn, Annamaria Ladanyi, Alexander Khoruts, Paolo C. Colombo, Ryan T. Demmer
Summary: Despite advances in therapies, heart failure (HF) remains a progressive disease associated with significant death and disability. Cardiac replacement therapies with LVAD and HT are the only treatment options for advanced HF, but complications limit their effectiveness. Systemic inflammation plays a role in HF pathophysiology, but targeting inflammation directly has not been successful.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Physiology
E. A. Carnero, C. P. Bock, Y. Liu, K. Corbin, E. Wohlers-Kariesch, K. Ruud, J. Moon, A. Marcus, R. Krajmalnik-Brown, A. Muraviev, K. L. Vodopyanov, S. R. Smith
Summary: This study introduces a new whole room indirect calorimeter methodology for quantifying methane volume released from the human body, concurrently with energy expenditure and substrate utilization assessment. The system combines an established calorimeter with off-axis integrated-cavity output spectroscopy to measure methane concentration. The method allows for the measurement of 24-hour methane volume and its proportion to human energy intake.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Pediatrics
Qiwen Cheng, Hannah Glesener, Gabriela Montenegro, Olga Torres, Ann C. Miller, Rosa Krajmalnik-Brown, Peter Rohloff, Lee E. Voth-Gaeddert
Summary: This study aims to evaluate the impact of aflatoxin B1 (AFB1) exposure on child growth and investigate the regulatory role of the gut microbiome. The study plans to observe a cohort of 185 infants aged 6-9 months for 18 months, assessing AFB1 exposure levels, markers of gut and systemic inflammation, and fecal microbiome. Additionally, the study will explore the response of the gut microbiome to varying levels of AFB1 exposure using bioreactors and analyze metabolic pathways. Ultimately, path analysis will be used to summarize the effects of AFB1 exposure and the gut microbiome on child growth.
BMJ PAEDIATRICS OPEN
(2023)
Article
Food Science & Technology
Devin A. A. Bowes, Erin M. M. Driver, Sonja Savic, Qiwen Cheng, Corrie M. M. Whisner, Rosa Krajmalnik-Brown, Rolf U. U. Halden
Summary: This study demonstrates that wastewater-based epidemiology can be used for near real-time population dietary assessments, providing a promising tool for actionable and cost-effective data collection to support public health nutrition at the population scale.
Article
Biochemistry & Molecular Biology
Yuyin Zhou, Zheting Bi, Matthew J. Hamilton, Li Zhang, Rui Su, Michael J. Sadowsky, Sabita Roy, Alexander Khoruts, Chi Chen
Summary: This study investigated the metabolic changes induced by FMT in rCDI patients through metabolomic analysis of urine samples. The results showed that the concentration of p-cresol sulfate in urine rapidly increased, making it a potential therapeutic indicator for the effectiveness of antibiotics and FMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Hao Wang, Gary W. Feyereisen, Ping Wang, Carl Rosen, Michael J. Sadowsky, Satoshi Ishii
Summary: This study investigated the effects of bioaugmentation and biostimulation on the microbiomes and nitrate removal rates of woodchip bioreactors (WBRs). The results showed that introducing denitrifying bacteria and adding acetate can enhance the nitrate removal efficiency of WBRs. Additionally, the study found that denitrifiers are unevenly distributed in WBRs.
MICROBIOLOGY SPECTRUM
(2023)
