Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

(2018) Matija Zelic et al.   JOURNAL OF CLINICAL INVESTIGATION

Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using99mTc-Duramycin During TNF-Induced SIRS

(2018) Tinneke Delvaeye et al.   JOURNAL OF NUCLEAR MEDICINE

Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases

(2018) Wei Li et al.   Scientific Reports

Therapeutic Targeting of Connexin Channels: New Views and Challenges

(2018) Tinneke Delvaeye et al.   TRENDS IN MOLECULAR MEDICINE

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

(2017) Luc Leybaert et al.   PHARMACOLOGICAL REVIEWS

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

(2016) Mélissa Bol et al.   CARDIOVASCULAR RESEARCH

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Role of connexin 43 in vascular hyperpermeability and relationship to Rock1-MLC20 pathway in septic rats

(2015) Jie Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Changes in endothelial connexin 43 expression inversely correlate with microvessel permeability and VE-cadherin expression in endotoxin-challenged lungs

(2015) Kathirvel Kandasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Diseases associated with leaky hemichannels

(2015) Mauricio A. Retamal et al.   Frontiers in Cellular Neuroscience

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

(2015) Alexander W. Lohman et al.   Nature Communications

Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

(2015) Paul R. Clark et al.   PLoS One

Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

(2014) Tom Vanden Berghe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gap Junction Protein Connexin43 Exacerbates Lung Vascular Permeability

(2014) James J. O’Donnell et al.   PLoS One

Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons

(2014) Mauricio A. Retamal et al.   Frontiers in Cellular Neuroscience

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

(2013) Nan Wang et al.   NEUROPHARMACOLOGY

Cellular and molecular regulation of vascular permeability

(2013) Lauren Goddard et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability

(2012) Kaushik Parthasarathi   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Paracrine signaling through plasma membrane hemichannels

(2012) Nan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Mechanisms of ATP release and signalling in the blood vessel wall

(2012) A. W. Lohman et al.   CARDIOVASCULAR RESEARCH

Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+Oscillations by Providing a Bimodal Ca2+-dependent Ca2+Entry Pathway

(2012) Marijke De Bock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

Intercellular Ca2+ Waves: Mechanisms and Function

(2012) Luc Leybaert et al.   PHYSIOLOGICAL REVIEWS

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

TNF-α and IL-1β increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

(2010) David J. Duncan et al.   CELL CALCIUM

Cell membrane permeabilization via connexin hemichannels in living and dying cells

(2010) Juan C. Sáez et al.   EXPERIMENTAL CELL RESEARCH

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

(2010) Raf Ponsaerts et al.   FASEB JOURNAL

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Connexin-related signaling in cell death: to live or let die?

(2009) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner

(2009) Anje Cauwels et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

(2008) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE