Article
Chemistry, Analytical
Rianne Bulsink, Kuniyil Ajith Singh Mithun, Marvin Xavierselvan, Srivalleesha Mallidi, Wiendelt Steenbergen, Kalloor Joseph Francis
Summary: The oxygen saturation imaging technology combines dual-wavelength LED array-based photoacoustic imaging, showing potential in both preclinical and clinical applications. By utilizing structural information from ultrasound images and prior knowledge of tissue optical properties, a feasible method for oxygen saturation imaging has been proposed and validated on tissue-mimicking phantoms and animals.
Article
Radiology, Nuclear Medicine & Medical Imaging
Souradip Paul, Sufayan Mulani, Mithun Kuniyil Ajith Singh, Mayanglambam Suheshkumar Singh
Summary: The image quality of LED-based photoacoustic (PA) imaging is not optimal, especially for sub-surface vascular imaging applications, due to low signal-to-noise ratio and limited imaging depth.
Article
Acoustics
James Joseph, Mithun Kuniyil Ajith Singh, Naoto Sato, Sarah E. Bohndiek
Summary: Recent advances in high power, pulsed, light emitting diodes (LEDs) have shown potential for photoacoustic imaging. This study validated the performance of a commercial dual-wavelength LED-based PAI system, showing high temporal stability in phantom studies and successful in vivo dual-wavelength imaging. LED-based excitation shows promise for future application in functional and molecular PAI.
Article
Acoustics
Mengjie Shi, Tianrui Zhao, Simeon J. West, Adrien E. Desjardins, Tom Vercauteren, Wenfeng Xia
Summary: This study proposes a deep learning framework based on U-Net to improve the visibility of clinical metallic needles in LED-based photoacoustic and ultrasound imaging. The framework combines simulated data and in vivo measurements to address the complexity of capturing ground truth for real data. The trained neural network substantially improves needle visibility in photoacoustic imaging, achieving significant improvements in terms of signal-to-noise ratio and the modified Hausdorff distance.
Article
Chemistry, Applied
Fatemeh Sharifi, Mojtaba Naderi-Boldaji, Mahdi Ghasemi-Varnamkhasti, Kamran Kheiralipour, Mohsen Ghasemi, Ali Maleki
Summary: The aim of this study was to evaluate a photoacoustic spectroscopy system with visible to short-wave near infrared (Vis-SWNIR) light sources for detecting adulterations in cow's milk. The results showed that the system was reliable and accurate, with the highest classification accuracy in detecting adulteration type and level. Further studies are suggested to generalize the findings and extend the application of the system to other liquid foods for quality evaluation.
Review
Medicine, Research & Experimental
Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Tuong Kha Vo, Nguyen-Minh-An Tran, Minh Kim Nguyen, Toi Van Vo, Giau Van Vo
Summary: Nanotechnology-based drug delivery platforms offer potential therapeutic approach for CNS disorders, but face challenges during clinical translation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Zhisheng Ji, Judun Zheng, Yanming Ma, Hongyi Lei, Weiqiang Lin, Jialin Huang, Hua Yang, Guowei Zhang, Bin Li, Bowen Shu, Xianjin Du, Jian Zhang, Hongsheng Lin, Yuhui Liao
Summary: This study develops an emergency treatment strategy for spinal cord injury (SCI) based on the selenium matrix antioxidant system, which can effectively inhibit oxidative stress-induced damage and simultaneously evaluate the severity of SCI in real time using reversible dual-photoacoustic signals (680 and 750 nm). The strategy promotes the recovery of spinal cord tissue and locomotor function in mice with SCI. It enhances the consumption of reactive oxygen species (ROS) through the Cav 1-related pathways.
Article
Chemistry, Analytical
Michalis Orfanakis, George J. Tserevelakis, Giannis Zacharakis
Summary: The article describes a compact, cost-efficient, multiwavelength PA sensing system for quantitative measurements using high-power LED sources emitting at central wavelengths of 444 and 628 nm, and a single-element ultrasonic transducer at 3.5 MHz for signal detection. It explores the performance of LEDs in pulsed mode and the dependence of PA responses on absorber's concentration and applied energy fluence in tissue-mimicking phantoms. The developed system is capable of accurate estimations with absolute deviations ranging between 0.4 and 12.3%, demonstrating potential for in-vivo multiparametric measurements of important biomarkers.
Article
Chemistry, Analytical
Yuhling Wang, De-Fu Jhang, Tsung-Sheng Chu, Chia-Hui Tsao, Chia-Hua Tsai, Chiung-Cheng Chuang, Tzong-Rong Ger, Li-Tzong Chen, Wun-Shaing Wayne Chang, Lun-De Liao
Summary: The study introduces a robust acoustic-resolution photoacoustic imaging system with adjustable optical fibers for different imaging applications, featuring a user interface. Performance of the system was validated through in vitro and in vivo experiments, demonstrating its versatility for preclinical PA imaging studies.
Article
Chemistry, Analytical
Yong Zhang, Wei Li, Xueqian Chen, Shaoqing Xiong, Yongning Bian, Lin Yuan, Xueyun Gao, Dongdong Su
Summary: Early diagnosis of hepatic inflammation is crucial for timely treatment and prevention of further liver damage. A NIRF/PA dual-modal probe (hCy-Tf-CA) has been developed for accurate early diagnosis of hepatic inflammation by integrating high sensitivity and spatial location feedback. The probe effectively detects superoxide anion fluctuation in vitro and achieves accurate in situ imaging of acute inflammatory liver injury and autoimmune hepatitis in vivo.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Physical
Songah Jeong, Su Woong Yoo, Hea Ji Kim, Jieun Park, Ji Woo Kim, Changho Lee, Hyungwoo Kim
Summary: This review discusses the current state of PAI modality, recent progress on PAI imaging with carbon-based agents, and provides a future perspective on advanced PAI systems using carbon-based agents.
Review
Chemistry, Multidisciplinary
Yiwen Zheng, Mengyao Liu, Lixin Jiang
Summary: Molecular imaging is a valuable technology in oncology for precise diagnosis and treatment. Photoacoustic imaging, a novel imaging technique, utilizes the photoacoustic effect to obtain internal tissue information. Currently, photoacoustic imaging combined with targeted photoacoustic contrast agents is widely used in tumor molecular imaging research.
FRONTIERS IN CHEMISTRY
(2022)
Article
Acoustics
Saskia Van Heumen, Jonas J. M. Riksen, Mithun Kuniyil Ajith Singh, Gijs Van Soest, Dalibor Vasilic
Summary: LED-based photoacoustic imaging (PAI) can visualize and differentiate lymphatic vessels and veins, even in the presence of dermal backflow (DBF). This technique can be used for pre-operative lymphatic vessel imaging in the planning of lymphovenous bypass surgery. Further development of the technique is needed to improve its usability in clinical settings.
Article
Chemistry, Multidisciplinary
Yajing Han, Haoyu Yi, Yujie Wang, Zheng Li, Xia Chu, Jian-Hui Jiang
Summary: This study developed an activatable photoacoustic (PA) imaging method for monitoring brain copper levels in Alzheimer's disease (AD) patients. By using nanostructured probes, the near-infrared absorption and PA pressures were increased, enabling in vivo imaging of brain copper levels. The experiments demonstrated that this method can reduce oxidative stress and protect neuronal cells.
Article
Engineering, Biomedical
Shang Gao, Yiwei Jiang, Mucheng Li, Yang Wang, Yao Shen, Matthew C. Flegal, Benjamin C. Nephew, Gregory S. Fischer, Yuxiang Liu, Loris Fichera, Haichong K. Zhang
Summary: We developed a flexible miniaturized photoacoustic imaging probe by modifying and incorporating custom-fabricated fibers into an ultrasound laparoscopic probe. The probe allows intraoperative detection of blood vessels and nerve bundles not directly visible, thus preserving these vital structures.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Neuroimaging
Jianjian Zhang, Xiao Li, Bing Zhao, Jin Zhang, Beibei Sun, Lingling Wang, Jiaqi Tian, Mahmud Mossa-Basha, Louis J. Kim, Jing Yan, Jieqing Wan, Jianrong Xu, Yan Zhou, Huilin Zhao, Chengcheng Zhu
Summary: Irregular pulsation detected by 4D-CTA is independently associated with symptomatic and ruptured intracranial aneurysms (IAs), suggesting its potential as a novel imaging feature for assessing aneurysm vulnerability.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Surgery
Jichun Shi, Wei Wei, Zhen Wang, Haobin Ren, Chenguang Jia, Lixin Dong, Zhengwei Li, Jianjian Zhang, Yu Feng, Kaixin Huang, Xiang Li, Jincao Chen
Summary: BW coated bipolar coagulation forceps provide a convenient, cost-efficient, safer, and more efficient method for hemostasis. The study demonstrates the superior performance and safety of the technique in animal experiments, indicating its potential for verification and application in human beings.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Analytical
Suya Zhang, Lulu Ning, Zhihui Song, Xinyue Zhao, Feng Guan, Xiao-Feng Yang, Jianjian Zhang
Summary: This study designs an organic nanoprobe capable of real-time imaging of ClO- in early RA. The probe exhibits high selectivity and low detection limit for ClO- levels, and is able to monitor treatment responses and efficacy in a mouse model. The research proposes a universal molecular design strategy for the detection of ClO-, which holds potential for early diagnosis and drug screening for RA.
ANALYTICAL CHEMISTRY
(2022)
Article
Hematology
Beibei Sun, Xiaoqian Ge, Xiao Li, Jianjian Zhang, Zizhou Zhao, Xiaosheng Liu, Yan Zhou, Jianrong Xu, Huilin Zhao, Jie Sun
Summary: This study evaluated the impact of diabetes on carotid plaque neovasculature as assessed by dynamic contrast-enhanced magnetic resonance imaging. The results showed that carotid plaques in patients with diabetes had higher K-trans values, indicating leaky plaque neovasculature. This leak was associated with hemoglobin A1c and may play a role in accelerated atherosclerosis progression in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Wei Wei, Qiongyi Zhao, Ziqi Wang, Wei-Siang Liau, Dean Basic, Haobin Ren, Paul R. Marshall, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Ambika Periyakaruppiah, Jichun Shi, Jianjian Zhang, John S. Mattick, Timothy R. Mercer, Robert C. Spitale, Xiang Li, Timothy W. Bredy
Summary: In this study, RNA capture-seq was used to identify a large population of lncRNAs expressed in the infralimbic prefrontal cortex of adult male mice after fear-related learning. A specific lncRNA called ADRAM was discovered, which acts as both a scaffold and a guide to regulate the expression of memory-associated genes and is required for fear extinction memory.
Article
Oncology
Weining Weng, Tao Meng, Qianqian Zhao, Yi Shen, Guoxiang Fu, Jing Shi, Yue Zhang, Zhaohui Wang, Mingqiao Wang, Rong Pan, Linjie Ma, Caiwei Chen, Lijun Wang, Biao Zhou, Hui Zhang, Junyi Pu, Jianjian Zhang, Yi Peter Hu, Guoqiang Hua, Yu Qian, Shu-Hui Liu, Wenhao Hu, Xun Meng
Summary: This study introduces a novel class of ADCs with a self-immolative T moiety for traceless conjugation and release of exatecan. These ADCs overcome resistance faced by equivalent DXd/SN-38 ADCs in low-target-expression, large, and MDR+ tumors, and show synergy with PARP/ATR inhibitor and anti-PD-1 treatment.
Article
Materials Science, Biomaterials
Tyrell J. J. Williams, Ananthakrishnan S. S. Jeevarathinam, Faraz Jivan, Victoria Baldock, Paul Kim, Michael J. J. McShane, Daniel L. L. Alge
Summary: Continuous glucose monitoring (CGM) devices can improve disease management and outcomes for diabetes patients. Chemo-optical glucose sensors using phosphorescence lifetime-based measurement embedded within hydrogels offer a promising alternative to current CGM methods. This study evaluated the suitability of Michael addition-crosslinked PEG hydrogels for encapsulating glucose-sensing microdomains compared to calcium-crosslinked alginate hydrogels.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Clinical Neurology
Elton H. L. Yeung, Keaton Piper, Jeffrey Farooq, Jianjian Zhang, Siviero Agazzi, Harry Van Loveren, Tsz Lau
Summary: This study describes the first use of a robotic arm as a safeguard device during microsurgical aneurysm clipping procedures. The robotic arm allows for better visualization of the proximal artery and safe temporary clipping in cases of intraoperative aneurysm rupture. The results demonstrate the feasibility and ease of using the robotic arm, and suggest that it may enhance the safety of microsurgical aneurysm procedures by providing on-demand control of proximal blood flow.
OPERATIVE NEUROSURGERY
(2023)
Article
Clinical Neurology
Jeffrey Farooq, Keaton Piper, Elton Yeung, Jianjian Zhang, Harry van Loveren, Siviero Agazzi, Tsz Lau
Summary: This study evaluated the complications, graft patency, and postoperative outcomes of arterial bypass for posterior circulation intracranial atherosclerotic disease. The results showed excellent postoperative outcomes, with significant improvement in symptoms and good graft patency. No major complications were observed.
OPERATIVE NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Jin Zhang, Shenghao Ding, Bing Zhao, Beibei Sun, Qinhua Guo, Yaohua Pan, Xiao Li, Lingling Wang, Jianjian Zhang, Jiaqi Tian, Yan Zhou, Jianrong Xu, Chun Yuan, Jieqing Wan, Xihai Zhao, Huilin Zhao
Summary: Using MR vessel wall imaging (MR-VWI), the morphological and compositional features of chronic internal carotid artery occlusion (CICAO) were found to predict the success of endovascular recanalization.
Article
Chemistry, Analytical
Ananthakrishnan Soundaram Jeevarathinam, Waqas Saleem, Nya Martin, Connie Hu, Michael J. McShane
Summary: A sensitive and scalable phosphorescent oxygen sensor formulation using ethyl cellulose (EC) and polystyrene (PS) nanoparticles stabilized with various surfactants was evaluated. The EC nanoparticles showed higher sensitivity and narrow size distribution compared to PS nanoparticles. The preferred formulation of EC nanoparticles protected with PF68 exhibited high oxygen sensitivity, wide phosphorescence lifetime response, and low cytotoxicity. These EC-PF68 nanoparticles were then encapsulated in alginate microspheres to create phosphorescent nanoparticles-in-microparticle (NIMs) for glucose and lactate sensing.
Article
Chemistry, Analytical
Fang Yuan, Xiaomeng He, Yurong Lu, Lulu Ning, Xinyue Zhao, Suya Zhang, Feng Guan, Yuan Guo, Jianjian Zhang
Summary: Delayed wound healing is a common complication in diabetic patients, and effective therapies for this condition are limited. In this study, researchers designed a new H2S donor called PRO-F, which can promote wound healing in diabetes. PRO-F can be activated by light and allows real-time tracking of released H2S. It delivers H2S within cells with moderate release efficiency, providing cytoprotective effects against oxidative damage. The potential of PRO-F to enhance chronic wound healing was validated in diabetic models. This study offers new insights into the therapeutic role of H2S donors in complex wound conditions and advances the understanding of H2S-related pathophysiology.
ANALYTICAL CHEMISTRY
(2023)
Article
Surgery
Mingrui Luo, Jin Yu, Can Xin, Miao Hu, Tianshu Tao, Guiping Wan, Jincao Chen, Jianjian Zhang
Summary: We further investigated the vascular specimens of recipient parasylvian cortical arteries (PSCAs) using histological and immunohistochemical methods. Our results showed that the intima of middle cerebral artery (MCA) MMD patients with M-PSCAs was thinner than that of non-M-PSCAs patients. In non-M-PSCAs specimens, HIF-1a and MMP-9 were overexpressed. Logistic regression analysis revealed that M-PSCAs were an independent risk factor for postoperative cerebral hyperperfusion (CHP) syndrome in MMD.
FRONTIERS IN SURGERY
(2023)
Article
Medicine, General & Internal
Mingrui Luo, Jin Yu, Can Xin, Lei Wan, Jianjian Zhang
Summary: A rare case of Moyamoya disease in a 34-year-old pregnant woman was reported in this article. Through comprehensive hemodynamic evaluation and imaging examinations, surgical indications were determined and appropriate treatment methods were chosen. The symptoms were completely relieved after surgery, and there were no further cerebrovascular events during the follow-up period.
Article
Clinical Neurology
Xiao Tian, Miao Hu, Jianjian Zhang
Summary: The aim of this study was to investigate the clinical features and incidence of contralateral progression in Chinese adult patients with Moyamoya disease (MMD). The study found that the contralateral progression rate in Chinese adult patients with unilateral MMD after revascularization was 9.0%, suggesting that some cases of unilateral MMD may be an early form of bilateral MMD.
ACTA NEUROCHIRURGICA
(2022)