KRAS regulation by small non-coding RNAs and SNARE proteins

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

(2017) Fengbiao Zhou et al.   NATURE CELL BIOLOGY

A snoRNA modulates mRNA 3′ end processing and regulates the expression of a subset of mRNAs

(2017) Chunliu Huang et al.   NUCLEIC ACIDS RESEARCH

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

Signal processing by the endosomal system

(2016) Roberto Villaseñor et al.   CURRENT OPINION IN CELL BIOLOGY

Augmenting CRISPR applications in Drosophila with tRNA-flanked sgRNAs

(2016) Fillip Port et al.   NATURE METHODS

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

(2016) Victoria Hung et al.   Nature Protocols

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing

(2016) Marina Falaleeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer

(2015) Zurab Siprashvili et al.   NATURE GENETICS

The many faces of small nucleolar RNAs

(2014) Tomaž Bratkovič et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

A comparative cross-linking strategy to probe conformational changes in protein complexes

(2014) Carla Schmidt et al.   Nature Protocols

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Identification of proteins binding coding and non-coding human RNAs using protein microarrays

(2012) Zurab Siprashvili et al.   BMC GENOMICS

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

(2011) N. Sunaga et al.   MOLECULAR CANCER THERAPEUTICS

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis

(2011) Y-P Mei et al.   ONCOGENE

Ribosome-associated GTPases: The role of RNA for GTPase activation

(2011) Nina Clementi et al.   RNA Biology

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation

(2010) Nina Clementi et al.   Nature Chemical Biology

Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

(2010) Markus Brameier et al.   NUCLEIC ACIDS RESEARCH

Regulation of Ras Localization by Acylation Enables a Mode of Intracellular Signal Propagation

(2010) A. Lorentzen et al.   Science Signaling

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression

(2009) Jason A. Reuter et al.   CANCER CELL

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes

(2009) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Engineering botulinum neurotoxin to extend therapeutic intervention

(2009) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

(2008) Trilochan Sahoo et al.   NATURE GENETICS