Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

(2019) Tim Rasmussen et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimization of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR

(2019) Myrsini Michou et al.   ACS Synthetic Biology

Sensing and transducing forces in plants with MSL10 and DEK1 mechanosensors

(2018) Yannick Guerringue et al.   FEBS LETTERS

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

Elucidating a role for the cytoplasmic domain in the Mycobacterium tuberculosis mechanosensitive channel of large conductance

(2018) Nadia Herrera et al.   Scientific Reports

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Asymmetric mechanosensitivity in a eukaryotic ion channel

(2017) Michael V. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

(2017) Prafulla Aryal et al.   STRUCTURE

Direct Spectroscopic Detection of ATP Turnover Reveals Mechanistic Divergence of ABC Exporters

(2017) Alberto Collauto et al.   STRUCTURE

Exploring conformational equilibria of a heterodimeric ABC transporter

(2017) M Hadi Timachi et al.   eLife

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR

(2016) Silvia Valera et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

(2016) Navid Bavi et al.   Nature Communications

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanosensitive channel of small conductance (MscS) functions as a Jack-In-The Box

(2015) Hannah R. Malcolm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry

(2015) Eamonn Reading et al.   CHEMISTRY & BIOLOGY

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion

(2015) Jie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Probing the Structure of the Mechanosensitive Channel of Small Conductance in Lipid Bilayers with Pulsed Electron-Electron Double Resonance

(2014) Richard Ward et al.   BIOPHYSICAL JOURNAL

The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating

(2014) Nobina Mukherjee et al.   FASEB JOURNAL

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements

(2014) Jinfeng Teng et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Force Transduction and Lipid Binding in MscL: A Continuum-Molecular Approach

(2014) Juan M. Vanegas et al.   PLoS One

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel

(2014) Yong Wang et al.   eLife

Phosphatidylinositol Is Crucial for the Mechanosensitivity of Mycobacterium tuberculosis MscL

(2013) Dalian Zhong et al.   BIOCHEMISTRY

PELDOR in rotationally symmetric homo-oligomers

(2013) Angeliki Giannoulis et al.   MOLECULAR PHYSICS

Quantification of free cysteines in membrane and soluble proteins using a fluorescent dye and thermal unfolding

(2013) Emma Branigan et al.   Nature Protocols

Conformational ensemble of the sodium-coupled aspartate transporter

(2013) Elka R Georgieva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Open and shut: Crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance fromEscherichia coliandHelicobacter pyloriat 4.4 Å and 4.1 Å resolutions

(2013) Jeffrey Y. Lai et al.   PROTEIN SCIENCE

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL

(2012) Gregor Hagelueken et al.   APPLIED MAGNETIC RESONANCE

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS

(2012) T. Nomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy

(2012) C. Pliotas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL

(2012) Julia F. Doerner et al.   Nature Communications

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Mechanosensitive Channels in Microbes

(2010) Ching Kung et al.   Annual Review of Microbiology

Electron Spin-Echo Envelope Modulation (ESEEM) Reveals Water and Phosphate Interactions with the KcsA Potassium Channel,

(2010) John A. Cieslak et al.   BIOCHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rotamer libraries of spin labelled cysteines for protein studies

(2010) Yevhen Polyhach et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Anionic Phospholipids Affect the Rate and Extent of Flux through the Mechanosensitive Channel of Large Conductance MscL†

(2008) Andrew M. Powl et al.   BIOCHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

The Structure of an Open Form of an E. coli Mechanosensitive Channel at 3.45 A Resolution

(2008) W. Wang et al.   SCIENCE