Article
Medicine, Research & Experimental
Qian Cheng, Zhiqing Yang, Xingping Quan, Yuanfu Ding, Junyan Li, Ziyi Wang, Yonghua Zhao, Xiaoyuan Chen, Ruibing Wang
Summary: Inspired by the attraction of fruit flies to polyamines in rotten food, a bio-orthogonal supramolecular homing and hunting strategy was developed. This strategy utilized the elevated levels of polyamines in tumors as natural guest cues to attract CB[7]-functionalized liposomes, resulting in high targeting efficiency, better tissue penetration, and retention in breast tumors. This approach, which uses a receptor functionalized nanomedicine to target endogenous biomarkers in a bio-orthogonal manner, offers new insights for the design of chemotaxis-guided nanoformulations.
Review
Chemistry, Analytical
Bingli Lu, Lingyun Wang, Xueguang Ran, Hao Tang, Derong Cao
Summary: In this review, recent advances in fluorescent methods for polyamine detection and tumor polyamine-suppressing strategies are summarized. This review is of great significance in promoting the development of more efficient polyamine detection methods and providing a comprehensive understanding of polyamine-based tumor suppressor strategies.
Article
Oncology
Hiroshi Kikuchi, Nako Maishi, Li Yu, Zi Jia, Cong Li, Masumi Sato, Ryo Takeda, Keita Ishizuka, Yasuhiro Hida, Nobuo Shinohara, Kyoko Hida
Summary: This study found that LDM CDDP combined with MTD GEM can more effectively inhibit tumor growth and bone metastasis compared to MTD CDDP. LDM CDDP reduces the accumulation of myeloid-derived suppressor cells, while MTD CDDP induces an inflammatory response in the tumor microenvironment.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Quoc Thang Bui, Kuan-Der Lee, Yu-Ching Fan, Branwen S. Lewis, Lih-Wen Deng, Yuan-Chin Tsai
Summary: Cancer cells and MSCs secrete CCL2, which attracts TAMs and promotes malignant progression. Blocking CCL2 expression in MSCs showed anti-tumor effects when injected with prostate cancer cells in mice. The inhibitory effect was associated with an increase of mononuclear myeloid cells in tumors.
Article
Cell Biology
Yang Cheng, Andrew Pitoniak, Julia Wang, Dirk Bohmann
Summary: Aging organisms experience a decline in their ability to adapt to environmental stressors, leading to increased frailty, morbidity, and mortality. Enhancing the expression of protective genes controlled by transcription factors like CncC can support homeostasis and longevity, suggesting pharmacological or dietary interventions targeting stress responsive gene expression as viable anti-aging strategies.
Article
Pharmacology & Pharmacy
Nan Cheng, Xuexia Bai, Yuxin Shu, Owais Ahmad, Pingping Shen
Summary: TAMs are crucial immune cells infiltrating the tumor microenvironment and play complex roles in tumor development, including promoting angiogenesis, invasion, and metastasis, as well as creating an immunosuppressive environment. Targeting TAMs has shown promising results in tumor therapy, with strategies such as inhibiting angiogenesis, blocking immune checkpoints, and enhancing macrophage phagocytosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biophysics
N. Sanoj Rejinold, Huiyan Piao, Geun-woo Jin, Goeun Choi, Jin-Ho Choy
Summary: The global scientific community needs to come up with novel formulations to alleviate the COVID-19 emergency. This study found a potential injectable formulation that can specifically target the SARS-CoV-2 virus with stability and effectiveness.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Andre B. Farias, Graziani Candiotto, Lydia Siragusa, Laura Goracci, Gabriele Cruciani, Edson R. A. Oliveira, Bruno A. C. Horta
Summary: The study analyzed the binding pocket of the key protein Nsp9 in coronavirus viral replication, identified 16 molecules with antiviral activity, and studied their interaction with Nsp9 through molecular docking. The results indicated that the monomer form of Nsp9 has a more stable pocket structure and is more prone to binding with small molecules.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Hui Liu, Chunlei Guo, Yuhong Shang, Lin Zeng, Haixue Jia, Zhongyan Wang
Summary: Supramolecular nanoparticles consisting of peptides and drugs, particularly RGD-conjugated molecular nanoparticles containing the anticancer drug PEM, show enhanced cytotoxic activity and antitumor efficacy compared to PEM alone. These nanoparticles have great potential for application in lung cancer therapy by promoting tumor apoptosis and decreasing mitochondrial energy metabolism.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Marianna Nachef, Alaa Kassim Ali, Saeedah Musaed Almutairi, Seung-Hwan Lee
Summary: Cancer cells create a hostile tumor microenvironment that challenges immune cells' metabolic fitness. Enhancing immune cell metabolism, particularly by upregulating nutrient transporters like glucose and amino acid transporters, can strengthen tumor immunotherapy efforts. Amino acid transporters not only facilitate amino acid uptake but also play a role in sensing amino acid levels and activating key metabolic pathways essential for cell growth and proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Iwona Radziejewska, Katarzyna Supruniuk, Katarzyna Jakimiuk, Michal Tomczyk, Anna Bielawska, Anna Galicka
Summary: Specific changes in mucin-type O-glycosylation, such as incomplete synthesis of glycan structures and overexpression of fucosylation, impact cellular activities promoting cancer development. This study explores the combined action of anti-MUC1 and tiliroside in AGS gastric cancer cells, showing that the combination is more effective than monotherapy in reducing MUC1 expression and influencing cancer-related factors. These findings suggest a promising anti-gastric cancer strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Shupei Tang, Lan Zhou, Haiyang He, Liwei Cui, Zhicheng Ren, Yuhang Tai, Zhunyi Xie, Yi Cao, Dongwei Meng, Qiuli Liu, Yuzhang Wu, Jun Jiang, Xinyuan Zhou
Summary: This study developed a novel cancer vaccine that effectively enhances the immune response against tumor cells in the tumor microenvironment. The vaccine activates immune cells, boosts the production of tumor-specific T cells and pro-inflammatory cytokines, and suppresses tumor growth and metastasis.
Article
Immunology
Le Tian, Shuang Wang, Shasha Jiang, Zeyuan Liu, Xueqi Wan, Chaochao Yang, Li Zhang, Zheng Zheng, Bin Wang, Ling Li
Summary: The study demonstrates that luteolin as a vaccine adjuvant can activate immune responses, enhance tumor-specific CTL responses, and inhibit tolerogenic T cells, showing promising therapeutic effects against malignant melanoma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Shao-Dan Liu, Li-Ping Zhong, Jian He, Yong-Xiang Zhao
Summary: Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins involved in nerve, blood vessel, and tumor development, with NRP1 playing a key role in multiple cancers. NRP1 interacts with various cytokines to affect tumor angiogenesis and proliferation, while NRP1(+) regulatory T cells inhibit tumor immunity. Targeting NRP1 has shown promise in preliminary clinical studies for cancer treatment.
CHINESE MEDICAL JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Jin Huang, Yi Ming Li, Hao Wang, Fang Hui Zhang, Dan Zhang
Summary: Due to the instability of organic materials, inorganic perovskite solar cells (PSCs) have gained much attention. However, the instability of phase and excessive traps in inorganic PSCs have led to inferior performance. To address this, a lead-cerium (Pb-Ce) bimetal based PSC was successfully developed, resulting in improved stability, with a champion power conversion efficiency (PCE) of 17.57% and enhanced tolerance to thermal, illumination, and environmental conditions by 10-20%.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Huifang Wu, Jian Liu, Xiaofeng Huang, Lili Pian, Qianqian Cheng, Qingyang Wang, Min Zhao, Zhou Lin, Beifen Shen, Jiyan Zhang, Shulian Li, Jing Wang
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Guifang Du, Jing Wang, Ting Zhang, Qiang Ding, Xiaodong Jia, Xueke Zhao, Jinke Dong, Xinrui Yang, Shanshan Lu, Cuihong Zhang, Ze Liu, Zhen Zeng, Rifaat Safadi, Ruizhao Qi, Xin Zhao, Zhixian Hong, Yinying Lu
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Naijing Hu, Chunxia Qiao, Jing Wang, Zhihong Wang, Xinying Li, Liuzhong Zhou, Jiaguo Wu, Dingmu Zhang, Jiannan Feng, Beifen Shen, Jinghai Zhang, Longlong Luo
Summary: A novel human antibody named LXY8 was developed in this study to effectively neutralize the toxicity caused by SEB, block the interaction between SEB and the T cell receptor, and inhibit the release of cytokines. Computer-guided molecular modeling identified key residues of SEB important for specific antibody-antigen recognition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang, Yinying Lu
Summary: The study found that the expression of MARCH6 was elevated in human HCC samples and was associated with poor prognosis. Over-expression of MARCH6 promoted cell growth and migration of HCC cells, while its knockdown suppressed these functions. Additionally, MARCH6-mediated up-regulation of ATF2 contributed to HCC development, suggesting MARCH6 may be a promising target for HCC diagnosis and treatment.
Article
Pharmacology & Pharmacy
Zhihong Wang, Naijing Hu, Xinying Li, Haitao Wang, Caiping Ren, Chunxia Qiao, Guojiang Chen, Jing Wang, Liuzhong Zhou, Jiaguo Wu, Dingmu Zhang, Jiannan Feng, Beifen Shen, Hui Peng, Longlong Luo
Summary: Phagocytic resistance is crucial in tumor immune escape, with CD47 being a key immune checkpoint. In this study, an engineered SIRP alpha variant Fc fusion protein, FD164, with higher CD47-binding affinity, was developed, showing promising potential for cancer treatment with improved phagocytic effects and tumor suppression activities. The discovery of FD164 provides a reference for the development of effective and safe anti-tumor drugs targeting CD47.
MOLECULAR PHARMACOLOGY
(2021)
Article
Immunology
Peng Yang, Ying Sun, Min Zhang, Linhan Hu, Xinwei Wang, Longlong Luo, Chunxia Qiao, Jing Wang, He Xiao, Xinying Li, Jiannan Feng, Yu Chen, Yuanqiang Zheng, Yanchun Shi, Guojiang Chen
Summary: Lactic acid, originally a by-product of glucose metabolism, plays a vital role in regulating immune cell polarization, differentiation, and effector functions. However, it impairs the effector function of CD4(+) T cells by decreasing IL-2 and IFN-gamma production as well as CD25/CD69 expression. MCT1 is required for the suppression of CD25 and CD69 expression by lactic acid, but not for its inhibition of IL-2 and IFN-gamma production.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Li Luo, Jiewei Yang, Zhi Li, Hua Xu, Lei Guo, Lili Wang, Yuxia Wang, Longlong Luo, Jing Wang, Pingping Zhang, Ruifu Yang, Weijun Kang, Jianwei Xie
Summary: A novel label-free immunosensor method was developed in this study for differentiation and quantification of ricin and abrin, showing rapid and accurate measurement in various complex matrices. The results demonstrate the potential practical application value of this method.
Article
Engineering, Multidisciplinary
Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo
Summary: Immunotherapy targeting the PD-1/PD-L1 pathway has become a standard treatment for various types of human cancers. This study identified a decoy PD-1 mutant, 463, with significantly increased affinity to PD-L1 and demonstrated inhibitory effects against PD-1, showing potential as a promising option for PD-1/PD-L1-related cancers.
Article
Materials Science, Multidisciplinary
Xiaoqiu Gan, Elvi Angelina, Fangyuan Gu, Kewen Zheng, Lei Cui
Summary: In this study, dual-emission arginine carbon dots were synthesized and used for the determination of uric acid. The method exhibited high selectivity and sensitivity towards uric acid and could be applied in clinical diagnosis. A miniaturized device for uric acid determination was also designed.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Ting-Ting Li, Tian Xia, Jia-Qi Wu, Hao Hong, Zhao-Lin Sun, Ming Wang, Fang-Rong Ding, Jing Wang, Shuai Jiang, Jin Li, Jie Pan, Guang Yang, Jian-Nan Feng, Yun-Ping Dai, Xue-Min Zhang, Tao Zhou, Tao Li
Summary: This study reports the de novo assembly of a cattle genome and provides a detailed annotation of the immunogenomic loci. The immunogenomic regions, including immunoglobulin (IG) loci, T-cell receptor (TR) loci, and the major histocompatibility complex (MHC) locus, are seamlessly assembled and precisely annotated. The characterization of immune genes in cattle reveals their diversity and the MHC gene structures are also revealed with properly phased haplotypes.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ting Zhang, Xinrui Yang, Wanping Xu, Jing Wang, Dawei Wu, Zhixian Hong, Shengxian Yuan, Zhen Zeng, Xiaodong Jia, Shanshan Lu, Rifaat Safadi, Sen Han, Zhihong Yang, Leonard M. Neckers, Suthat Liangpunsakul, Weiping Zhou, Yinying Lu
Summary: The study reveals that HSP90 interacts with DDX5 protein and protects it from AMPK/ULK1-regulated autophagic degradation. DDX5 and HSP90 are potential therapeutic targets for HCC, as high levels of HSP90 and DDX5 protein are associated with poor prognoses.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Caiyue Wang, Shuping Zhang, Junhai Huang, Lei Cui, Jin Hu, Shaoying Tan
Article
Chemistry, Multidisciplinary
Hongdong Yuan, Chongrong Tang, Shikuan Su, Lei Cui, Xueshun Jia, Chunju Li, Jian Li
CHEMICAL COMMUNICATIONS
(2019)