Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

(2017) Teresa Ramirez et al.   JOURNAL OF HEPATOLOGY

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

(2017) Xue-Ke Zhao et al.   Scientific Reports

Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology

(2016) Raghuveera Kumar Goel et al.   CANCER AND METASTASIS REVIEWS

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3

(2016) Hye-Young Seo et al.   KIDNEY INTERNATIONAL

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase

(2015) Pulin Che et al.   Scientific Reports

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

(2014) X. Zhang et al.   JOURNAL OF CELL SCIENCE

Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation

(2012) Guo-Qiang Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibrosis-dependent mechanisms of hepatocarcinogenesis

(2012) David Y. Zhang et al.   HEPATOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells

(2011) An Na Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGF-β1 Induces Podocyte Injury Through Smad3-ERK-NF-κB Pathway and Fyn-dependent TRPC6 phosphorylation

(2011) Lixia Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study

(2009) Primo N. Lara et al.   ANTI-CANCER DRUGS

Actin filament nucleation and elongation factors – structure–function relationships

(2009) Roberto Dominguez   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

Src kinases in systemic sclerosis: Central roles in fibroblast activation and in skin fibrosis

(2008) Catherine Skhirtladze et al.   ARTHRITIS AND RHEUMATISM

Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner

(2008) Qiang Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530

(2008) Y-M Chang et al.   ONCOGENE