Article
Oncology
Saeka Egami, Hitoshi Kawazoe, Hironobu Hashimoto, Ryuji Uozumi, Toko Arami, Naomi Sakiyama, Yuichiro Ohe, Hideo Nakada, Tohru Aomori, Shinnosuke Ikemura, Koichi Fukunaga, Masakazu Yamaguchi, Tomonori Nakamura
Summary: This study aimed to investigate the association between immune-related adverse events (irAEs) and peripheral blood cell counts in patients receiving pembrolizumab for advanced non-small cell lung cancer (NSCLC). The results showed that patients with higher pretreatment absolute lymphocyte count (ALC) and lymphocyte-to-monocyte ratio (LMR) had a reduced risk of developing any irAEs, while patients with higher pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) had an increased risk. Routine evaluation of blood cell count data before pembrolizumab treatment initiation may help identify early-onset irAEs during the first 6 weeks of treatment.
Article
Oncology
Saeka Egami, Hitoshi Kawazoe, Hironobu Hashimoto, Ryuji Uozumi, Toko Arami, Naomi Sakiyama, Yuichiro Ohe, Hideo Nakada, Tohru Aomori, Shinnosuke Ikemura, Koichi Fukunaga, Masakazu Yamaguchi, Tomonori Nakamura
Summary: This study found that an absolute lymphocyte count >820 at 2 weeks following nivolumab initiation predicts the early onset of immune-related adverse events during a 6-week study period in patients with advanced non-small cell lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Feng Wang, Limin Chen, Zhao Wang, Qiuyan Xu, He Huang, Hairong Wang, Xi Li, Mingjie Yu, Jiangen Chen, Fuhua Lin, Zhenghe Chen, Xiangheng Zhang, Qunying Yang, Yonggao Mou, Chengcheng Guo
Summary: This study aimed to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel prognostic index for NSCLC patients with BM.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Wenhui Liu, Yiping Liu, Fang Ma, Bao Sun, Ying Wang, Jianquan Luo, Mouze Liu, Zhiying Luo
Summary: This study found a significant association between low baseline levels of NLR, PLR, and neutrophil and the development of severe irAEs in NSCLC patients treated with PD-1 inhibitors. When irAEs occurred, levels of neutrophil, NLR, and PLR also decreased significantly compared to baseline.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Oncology
Weibo Cao, Haochuan Yu, Shuai Zhu, Xi Lei, Tong Li, Fan Ren, Ning Zhou, Quanying Tang, Lingling Zu, Song Xu
Summary: Elevated preoperative NLR and PLR are found to be prognostic biomarkers in resected early-stage NSCLC cases, indicating their value in guiding postoperative adjuvant treatment.
Article
Oncology
Anna Cho, Helena Untersteiner, Dorian Hirschmann, Fabian Fitschek, Christian Dorfer, Karl Roessler, Sabine Zoechbauer-Mueller, Brigitte Gatterbauer, Maximilian J. Hochmair, Josa M. Frischer
Summary: The study assessed the predictive value of NLR, PLR, LMR, and mGPS for NSCLC brain metastases patients undergoing radiosurgery. The results indicated that these factors are independent prognostic factors for survival.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Alex K. K. Bryant, Kamya Sankar, Garth W. W. Strohbehn, Lili Zhao, David Elliott, Angel Qin, Sarah Yentz, Nithya Ramnath, Michael D. D. Green
Summary: This study demonstrates that pre-treatment NLR is a prognostic factor in stage III NSCLC patients treated with adjuvant immunotherapy, and it may also serve as a predictive biomarker of immunotherapy benefit.
Article
Immunology
Yuxin Wang, Jiahui Lu, Chenxi Wu, Fei Fei, Zhuze Chu, Peihua Lu
Summary: This study investigated the relationship between new haematological and pathological markers and clinical outcomes in NSCLC patients receiving ICIs. The results showed that low baseline neutrophil-to-lymphocyte ratio in peripheral blood and high expression of CD8 in tissues were associated with longer progression-free survival, potentially serving as predictive factors for the efficacy of ICIs in stage III-IV NSCLC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Si-Min Peng, Jin-Jin Ren, Na Yu, Jia-Ying Xu, Guo-Chong Chen, Xiaodong Li, Da-Peng Li, Jing Yang, Zeng-Ning Li, Yu-Song Zhang, Li-Qiang Qin
Summary: The Naples prognostic score (NPS) is a valuable prognostic factor for non-small-cell lung cancer (NSCLC) patients, as it is associated with overall survival (OS) and progress-free survival (PFS). NPS is an independent prognostic factor for OS and PFS, and it has predictive performance in different stages of NSCLC.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Heather Wakelee, Moishe Liberman, Terufumi Kato, Masahiro Tsuboi, Se-Hoon Lee, Shugeng Gao, Ke-Neng Chen, Christophe Dooms, Margarita Majem, Ekkehard Eigendorff, Gaston L. Martinengo, Olivier Bylicki, Delvys Rodriguez-Abreu, Jamie E. E. Chaft, Silvia Novello, Jing Yang, Steven M. M. Keller, Ayman Samkari, Jonathan D. D. Spicer
Summary: Among patients with resectable early-stage NSCLC, perioperative pembrolizumab improved event-free survival, major pathological response, and pathological complete response. The addition of pembrolizumab to neoadjuvant chemotherapy followed by surgery showed significant benefits compared to neoadjuvant chemotherapy alone followed by surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Toshiki Ogiwara, Hitoshi Kawazoe, Saeka Egami, Hironobu Hashimoto, Yoshimasa Saito, Naomi Sakiyama, Yuichiro Ohe, Masakazu Yamaguchi, Tetsuya Furukawa, Azusa Hara, Yui Hiraga, Aya Jibiki, Yuta Yokoyama, Sayo Suzuki, Tomonori Nakamura
Summary: The combination of baseline medications with nivolumab or pembrolizumab and neutrophil-to-lymphocyte ratio (NLR) may lead to shorter survival outcomes in patients with advanced NSCLC and serve as a prognostic index for poor outcomes. A significant association was found between the prognostic score and overall survival (OS) in 259 patients, but not with progression-free survival (PFS). Further validation in a large-scale multicenter study is needed to confirm these findings for clinical application.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chester Kao, Eric Powers, Yuan Wu, Michael B. Datto, Michelle F. Green, John H. Strickler, Neal E. Ready, Tian Zhang, Jeffrey M. Clarke
Summary: In this study of 88 NSCLC patients, tumor mutational burden (TMB), PD-L1, and NLR were found to be modest biomarkers for response to immune checkpoint inhibitors. TMB was the strongest predictor, but combining all three biomarkers improved the prediction of treatment response.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Karen Huang, Sharan Prasad, Sung Jun Ma, Han Yu, Austin J. J. Iovoli, Mark K. K. Farrugia, Elizabeth U. U. Dexter, Todd L. L. Demmy, Nadia K. K. Malik, Anurag K. K. Singh
Summary: This observational cohort study found that pretreatment neutrophil-lymphocyte ratio (NLR) is an independent predictor for survival outcomes of early-stage NSCLC patients treated with single fraction SBRT. The study showed that NLR, as a continuous variable, is independently associated with overall survival and progression-free survival, as well as disease-free survival.
Review
Oncology
David Smith, Micaela Raices, Federico Cayol, Franco Corvatta, Lucas Caram, Agustin Dietrich
Summary: Inflammation plays a key role in malignant tumor progression. The neutrophil-to-lymphocyte ratio (NLR) is an indicator of systemic inflammation and high NLR before treatment has been associated with worse long-term outcomes in some studies. We summarize the data on the use of NLR as a prognostic factor and present the results of a single institution study evaluating the usefulness of high preoperative NLR as a prognostic factor in patients with resected NSCLC who receive adjuvant cisplatin-based chemotherapy. Our study, along with existing literature, supports the use of preoperative NLR as a reliable and cost-effective biomarker for estimating prognosis in NSCLC patients.
SEMINARS IN ONCOLOGY
(2022)
Article
Biology
Xing Li, Jie Chen, Yong-Jian Chen, Yi-Dan Qiao, Li-Yun Zhao, Nan Jiang, Xiang-Yuan Wu, Yan-Fang Xing
Summary: Li et al. demonstrate that dexamethasone and lactoferrin induced polymorphonuclear myeloid-derived suppressor cells relieve inflammatory conditions in mouse models with minimal effect on tumour growth, showing promise for combating inflammatory adverse events during anti-cancer treatments.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Ding-Yun Feng, Xiao-Ling Zou, Yu-Qi Zhou, Wen-Bin Wu, Hai-Ling Yang, Tian-Tuo Zhang
Summary: This study evaluated factors predicting CAP-related in-hospital mortality in elderly patients and found that NLR*CURB-65 is a simpler and more accurate predictor. Patients with high NLR*CURB-65 levels had higher in-hospital mortality, and significant differences were observed in age, sex, smoking history, comorbidity, and laboratory findings between the two groups divided based on NLR*CURB-65 levels.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Qu Lin, Ming-Jun Bai, Hao-Fan Wang, Xiang-Yuan Wu, Ming-Sheng Huang, Xing Li
Summary: In this case study, exclusive mutations of APC in all the Wnt pathway elements were found to be a potential therapeutic target in hepatitis B-related hepatocellular carcinoma (HCC). Aspirin was administered to the patient with these mutations, resulting in four years of disease control.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Health Care Sciences & Services
Ding-Yun Feng, Yong Ren, Mi Zhou, Xiao-Ling Zou, Wen-Bin Wu, Hai-Ling Yang, Yu-Qi Zhou, Tian-Tuo Zhang
Summary: This study utilized machine learning techniques to establish an accurate model for predicting CAP mortality, with deep learning methods showing excellent performance. The ensemble FCNN model achieved good results in prognosis classification, confirming the importance of clinical-related features for prognosis.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Public, Environmental & Occupational Health
Jun-Jian Qin, Yan-Fang Xing, Jian-Hua Ren, Yong-Jian Chen, Ying-Fei Gan, Yan-Qiu Jiang, Jie Chen, Xing Li
Summary: The study indicated an association between mandatory mask-wearing and reinforced hand hygiene education and decreased respiratory, catheter-related, and digestive tract infection episodes in the hemodialysis unit during the COVID-19 pandemic.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Allergy
Xiao-Ling Zou, Jin-Jie Wu, Hui-Xia Ye, Ding-Yun Feng, Ping Meng, Hai-Ling Yang, Wen-Bin Wu, Hong-Tao Li, Zhen He, Tian-Tuo Zhang
Summary: The study identified distinct taxonomic compositions of gut microbiota in different asthmatic phenotypes, with significant relationships between specific microbial species and clinical characteristics. Specific microbial combinations and pathways showed potential as classifiers of different asthma phenotypes, especially in distinguishing between allergic and non-allergic asthmatics. These findings suggest the potential importance of intestinal microbial signatures in delineating asthma phenotypes.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Immunology
Gaoyu Liu, Yingying Chen, Ying Wang, Xiaohui Deng, Qiang Xiao, Lijuan Zhang, Haixu Xu, Xu Han, Aihua Lei, Juan He, Xing Li, Yingjiao Cao, Pan Zhou, Chunhui He, Peiqiong Wu, Wenhui Jiang, Meizheng Tan, Chun Chen, Quan Yang, Liwei Lu, Kai Deng, Zhi Yao, Jie Zhou
Summary: This study identifies angiotensin II as a positive regulator of ILC2s and demonstrates its role in driving allergic airway inflammation. Plasma levels of angiotensin II correlate positively with circulating ILC2 abundance and disease severity in asthmatic patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Juan He, Guanmin Jiang, Xing Li, Qiang Xiao, Yingying Chen, Haixu Xu, Gaoyu Liu, Aihua Lei, Pan Zhou, Kun Shi, Quan Yang, Meng Zhao, Zhi Yao, Jie Zhou
Summary: Bilirubin, an end product of heme catabolism, was shown to be a potent negative regulator of ILC2s, suppressing their responses to IL-33 and alleviating airway inflammation. Mechanistic studies revealed that bilirubin exerts its effects on ILC2s through downregulation of ERK phosphorylation and GATA3 expression. Clinical evidence suggested that newborns with hyperbilirubinemia exhibited lower levels of functional ILC2 and suppressed ERK signaling. These findings suggest that bilirubin may have therapeutic potential in the treatment of allergic airway inflammation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Respiratory System
Haiyu Zhou, Lili Lin, Tao Qin, Wei Ren, Yujie Tan, Qiong Yang, Huixin Xu, Xinxin Xie, Yongjian Chen, Shengbo Liu, Xing Li, Zhihua Li, Hai Hu, Yunfang Yu, Herui Yao
Summary: This study aims to investigate the effect of neoadjuvant therapy on stage IIB-III NSCLC patients and establish a multiomics artificial intelligence system for predicting efficacy and assisting decision-making. The research methods involve preoperative treatment with neoadjuvant therapy drugs and evaluation of multiple clinical endpoints.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Microbiology
Su-fang Kuang, Xia Li, Ding-Yun Feng, Wen-Bin Wu, Hui Li, Bo Peng, Xuan-xian Peng, Zhuang-gui Chen, Tian-tuo Zhanga
Summary: This study reveals that nitrite enhances the killing efficacy of cefoperazone-sulbactam against Pseudomonas aeruginosa by activating the pyruvate cycle and increasing reactive oxygen species.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Ding-Yun Feng, Jian-Xia Zhou, Xia Li, Wen -Bin Wu, Yu-Qi Zhou, Tian-Tuo Zhang
Summary: This study evaluated factors that differentiate infection from colonization and predicted mortality in patients with nosocomial pneumonia caused by A. baumannii. The results showed that age, total number of inpatient departments, absolute neutrophil count, and C-reactive protein level helped distinguish between infection and colonization. Several novel predictors were associated with in-hospital mortality. The study highlights the importance of identifying A. baumannii pneumonia and predicting the risk of death to reduce mortality.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Biotechnology & Applied Microbiology
Jian-Xia Zhou, Ding-Yun Feng, Xia Li, Jia-Xin Zhu, Wen-Bin Wu, Tian-tuo Zhang
Summary: Acinetobacter baumannii is a highly infectious and invasive pathogen that is resistant to many antimicrobial treatments. Recent studies have identified virulence factors associated with this pathogen's pathogenesis, offering potential therapeutic targets. This review provides a comprehensive summary of these factors and their mechanisms, along with suggestions for future research and clinical applications.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Allergy
Kang-ni Feng, Ping Meng, Min Zhang, Xiao-ling Zou, Shuang Li, Chu-qin Huang, Ke-fang Lai, Hong-tao Li, Tian-tuo Zhang
Summary: IL-24 aggravates neutrophilic airway inflammation by increasing epithelium-derived IL-17A production, which can be suppressed by IL-37. Targeting the IL-24/IL-17A signaling axis is a potential strategy, and IL-37 is a potential candidate agent for alleviating neutrophilic airway inflammation in asthma.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Yong-Jian Chen, Wei-Xin Liao, Shao-Zhuo Huang, Yun-Fang Yu, Jing-Yun Wen, Jie Chen, Da-Gui Lin, Xiang-Yuan Wu, Nan Jiang, Xing Li
Summary: The study identified the expression and prognostic value of CD36 in multiple cancer types. Additionally, CD36 expression was significantly associated with current predictors for the efficacy of immune checkpoint inhibitors (ICIs) with disease-specific patterns.