Design and demonstration of a pumpless 14 compartment microphysiological system

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Systematic Reviews of Animal Models: Methodology versus Epistemology

(2013) Ray Greek et al.   International Journal of Medical Sciences

Blood Flow in Capillaries of the Human Lung

(2013) Shimon Haber et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Microphysiological systems and low-cost microfluidic platform with analytics

(2013) Alec ST Smith et al.   Stem Cell Research & Therapy

Modeling Life

(2012) Michael L. Shuler   ANNALS OF BIOMEDICAL ENGINEERING

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

(2011) Anupama Natarajan et al.   BIOMATERIALS

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

An open-access microfluidic model for lung-specific functional studies at an air-liquid interface

(2009) Divya D. Nalayanda et al.   BIOMEDICAL MICRODEVICES

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS