Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

(2019) Gina Song et al.   TOXICOLOGICAL SCIENCES

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations

(2018) Laura Hedges et al.   XENOBIOTICA

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes

(2018) Laura Hedges et al.   XENOBIOTICA

The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study using Bromodichloromethane (BDCM)

(2018) E M Kenyon et al.   TOXICOLOGICAL SCIENCES

Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability

(2017) Caroline L. Ring et al.   ENVIRONMENT INTERNATIONAL

Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause

(2017) Christopher D. Ruark et al.   ENVIRONMENT INTERNATIONAL

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

(2016) Mikael Boberg et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche

(2016) Gina Song et al.   ENVIRONMENTAL RESEARCH

PBPK modeling of the cis - and trans -permethrin isomers and their major urinary metabolites in rats

(2016) Marie-Emilie Willemin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Addressing the Challenges of Low Clearance in Drug Research

(2015) Li Di et al.   AAPS Journal

Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

(2015) Huali Wu et al.   ENVIRONMENT INTERNATIONAL

Time profiles and toxicokinetic parameters of key biomarkers of exposure to cypermethrin in orally exposed volunteers compared with previously available kinetic data following permethrin exposure

(2015) Mylène Ratelle et al.   JOURNAL OF APPLIED TOXICOLOGY

Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine and deltamethrin

(2015) Pankaj K. Sethi et al.   PEDIATRIC RESEARCH

In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes

(2015) M.-E. Willemin et al.   TOXICOLOGY IN VITRO

Toxicokinetics of permethrin biomarkers of exposure in orally exposed volunteers

(2015) Mylène Ratelle et al.   TOXICOLOGY LETTERS

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies

(2012) Shakil Ahmed Saghir et al.   CRITICAL REVIEWS IN TOXICOLOGY

Quantitativein vitrotoin vivoextrapolation of cell-based toxicity assay results

(2012) Miyoung Yoon et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Pharmacokinetic Model of cis- and trans-Permethrin Disposition in Rats and Humans With Aggregate Exposure Application

(2012) Rogelio Tornero-Velez et al.   TOXICOLOGICAL SCIENCES

Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances

(2011) David M. Soderlund   ARCHIVES OF TOXICOLOGY

Age, Dose, and Time-Dependency of Plasma and Tissue Distribution of Deltamethrin in Immature Rats

(2010) Kyu-Bong Kim et al.   TOXICOLOGICAL SCIENCES

Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

(2010) Rogelio Tornero-Velez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver

(2009) H.-J. Zhu et al.   DRUG METABOLISM AND DISPOSITION

Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population

(2009) Ronald N. Hines et al.   TOXICOLOGICAL SCIENCES

Lactational Transfer of Manganese in Rats: Predicting Manganese Tissue Concentration in the Dam and Pups from Inhalation Exposure with a Pharmacokinetic Model

(2009) Miyoung Yoon et al.   TOXICOLOGICAL SCIENCES

Lymphatic and portal vein absorption of organochlorine compounds in rats

(2008) Ronald J. Jandacek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

(2008) Dongfang Yang et al.   BIOCHEMICAL PHARMACOLOGY

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms

(2008) E. J. Scollon et al.   DRUG METABOLISM AND DISPOSITION

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS