N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
出版年份 2019 全文链接
标题
N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 47, Pages 23426-23436
出版商
Proceedings of the National Academy of Sciences
发表日期
2019-11-05
DOI
10.1073/pnas.1916318116
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
- (2018) Ju Youn Lee et al. Nature Communications
- Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
- (2018) Masha G. Savelieff et al. CHEMICAL REVIEWS
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease
- (2017) Yasuhisa Ano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity
- (2017) Wei-Xing Zhao et al. Journal of Neuroinflammation
- AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
- (2017) Soraya Wilke Saliba et al. Journal of Neuroinflammation
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
- (2016) Michael W. Beck et al. Nature Communications
- Molecules with O-acetyl group protect protein glycation by acetylating lysine residues
- (2016) Garikapati Vannuruswamy et al. RSC Advances
- NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes
- (2015) Sorina Georgiana Boaru et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms
- (2015) Jeffrey S. Derrick et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Immune attack: the role of inflammation in Alzheimer disease
- (2015) Frank L. Heppner et al. NATURE REVIEWS NEUROSCIENCE
- Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
- (2015) Marie-Victoire Guillot-Sestier et al. NEURON
- Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
- (2015) Inge R Holtman et al. Acta Neuropathologica Communications
- Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
- (2014) E Sim et al. BRITISH JOURNAL OF PHARMACOLOGY
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice
- (2013) Rodrigo Medeiros et al. AMERICAN JOURNAL OF PATHOLOGY
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- The microglial sensome revealed by direct RNA sequencing
- (2013) Suzanne E Hickman et al. NATURE NEUROSCIENCE
- Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
- (2013) Grietje Krabbe et al. PLoS One
- Quantitating the subtleties of microglial morphology with fractal analysis
- (2013) Audrey Karperien et al. Frontiers in Cellular Neuroscience
- Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
- (2013) L. Mucke et al. Cold Spring Harbor Perspectives in Medicine
- The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
- (2012) I. W. Hamley CHEMICAL REVIEWS
- The influence of lipophilicity in drug discovery and design
- (2012) John A Arnott et al. Expert Opinion on Drug Discovery
- Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology
- (2012) A. D. Bachstetter et al. JOURNAL OF NEUROSCIENCE
- Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease
- (2012) S. Mandrekar-Colucci et al. JOURNAL OF NEUROSCIENCE
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Misfolded proteins in Alzheimer's disease and type II diabetes
- (2011) Alaina S. DeToma et al. CHEMICAL SOCIETY REVIEWS
- Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
- (2011) Thomas Philips et al. LANCET NEUROLOGY
- Role of the Nlrp3 Inflammasome in Microbial Infection
- (2011) Paras K. Anand et al. Frontiers in Microbiology
- Conditioned media from cell lines: A complementary model to clinical specimens for the discovery of disease-specific biomarkers
- (2010) Paul Dowling et al. PROTEOMICS
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Neuroinflammation in Parkinson's disease: a target for neuroprotection?
- (2009) Etienne C Hirsch et al. LANCET NEUROLOGY
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- The NF- B Family of Transcription Factors and Its Regulation
- (2009) A. Oeckinghaus et al. Cold Spring Harbor Perspectives in Biology
- The Nuclear Factor NF- B Pathway in Inflammation
- (2009) T. Lawrence Cold Spring Harbor Perspectives in Biology
- Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein
- (2008) Vivian Y. H. Hook et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microglial Dysfunction and Defective -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
- (2008) S. E. Hickman et al. JOURNAL OF NEUROSCIENCE
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Prodrugs: design and clinical applications
- (2008) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
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