Role of fluid shear stress in regulating VWF structure, function and related blood disorders

No evidence for a direct effect of von Willebrand factor's ABH blood group antigens on von Willebrand factor clearance

(2015) D. J. Groeneveld et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count

(2015) S. Lancellotti et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF

(2014) C. J. Lynch et al.   BLOOD

Shear-Stress-Induced Conformational Changes of von Willebrand Factor in a Water–Glycerol Mixture Observed with Single Molecule Microscopy

(2014) Robrecht M. A. Vergauwe et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Allosteric activation of ADAMTS13 by von Willebrand factor

(2014) Joshua Muia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational activation of ADAMTS13

(2014) Kieron South et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxyl Terminus of ADAMTS13 Directly Inhibits Platelet Aggregation and Ultra Large von Willebrand Factor String Formation Under Flow in a Free-Thiol–Dependent Manner

(2013) Jialing Bao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

(2013) N. Rydz et al.   BLOOD

The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story

(2013) T. Nightingale et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The O-linked glycans of human von Willebrand factor modulate its interaction with ADAMTS-13

(2013) A. A. Nowak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

(2012) Nathalie Saint-Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Direct Observation of von Willebrand Factor Elongation and Fiber Formation on Collagen During Acute Whole Blood Exposure to Pathological Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mapping the N-glycome of human von Willebrand factor

(2012) Kevin Canis et al.   BIOCHEMICAL JOURNAL

von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesion

(2012) S. R. Madabhushi et al.   BLOOD

Sequence and structure relationships within von Willebrand factor

(2012) Y.-F. Zhou et al.   BLOOD

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions

(2012) A. A. Nowak et al.   BLOOD

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5

(2012) J. N. Pegon et al.   HAEMATOLOGICA

Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis

(2012) S. KANAJI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

(2011) J. T. B. Crawley et al.   BLOOD

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

(2011) T. Ganderton et al.   BLOOD

A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13

(2011) M. Zhou et al.   BLOOD

A pH-regulated dimeric bouquet in the structure of von Willebrand factor

(2011) Yan-Feng Zhou et al.   EMBO JOURNAL

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

(2011) Junmei Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity

(2010) Kannayakanahalli M. Dayananda et al.   ANALYTICAL BIOCHEMISTRY

von Willebrand factor self-association on platelet GpIb  under hydrodynamic shear: effect on shear-induced platelet activation

(2010) K. M. Dayananda et al.   BLOOD

A mechanically stabilized receptor–ligand flex-bond important in the vasculature

(2010) Jongseong Kim et al.   NATURE

Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro

(2010) Anyou Wang et al.   THROMBOSIS RESEARCH

Fluid Shear Induces Conformation Change in Human Blood Protein von Willebrand Factor in Solution

(2009) Indrajeet Singh et al.   BIOPHYSICAL JOURNAL

Application of Fluorescence Spectroscopy to Quantify Shear-Induced Protein Conformation Change

(2009) Efrosyni Themistou et al.   BIOPHYSICAL JOURNAL

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

(2009) T. J. Raife et al.   BLOOD

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

The plasma von Willebrand factorO-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs

(2009) K. CANIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Integrin  v 3 on human endothelial cells binds von Willebrand factor strings under fluid shear stress

(2008) J. Huang et al.   BLOOD

Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions

(2008) Y. LI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

N-linked glycosylation of VWF modulates its interaction with ADAMTS13

(2007) T. A. J. McKinnon et al.   BLOOD

Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

(2007) K. Shim et al.   BLOOD