Article
Chemistry, Medicinal
Huda K. Mahmoud, Abdelwahed R. Sayed, Marwa M. Abdel-Aziz, Sobhi M. Gomha
Summary: This study aims to synthesize bioactive hybrid pharmacophores and assess their antimycobacterial activity. The results showed that derivative 7b exhibited the most promising antimycobacterial activity among the tested compounds. The structure-activity relationship studies indicated that the substituent on the thiazole ring was related to the antimycobacterial activity.
MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tianming Zhao, Yu Yang, Jing Yang, Youbao Cui, Zhi Cao, Daiying Zuo, Xin Zhai
Summary: Standard chemotherapy and personalized target therapies are commonly used in advanced nonsmall cell lung cancer patients, but multidrug resistance and tumor metastasis often lead to decreased efficacy, associated with epithelial-mesenchymal transition (EMT). The transcription factor Twist1 plays a key role in promoting EMT, MDR, and metastasis, making it a potential target for developing antitumor therapies. By designing novel benzo[d] imidazo[2,1-b]thiazole derivatives with 1,3,4-oxadiazole moiety based on the structure of Twist1 inhibitor harmine, a compound with superior anti-proliferative activity and Twist1 down-regulation potential was identified as a promising lead for antineoplastic treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Menna A. Ewida, Heba A. Ewida, Mahmoud S. Ahmed, Heba Abdelrasheed Allam, Ramzia ElBagary, Riham F. George, Hanan H. Georgey, Hussein El-Subbagh
Summary: A series of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole analogs were synthesized and evaluated for their inhibitory effects on IDO1, with several compounds showing promising activity. Molecular modeling simulations suggested that these analogs can chelate iron(III) within the IDO1 binding pocket and have better binding affinity through hydrophobic interactions.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Multidisciplinary
Esteban Rodriguez-Arce, Eric Gavrilov, Ximena Alvite, Nazia Nayeem, Ignacio E. Leon, Michelle C. Neary, Lucia Otero, Dinorah Gambino, Claudio Olea Azar, Maria Contel
Summary: This work reports the synthesis and stability study of four gold(I) [AuClL] compounds containing chloro and biologically active protonated thiosemicarbazones based on 5-nitrofuryl (L=HSTC). The cytotoxicity of these compounds was evaluated against cancer cell lines, and one compound showed significant antimigratory and anti-angiogenic properties on a renal cancer cell line (Caki-1), along with preferential accumulation in the cell nuclei. Its mode of action seems to involve interaction with DNA and induction of apoptosis.
Article
Biochemical Research Methods
Diana L. Nossa Gonzalez, Jovanny A. Gomez Castano, Wilson E. Rozo Nunez, Pablo R. Duchowicz
Summary: Chagas disease, caused by Trypanosoma cruzi, affects around 8 million people globally and causes 12,000 deaths annually. Traditional chemotherapy with Benznidazole and Nifurtimox has limitations. Recent research focuses on finding new chemical structures with better efficacy and tolerance. Thiosemicarbazone and thiazole derivatives show promising in vitro activity against T. cruzi.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2021)
Article
Biochemistry & Molecular Biology
Rawan M. Sbenati, Mohammad H. Semreen, Ahlam M. Semreen, Mahmoud K. Shehata, Fai M. Alsaghir, Mohammed El-Gamal
Summary: This article reviewed the potential anticancer properties of imidazo[2,1-b]thiazole derivatives, focusing on their biological characteristics and structure-activity relationship (SAR). Reports published in the literature from 2011 to 2020 were the main focus of this review.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Paulo Fernando da S. Santos-Junior, Igor Jose dos S. Nascimento, Edjan Carlos D. da Silva, Kadja Luana C. Monteiro, Johnnatan D. de Freitas, Samaysa de Lima Lins, Thamilla Maria S. Maciel, Bruno C. Cavalcanti, Jose de Brito V. Neto, Fabiane C. de Abreu, Isis M. Figueiredo, Josue Carinhanha C. Santos, Claudia do O. Pessoa, Edeildo F. da Silva-Junior, Joao X. de Araujo-Junior, Thiago M. de Aquino
Summary: The study describes the synthesis of hybrid compounds containing quinoline and indole nucleus under ultrasound irradiation, with some compounds showing promising cytotoxic activity against HL-60 cancer cell line. Electrochemical and spectroscopic techniques were used to analyze the interaction between a selected compound and DNA. The results suggest the compound acts preferentially as a groove binder and can serve as a potential anticancer prototype against HL-60.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Surendar Chitti, Kevin Van Calster, Davie Cappoen, Adinarayana Nandikolla, Yogesh Mahadu Khetmalis, Paul Cos, Banoth Karan Kumar, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar
Summary: In the search for new anti-mycobacterial agents, the importance of imidazo-[2,1-b]-thiazole and benzo-[d]-imidazo-[2,1-b]-thiazole carboxamide derivatives was revealed. Several series of novel derivatives were designed, predicted, and synthesized. The most active derivatives showed selective inhibition against Mycobacterium tuberculosis and no activity against non-tuberculous mycobacteria. Molecular docking and dynamics studies were also conducted to understand the binding pattern and stability of the protein-ligand complex.
Article
Chemistry, Multidisciplinary
Lakshmi Haritha Bharathi Maganti, Deepthi Ramesh, Balaji Gowrivel Vijayakumar, Mohd Imran K. Khan, Arunkumar Dhayalan, Jayabal Kamalraja, Tharanikkarasu Kannan
Summary: This study synthesized acetylene derivatives with anti-Mycobacterium tuberculosis activity and evaluated their efficacy in vitro. Several compounds showed strong inhibition of the growth of Mycobacterium tuberculosis without toxicity to human cells.
Article
Chemistry, Medicinal
Mohammed S. Abdel-Maksoud, Mohammed El-Gamal, Bong S. Lee, Mahmoud M. Gamal El-Din, Hong R. Jeon, Dow Kwon, Usama M. Ammar, Karim Mersal, Eslam M. H. Ali, Kyung-Tae Lee, Kyung Ho Yoo, Dong Keun Han, Jae Kyun Lee, Garam Kim, Hong Seok Choi, Young Jik Kwon, Kwan Hyi Lee, Chang Hyun Oh
Summary: In this study, a series of new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives with a terminal sulfonamide moiety were synthesized and their pan-RAF inhibitory effect was investigated. Compounds 27c and 38a showed the highest antiproliferative activity against cancer cells and were able to inhibit phosphorylation of MEK and ERK. Compound 38a was further tested for its in vivo activity against melanoma, and both cellular and animal activities were reported.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Dongdong Zhang, Yixin Hu, Zhiqiang Hao, Yang Zhang, Shuhua Luo, Xin Dang, Ran Sun, Shixin Duan, Dan Lv, Faqin Jiang, Lei Fu
Summary: A novel batch of thiazole-containing mitochondrial targeting agents were designed and synthesized, with D1 exhibiting strong antiproliferative activity and significant mitochondrial inhibition on HeLa cancer cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Chuchu Li, Yuqiao Han, Zhengyang Wang, Yanan Yu, Chen Wang, Ziwei Ren, Yanzhi Guo, Tong Zhu, XuWen Li, Suzhen Dong, Mingliang Ma
Summary: Compound 42 showed excellent dual PI3K/mTOR inhibitory activity, significant in vitro and in vivo anti-tumoral activities, good kinase selectivity, low hepatotoxicity, modest plasma clearance and acceptable oral bioavailability. It is a promising PI3K/mTOR targeted anti-cancer drug candidate.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Rizk E. Khidre, Ibrahim Ali M. Radini
Summary: A series of novel compounds were synthesized and evaluated for their potential as DNA gyrase inhibitors and antimicrobial agents. Among them, compound 13a exhibited good antibacterial and antifungal activities.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Ai-hui Zhou, Tao Han, Peng-bin Si, Xiao-qing Liu, Ming-yu Teng, Guo-li Huang, Bo Liu, Qin Wang, Jie Zhang
Summary: Eight iridium complexes were synthesized for applications in organic optical function materials, using 3-methyl-6-(naphthalen-2-yl)-imidazo[2,1-b]thiazole (mn2mt) and 3-methyl-6-(naphthalene-1-yl)imidazo[2,1-b]thiazole (mn1mt) as primary ligands, and picolinic acid (pic), isoquinoline-3-carboxylic acid (3-IQA), quinoline-2-carboxylic acid (2-QA), and 2-(pyridin-2-yl)phenol (hppy) as auxiliary ligands. The structures, photoluminescence, and electrochemical properties of the complexes were thoroughly investigated. Additionally, LEDs based on InGaN chip excitation showed good performance when using the synthesized IrIII complexes as emitters.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Gratal, Maria-Selma Arias-Perez, Lourdes Gude
Summary: In this study, a novel family of carbohydrate conjugates based on the 2-aryl-imidazo[4,5-f][1,10]phenanthroline core modified with carbohydrates (carb-APIPs) were presented. The carb-APIPs exhibited high affinity and selectivity towards telomeric G-quadruplex DNA structure, and showed significant cytotoxic properties in cancer cells.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Afaf Y. Khormi, Refat El-Sayed, Thoraya A. Farghaly, Mohamed R. Shaaban, Ahmad M. Farag
Summary: Combining fatty acids derived from oils and fats with heterocyclic compounds has made significant progress in the synthesis of valuable biologically active molecules in the pharmaceutical industry. This review provides a simple classification and organized presentation of the synthetic pathways for constructing fatty acid-heterocycle hybrids.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Chemistry, Organic
Jehan Y. Al-Humaidi, A. A. Nayl, Mohamed M. Abdalla, Sobhi M. Gomha
Summary: This study synthesized and tested the in-vivo activity of different compounds, and found that triazolo-tetrazine derivatives have excellent anticonvulsant and CNS-depressant activities. Further structure-activity relationship studies demonstrated that electron-releasing groups increase activity while electron-withdrawing groups decrease activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Sobhi M. Gomha, Sayed M. Riyadh, Thoraya A. Farghaly, Reda A. Haggam
Summary: This recent review highlights the synthetic utility of bis-(4-amino-5-mercapto[1,2,4] triazoles) as versatile building blocks for the synthesis of diverse bis-fused [1,2,4]triazoles and pharmacological polymeric materials. The synthesis of macrocycles containing [1,2,4]triazole subunits is also demonstrated. The review encompasses the period from 2000 to February 2022.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Thoraya A. Farghaly, Wedian A. Al-Hasani, Mona H. Ibrahim, Magda H. Abdellattif, Zeinab A. Abdallah
Summary: This study designed new 2-(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethylidene)hydrazineylidene)-2,5-dihydrothiazole compounds as CDK-2 inhibitors and evaluated their activity through in vitro experiments. Compound 11b showed strong inhibitory activity against cancer cells, especially against HEPG-2 liver cancer cells.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Review
Chemistry, Organic
Thoraya A. Farghaly, Sami A. Al-Hussain, Magdi E. A. Zaki, Nadia T. Al-Qurashi, Salwa S. Alharbi, Zeinab A. Muhammad
Summary: This review collects and categorizes spiropyrazoles based on their combined rings and illustrates different synthesis methods.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Ghada S. Masaret, Thoraya A. Farghaly, Sami A. Al-Hussain, Magdi E. A. Zaki, Amani M. R. Alsaedi, Zeinab A. Muhammad
Summary: In this study, the site-selectivity of the reaction between 3-amino-4-cyano-5-phenyl-1H-pyrrole-2-carboxylic acid amide 1 and different types of hydrazonoyl halides and alpha-haloketones was investigated. The resulting products were identified as pyrrolo[1,2-d][1,2,4]triazine and pyrrolo[1,2-a]pyrazine derivatives through spectral data and conformational studies. Docking studies were conducted to evaluate the ability of these newly synthesized derivatives to dock and inhibit microbes and COVID-19 proteins. The results showed a strong fit of the tested derivatives into the active sites of peroxiredoxin 5 and COVID-19 main protease. Additionally, the antimicrobial activity of the products was examined against fungi species and bacteria strains, with moderate activity observed against bacteria strains but no activity against fungi species.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Crystallography
Sobhi M. Gomha, Sayed M. Riyadh, Reem A. K. Alharbi, Magdi E. A. Zaki, Tariq Z. Abolibda, Basant Farag
Summary: A novel catalytic approach using cellulose sulfuric acid (CSA) as a green catalyst was developed for the synthesis of symmetric and asymmetric azines. The method showed high percentage yield, mild reaction conditions, broad substrate range, and environmentally benign characteristics, making it suitable for large-scale industrial manufacturing. Molecular docking analysis revealed the possible binding interactions between the azine derivatives and the target protein MAO-A, with some derivatives showing major conserved interactions, while others exhibited low binding activity.
Article
Chemistry, Physical
Abdulwahab Alamri, Ahmed Alafnan, Bader Huwaimel, Amr S. Abouzied, Jowaher Alanazi, Adel Alghamdi, Mohammad A. Alrofaidi, Muteb S. Alanazi, Ahmed Alshehri, Turki Al Hagbani, Ahmed Alobaida, Kareem M. Younes, Thoraya A. Farghaly
Summary: In the study, thiazole-linked-thiadiazole and dithiazole derivatives were synthesized and their antibacterial activity was tested. Three derivatives, 7d, 14c, and 14d, showed significant activity against Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). Moreover, compounds 7d, 14c, and 14d demonstrated potential anti-biofilm activity, with MSSA and MRSA being more sensitive than VRSA. Docking results also indicated that the dithiazole derivatives 14c and 14d showed good fitting and proper orientation into MRSA protein.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Adel Alghamdi, Amr S. S. Abouzied, Abdulwahab Alamri, Sirajudheen Anwar, Mukhtar Ansari, Ibrahim Khadra, Yasser H. H. Zaki, Sobhi M. M. Gomha
Summary: In this study, a novel series of N-aminothiazole-hydrazineethyl-pyridines were designed, synthesized, and characterized. Molecular docking and molecular dynamics simulation were applied to investigate their binding energy with the SARS-CoV-2 main protease. The results obtained from in vitro and in vivo research on these synthesized compounds are expected to make a significant contribution to the fight against COVID-19.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Refaie M. Kassab, Sami A. Al-Hussain, Aboubakr H. Abdelmonsef, Magdi E. A. Zaki, Sobhi M. Gomha, Zeinab A. Muhammad
Summary: A new series of xylenyl-spaced bis-carbazones were successfully synthesized and used as building blocks to construct a variety of bis-thiazole/thiazine derivatives. These newly synthesized compounds exhibited remarkable antiviral activity, especially compound 6d. Molecular docking study further confirmed the antiviral mechanism of these compounds.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sobhi M. Gomha, Magdi E. A. Zaki, Deepika Maliwal, Raghuvir R. S. Pissurlenkar, Mohamed S. Ibrahim, Maher Fathalla, Ahmed M. Hussein
Summary: This study synthesized novel 3-thiazolyl-indole derivatives and evaluated their ability to inhibit CDK2 using molecular docking analyses. The compounds exhibited significant inhibitory activity against CDK2 and showed potential as anticancer drugs.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Dina H. Dawood, Aladdin M. Srour, Mohamed A. Omar, Thoraya A. Farghaly, Riham A. El-Shiekh
Summary: This study designed and synthesized benzimidazole-thiazole hybrids as potential inhibitors for the treatment of Alzheimer's disease, showing dual inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Compound 4d demonstrated significant neuroprotective effects and may serve as a template for developing more potent inhibitors in the future.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Physical
Bakr F. Abdel-Wahab, Benson M. Kariuki, Hanan A. Mohamed, Mohamed S. Bekheit, Hanem M. Awad, Gamal A. El-Hiti
Summary: The synthesis of heterocycles containing 1,2,3-triazole and pyrazole moieties has been explored for their potential applications in the agrochemical and pharmaceutical fields. These heterocycles have shown promising anti-proliferation properties against cancer cells. In this study, several new 1H-1,2,3-triazole derivatives were successfully synthesized using simple procedures, and their activity against different types of cancer cells and normal cells was evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Ahmed Fawzy, Hatun H. Alsharief, Arafat Toghan, Areej Al Bahir, Mona Alhasani, Nada Alqarni, Amani M. R. Alsaedi, Thoraya A. Fargaly
Summary: In this study, three bis(3-schiff base-indoline-2-one) derivatives and two bis-spirotriazole-indole derivatives were synthesized and evaluated for their inhibition of aluminum corrosion in 1.0 M HCl. The results showed that the synthesized compounds were effective inhibitors, with inhibition efficiencies varying with concentration, structure, and corrosive medium concentration.
JOURNAL OF MOLECULAR STRUCTURE
(2023)