Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

(2019) Edith Emmings et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitohormesis Primes Tumor Invasion and Metastasis

(2019) Timothy C. Kenny et al.   Cell Reports

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

(2019) Meng Li et al.   CANCER CELL

The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right

(2019) Derek S Park et al.   CANCER RESEARCH

Ovarian cancer statistics, 2018

(2018) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State

(2018) Jue Hou et al.   CANCER RESEARCH

Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis

(2018) Yongping Zhou et al.   OncoTargets and Therapy

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

(2018) Zhen Wei et al.   Nature Communications

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

(2018) Beth L. Worley et al.   Redox Biology

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

(2017) T C Kenny et al.   ONCOGENE

Down-regulation of SIRT3 promotes ovarian carcinoma metastasis

(2016) Xue-cai Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells

(2016) Xi-Yan Xiang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

(2015) L. P. M. P. Hemachandra et al.   CANCER RESEARCH

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies

(2015) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

(2015) P. Rangarajan et al.   NEUROSCIENCE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients

(2015) Liane M. McGlynn et al.   PLoS One

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

(2014) Mohamed Mokhtar Desouki et al.   HUMAN PATHOLOGY

Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells

(2014) Q Cai et al.   ONCOGENE

Bioenergetic Analysis of Ovarian Cancer Cell Lines: Profiling of Histological Subtypes and Identification of a Mitochondria-Defective Cell Line

(2014) Usawadee Dier et al.   PLoS One

Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer

(2013) Bing Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

(2013) C. A. Davison et al.   CANCER RESEARCH

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis

(2012) Pachiyappan Kamarajan et al.   CANCER

BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation

(2012) Teresa M. Peart et al.   CLINICAL & EXPERIMENTAL METASTASIS

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids

(2011) Rohann J. M. Correa et al.   CARCINOGENESIS

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Intra-abdominal tumor dissemination pattern and surgical outcome in 214 patients with primary ovarian cancer

(2009) Jalid Sehouli et al.   JOURNAL OF SURGICAL ONCOLOGY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Altered redox status accompanies progression to metastatic human bladder cancer

(2008) N HEMPEL et al.   FREE RADICAL BIOLOGY AND MEDICINE