Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

(2018) Janneke F. Linnekamp et al.   CELL DEATH AND DIFFERENTIATION

Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells

(2018) Laia Caja et al.   ONCOGENE

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

(2017) Shazia Irshad et al.   JOURNAL OF PATHOLOGY

DNA Damage in Stem Cells

(2017) Ilio Vitale et al.   MOLECULAR CELL

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

(2017) Yu-Hua Zeng et al.   ONCOLOGY REPORTS

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

(2017) Zhen Qi et al.   Nature Communications

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Outcome From Oxaliplatin Treatment in Stage II/III Colon Cancer According to Intrinsic Subtypes

(2016) Nan Song et al.   JAMA Oncology

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology

(2015) Courtney M. Tate et al.   PLoS One

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

(2014) Ann Zeuner et al.   Cell Stem Cell

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells

(2012) C M Tate et al.   CELL DEATH AND DIFFERENTIATION

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

(2011) Aya Kobayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

Juvenile polyposis syndrome

(2011) Lodewijk AA Brosens   WORLD JOURNAL OF GASTROENTEROLOGY

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

(2010) Ylenia Lombardo et al.   GASTROENTEROLOGY

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

(2008) Liudmila L. Kodach et al.   GASTROENTEROLOGY

Expression and characterization of a human BMP-7 variant with improved biochemical properties

(2007) Bethany Swencki-Underwood et al.   PROTEIN EXPRESSION AND PURIFICATION