β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Resist or die: FOXO transcription factors determine the cellular response to chemotherapy

(2011) Ana R. Gomes et al.   CELL CYCLE

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

(2011) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Recent Developments in Anti-Cancer Agents Targeting PI3K, Akt and mTORC1/2

(2011) Rodrigo Dienstmann et al.   Recent Patents on Anti-Cancer Drug Discovery

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity

(2010) A Barbáchano et al.   ONCOGENE

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

(2010) Christophe Fuerer et al.   PLoS One

Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

(2010) Jie Chen et al.   PLoS One

FADD: a regulator of life and death

(2010) Léa Tourneur et al.   TRENDS IN IMMUNOLOGY

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

(2009) P. Storz et al.   MOLECULAR AND CELLULAR BIOLOGY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis

(2009) Susana Aguilar et al.   PLoS One

Discovery of Drug-Resistant and Drug-Sensitizing Mutations in the Oncogenic PI3K Isoform p110α

(2008) Eli R. Zunder et al.   CANCER CELL

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1

(2008) Manuel Dehner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

(2008) Héctor G. Pálmer et al.   PLoS One