Pioglitazone Attenuates Lipopolysaccharide-Induced Oxidative Stress, Dopaminergic Neuronal Loss and Neurobehavioral Impairment by Activating Nrf2/ARE/HO-1

Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3β in MPP+-Induced Cell Damage

(2019) Güliz Armagan et al.   MOLECULES

MiR‐21‐5p/dual‐specificity phosphatase 8 signalling mediates the anti‐inflammatory effect of haem oxygenase‐1 in aged intracerebral haemorrhage rats

(2019) Yetong Ouyang et al.   AGING CELL

Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control

(2018) Jeong-Min Hong et al.   LIFE SCIENCES

Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation

(2018) Rou-Ling Cho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPARγ/Nrf2/NF-κB signaling pathway

(2018) Qiaoling Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Arachidonic Acid Induces ARE/Nrf2-Dependent Heme Oxygenase-1 Transcription in Rat Brain Astrocytes

(2017) Chih-Chung Lin et al.   MOLECULAR NEUROBIOLOGY

Glitazone use associated with reduced risk of Parkinson's disease

(2017) Brage Brakedal et al.   MOVEMENT DISORDERS

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide

(2017) Eric E. Beier et al.   NEUROBIOLOGY OF DISEASE

Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation

(2017) Xiang-Jun Sheng et al.   PLoS One

Environmental conditions differentially affect neurobehavioral outcomes in a mouse model of sepsis-associated encephalopathy

(2017) Mu-Huo Ji et al.   Oncotarget

Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells

(2017) Sabrina Piras et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: a double-blind and placebo-controlled trial

(2016) Negar Iranpour et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1

(2016) Dan Li et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model

(2016) Chun-Yan Wang et al.   NEUROBIOLOGY OF AGING

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

(2015) Seán T. Anderson et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulation of the Nitrergic Pathway via Activation of PPAR-γ Contributes to the Neuroprotective Effect of Pioglitazone Against Streptozotocin-Induced Memory Dysfunction

(2015) Atish Prakash et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation

(2015) Kai Fan et al.   Journal of Neuroinflammation

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial

(2015)   LANCET NEUROLOGY

Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson’s Disease Through Upregulating Nrf2

(2015) Xu Jing et al.   NEUROCHEMICAL RESEARCH

Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents

(2015) Shuke Nie et al.   NEUROPHARMACOLOGY

A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats

(2015) Kristina Pilipović et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

(2015) Ruth Brauer et al.   PLOS MEDICINE

Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine

(2014) Janaína K. Barbiero et al.   BEHAVIOURAL BRAIN RESEARCH

Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation

(2014) Caroline André et al.   BRAIN BEHAVIOR AND IMMUNITY

Short-term effects of an endotoxin on substantia nigra dopamine neurons

(2014) Kaela R.S. Reinert et al.   BRAIN RESEARCH

Pleiotropic Role of PPARγin Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR, and NF-κB

(2014) Xiu-Rong Zhao et al.   CNS Neuroscience & Therapeutics

Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer's Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway

(2014) Xiao-Juan Chao et al.   CNS Neuroscience & Therapeutics

Activation of PPARγ attenuates LPS-induced acute lung injury by inhibition of HMGB1-RAGE levels

(2014) Guizuo Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

(2014) Juan Carlos Corona et al.   EXPERIMENTAL NEUROLOGY

Assessment of Blood-Brain Barrier Function and the Neuroinflammatory Response in the Rat Brain by Using Cerebral Open Flow Microperfusion (cOFM)

(2014) Arijit Ghosh et al.   PLoS One

Sulforaphane Protects Rodent Retinas against Ischemia-Reperfusion Injury through the Activation of the Nrf2/HO-1 Antioxidant Pathway

(2014) Hong Pan et al.   PLoS One

Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity

(2013) Qing He et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice

(2013) I. Pérez-de-Puig et al.   NEUROSCIENCE

Oxidative Stress Is Related to the Deleterious Effects of Heme Oxygenase-1 in anIn VivoNeuroinflammatory Rat Model

(2013) Claire Tronel et al.   Oxidative Medicine and Cellular Longevity

The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

(2013) Eun Jung Park et al.   PLoS One

Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor

(2012) Y Kurauchi et al.   BRITISH JOURNAL OF PHARMACOLOGY

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation

(2012) Kai Fan et al.   Journal of Neuroinflammation

Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum

(2012) A.L. Colín-González et al.   NEUROSCIENCE

Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1

(2012) JingYuan Wan et al.   PHYTOTHERAPY RESEARCH

PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

(2012) Simone Polvani et al.   PPAR Research

Metalloporphyrins – An Update

(2012) Stephanie Schulz et al.   Frontiers in Pharmacology

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

(2011) Christine R Swanson et al.   Journal of Neuroinflammation

HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells

(2011) So Youn Park et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

(2010) Shih-Ying Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Up-Regulation of Heme Oxygenase-1 Protects Against Cold Injury-Induced Brain Damage: A Laboratory-Based Study

(2010) Ruey-Horng Shih et al.   JOURNAL OF NEUROTRAUMA

Serum heme oxygenase-1 levels are increased in Parkinson’s disease but not in Alzheimer’s disease

(2009) I. Mateo et al.   ACTA NEUROLOGICA SCANDINAVICA

The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression

(2009) Shih-Ya Hung et al.   NEUROPHARMACOLOGY

The Ladder Rung Walking Task: A Scoring System and its Practical Application.

(2009) Gerlinde A. Metz et al.   Jove-Journal of Visualized Experiments

Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease

(2008) Pramod Kumar et al.   BEHAVIOURAL BRAIN RESEARCH

Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death

(2008) Hong-Suk Cho et al.   NEUROTOXICOLOGY