Inhibitors of Brassinosteroid Biosynthesis and Signal Transduction

Brassinosteroids facilitate xylem differentiation and wood formation in tomato

(2019) Jinsu Lee et al.   PLANTA

Enhanced brassinosteroid signaling intensity via SlBRI1 overexpression negatively regulates drought resistance in a manner opposite of that via exogenous BR application in tomato

(2019) Shuming Nie et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Brassinosteroids Affect the Symbiosis Between the AM Fungus Rhizoglomus irregularis and Solanaceous Host Plants

(2019) Lea von Sivers et al.   Frontiers in Plant Science

Assay for abscisic acid 8′-hydroxylase activity of cloned plant cytochrome P450 oxidases in Saccharomyces cerevisiae

(2018) Stella Eggels et al.   ANALYTICAL BIOCHEMISTRY

Brassinosteroids Dominate Hormonal Regulation of Plant Thermomorphogenesis via BZR1

(2018) Carla Ibañez et al.   CURRENT BIOLOGY

Interdependent Nutrient Availability and Steroid Hormone Signals Facilitate Root Growth Plasticity

(2018) Amar Pal Singh et al.   DEVELOPMENTAL CELL

Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis

(2018) Ji Hyun Youn et al.   JOURNAL OF EXPERIMENTAL BOTANY

BES1 and BZR1 Redundantly Promote Phloem and Xylem Differentiation

(2018) Masato Saito et al.   PLANT AND CELL PHYSIOLOGY

OUP accepted manuscript

(2018)   PLANT AND CELL PHYSIOLOGY

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

(2018) Justin M. Di Trani et al.   Nature Communications

PIF4‐induced BR synthesis is critical to diurnal and thermomorphogenic growth

(2018) Cristina Martínez et al.   EMBO JOURNAL

Application of Brassinosteroid Mimetics Improves Growth and Tolerance of Maize to Nicosulfuron Toxicity

(2018) Shaojin Liu et al.   JOURNAL OF PLANT GROWTH REGULATION

Overexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

(2018) Norma Fàbregas et al.   Nature Communications

Synthesis of Five Known Brassinosteroid Analogs from Hyodeoxycholic Acid and Their Activities as Plant-Growth Regulators

(2017) María Duran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of a nonsteroidal brassinolide-like compound, NSBR1

(2017) Airi Sugiura et al.   JOURNAL OF PESTICIDE SCIENCE

A Novel Bikinin Analogue for Arabidopsis and Rice with Superior Plant Growth-Promoting Activity

(2017) Shaojin Liu et al.   JOURNAL OF PLANT GROWTH REGULATION

Structure based in silico identification of potentially non-steroidal brassinosteroids mimics

(2017) Beilei Lei et al.   Molecular BioSystems

BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis

(2017) Hui Li et al.   Molecular Plant

Occurrence of brassinosteroids in non-flowering land plants, liverwort, moss, lycophyte and fern

(2017) Takao Yokota et al.   PHYTOCHEMISTRY

MLK1 and MLK2 Coordinate RGA and CCA1 Activity to Regulate Hypocotyl Elongation inArabidopsis thaliana

(2017) Han Zheng et al.   PLANT CELL

Rhizobial symbiosis alleviates polychlorinated biphenyls-induced systematic oxidative stress via brassinosteroids signaling in alfalfa

(2017) Xiaomi Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Structure-activity relationship of brassinosteroids and their agricultural practical usages

(2017) Jinna Liu et al.   STEROIDS

Enantioselective palladium-catalyzed diboration of 1,1-disubstituted allenes

(2017) Jiawang Liu et al.   Chemical Science

Brassinosteroids improve photosystem II efficiency, gas exchange, antioxidant enzymes and growth of cowpea plants exposed to water deficit

(2017) J. V. Lima et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana

(2017) Alayna M. George Thompson et al.   Scientific Reports

On the acquisition and analysis of microscale thermophoresis data

(2016) Thomas H. Scheuermann et al.   ANALYTICAL BIOCHEMISTRY

In silico exploration for agonists/antagonists of brassinolide

(2016) Seisuke Takimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Is lithium biologically an important or toxic element to living organisms? An overview

(2016) Babar Shahzad et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Oligomerization between BSU1 Family Members Potentiates Brassinosteroid Signaling in Arabidopsis

(2016) Eun-Ji Kim et al.   Molecular Plant

REPLY: Brassinosteroid Regulates Gibberellin Synthesis to Promote Cell Elongation in Rice: Critical Comments on Ross and Quittenden's Letter

(2016) Hongning Tong et al.   PLANT CELL

REPLY: Interaction Between Brassinosteroids and Gibberellins: Synthesis or Signaling? In Arabidopsis Both!

(2016) Simon J Unterholzner et al.   PLANT CELL

Lithium toxicity in plants: Reasons, mechanisms and remediation possibilities – A review

(2016) Babar Shahzad et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Brassinosteroids participate in the control of basal and acquired freezing tolerance of plants

(2016) Marina Eremina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Effect of Brassinosteroid and Gibberellin Biosynthesis Inhibitors on Growth of Rice Seedlings

(2016) Tadashi Matusmoto et al.   Rice Science

Role of brassinosteroid signaling in modulating Tobacco mosaic virus resistance in Nicotiana benthamiana

(2016) Xing-Guang Deng et al.   Scientific Reports

Ethylene and hydrogen peroxide are involved in brassinosteroid-induced salt tolerance in tomato

(2016) Tong Zhu et al.   Scientific Reports

Hormonal control of cold stress responses in plants

(2015) Marina Eremina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fenarimol, a Pyrimidine-Type Fungicide, Inhibits Brassinosteroid Biosynthesis

(2015) Keimei Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Rise and Fall of Oral Ketoconazole

(2015) Aditya K. Gupta et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Brassinosteroids Are Master Regulators of Gibberellin Biosynthesis in Arabidopsis

(2015) Simon J. Unterholzner et al.   PLANT CELL

UDP-Glucosyltransferase71C5, a Major Glucosyltransferase, Mediates Abscisic Acid Homeostasis in Arabidopsis

(2015) Zhen Liu et al.   PLANT PHYSIOLOGY

Effects of brassinosteroids on quality attributes and ethylene synthesis in postharvest tomato fruit

(2015) Tong Zhu et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

YCZ-18 Is a New Brassinosteroid Biosynthesis Inhibitor

(2015) Keimei Oh et al.   PLoS One

Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta

(2014) Wilfried Rozhon et al.   BMC PLANT BIOLOGY

The brassinosteroid chemical toolbox

(2014) Wim Dejonghe et al.   CURRENT OPINION IN PLANT BIOLOGY

BR-dependent phosphorylation modulates PIF4 transcriptional activity and shapes diurnal hypocotyl growth

(2014) Stella Bernardo-García et al.   GENES & DEVELOPMENT

H2O2 mediates the crosstalk of brassinosteroid and abscisic acid in tomato responses to heat and oxidative stresses

(2014) Jie Zhou et al.   JOURNAL OF EXPERIMENTAL BOTANY

Brassinosteroid Regulates Cell Elongation by Modulating Gibberellin Metabolism in Rice

(2014) Hongning Tong et al.   PLANT CELL

The bHLH Transcription Factor HBI1 Mediates the Trade-Off between Growth and Pathogen-Associated Molecular Pattern-Triggered Immunity in Arabidopsis

(2014) M. Fan et al.   PLANT CELL

Abscisic Acid Uridine Diphosphate Glucosyltransferases Play a Crucial Role in Abscisic Acid Homeostasis in Arabidopsis

(2014) T. Dong et al.   PLANT PHYSIOLOGY

Randomized, Double-Blind, Placebo-Controlled Trial of Spironolactone for Hypokalemia in Continuous Ambulatory Peritoneal Dialysis Patients

(2014) Somchai Yongsiri et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Interplay between phosphorylation and SUMOylation events determines CESTA protein fate in brassinosteroid signalling

(2014) Mamoona Khan et al.   Nature Communications

Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

(2014) Eunkyoo Oh et al.   eLife

Brassinosteroids promote Arabidopsis pollen germination and growth

(2014) Frank Vogler et al.   Plant Reproduction

Mapping a Disordered Portion of the Brz2001-Binding Site on a Plant Monooxygenase, DWARF4, Using a Quartz-Crystal Microbalance Biosensor-Based T7 Phage Display

(2013) Yoichi Takakusagi et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase

(2013) Ann Michelle Stanley Morrison et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and biological evaluation of novel azole derivatives as selective potent inhibitors of brassinosteroid biosynthesis

(2013) Kazuhiro Yamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Brassinolide-2,3-acetonide: A brassinolide-induced rice lamina joint inclination antagonist

(2013) Takuya Muto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Asymmetric synthesis and effect of absolute stereochemistry of YCZ-2013, a brassinosteroid biosynthesis inhibitor

(2013) Keimei Oh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Regulation of Brassinosteroid Biosynthesis in Arabidopsis

(2013) Yuhee Chung et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Brassinosteroid-regulated GSK3/Shaggy-like Kinases Phosphorylate Mitogen-activated Protein (MAP) Kinase Kinases, Which Control Stomata Development inArabidopsis thaliana

(2013) Mamoona Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Improved Simplified High-Sensitivity Quantification Method for Determining Brassinosteroids in Different Tissues of Rice and Arabidopsis

(2013) P. Xin et al.   PLANT PHYSIOLOGY

A chemical genetics approach reveals a role of brassinolide and cellulose synthase in hypocotyl elongation of etiolated Arabidopsis seedlings

(2013) I.-Ju Chen et al.   PLANT SCIENCE

Genetic Variation in Plant CYP51s Confers Resistance against Voriconazole, a Novel Inhibitor of Brassinosteroid-Dependent Sterol Biosynthesis

(2013) Wilfried Rozhon et al.   PLoS One

Structural basis for differential recognition of brassinolide by its receptors

(2013) Ji She et al.   Protein & Cell

Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens

(2012) Andrew G. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of novel brassinosteroid biosynthesis inhibitors based on the ketoconazole scaffold

(2012) Keimei Oh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CYP90A1/CPD, a Brassinosteroid Biosynthetic Cytochrome P450 ofArabidopsis, Catalyzes C-3 Oxidation

(2012) Toshiyuki Ohnishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of a putative Arabidopsis BAHD acyltransferase causes dwarfism that can be rescued by brassinosteroid

(2012) Mengjiao Wang et al.   JOURNAL OF EXPERIMENTAL BOTANY

Regulation of Brassinosteroid Biosynthesis and InactivationF

(2012) Baolin Zhao et al.   Journal of Integrative Plant Biology

Brassinosteroids Regulate the Differential Growth of Arabidopsis Hypocotyls through Auxin Signaling Components IAA19 and ARF7

(2012) Xiao-Yi Zhou et al.   Molecular Plant

BR Signal Influences Arabidopsis Ovule and Seed Number through Regulating Related Genes Expression by BZR1

(2012) Hui-Ya Huang et al.   Molecular Plant

Homeostasis of Brassinosteroids Regulated by DRL1, a Putative Acyltransferase in Arabidopsis

(2012) Wenjiao Zhu et al.   Molecular Plant

Synthesis of 2RS,4RS-1-[2-Phenyl-4-[2-(2-trifluromethoxy-phenoxy)-ethyl]-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole Derivatives as Potent Inhibitors of Brassinosteroid Biosynthesis

(2012) Kazuhiro Yamada et al.   MOLECULES

Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway

(2012) Tae-Wuk Kim et al.   NATURE

SPEECHLESS integrates brassinosteroid and stomata signalling pathways

(2012) Gustavo E. Gudesblat et al.   NATURE CELL BIOLOGY

Fluorescent castasterone reveals BRI1 signaling from the plasma membrane

(2012) Niloufer G Irani et al.   Nature Chemical Biology

Stress-Induced GSK3 Regulates the Redox Stress Response by Phosphorylating Glucose-6-Phosphate Dehydrogenase in Arabidopsis

(2012) S. Dal Santo et al.   PLANT CELL

Arabidopsis Ubiquitin Conjugase UBC32 Is an ERAD Component That Functions in Brassinosteroid-Mediated Salt Stress Tolerance

(2012) F. Cui et al.   PLANT CELL

Brassinosteroid is involved in strawberry fruit ripening

(2012) Ye-mao Chai et al.   PLANT GROWTH REGULATION

BAT1, a putative acyltransferase, modulates brassinosteroid levels in Arabidopsis

(2012) Sunhwa Choi et al.   PLANT JOURNAL

Genetic Evidence for the Reduction of Brassinosteroid Levels by a BAHD Acyltransferase-Like Protein in Arabidopsis

(2012) H. Roh et al.   PLANT PHYSIOLOGY

Propiconazole Is a Specific and Accessible Brassinosteroid (BR) Biosynthesis Inhibitor for Arabidopsis and Maize

(2012) Thomas Hartwig et al.   PLoS One

Arabidopsis PIZZA Has the Capacity to Acylate Brassinosteroids

(2012) Katja Schneider et al.   PLoS One

MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis

(2012) H. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of the UGT73C6 alters brassinosteroid glucoside formation in Arabidopsis thaliana

(2011) Sigrid Husar et al.   BMC PLANT BIOLOGY

Brassinosteroid perception in the epidermis controls root meristem size

(2011) Y. Hacham et al.   DEVELOPMENT

Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots

(2011) M.-P. Gonzalez-Garcia et al.   DEVELOPMENT

Dual Role of BKI1 and 14-3-3 s in Brassinosteroid Signaling to Link Receptor with Transcription Factors

(2011) Haijiao Wang et al.   DEVELOPMENTAL CELL

CESTA, a positive regulator of brassinosteroid biosynthesis

(2011) Brigitte Poppenberger et al.   EMBO JOURNAL

The CYP701B1 ofPhyscomitrella patensis anent-kaurene oxidase that resists inhibition by uniconazole-P

(2011) Sho Miyazaki et al.   FEBS LETTERS

The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2

(2011) Tae-Wuk Kim et al.   MOLECULAR CELL

Structural insight into brassinosteroid perception by BRI1

(2011) Ji She et al.   NATURE

Structural basis of steroid hormone perception by the receptor kinase BRI1

(2011) Michael Hothorn et al.   NATURE

PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1

(2011) Wenqiang Tang et al.   NATURE CELL BIOLOGY

Rice CYP734As function as multisubstrate and multifunctional enzymes in brassinosteroid catabolism

(2011) Tomoaki Sakamoto et al.   PLANT JOURNAL

Characterization of brassinosteroid-regulated proteins in a nuclear-enriched fraction of Arabidopsis suspension-cultured cells

(2011) Tomoaki Shigeta et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

The effect of low-dose spironolactone on resistant hypertension

(2010) Mette Engbaek et al.   Journal of the American Society of Hypertension

FERONIA Is a Key Modulator of Brassinosteroid and Ethylene Responsiveness in Arabidopsis Hypocotyls

(2010) Stephen D. Deslauriers et al.   Molecular Plant

Optimised expression and spectral analysis of the target enzyme CYP51 from Penicillium digitatum with possible new DMI fungicides

(2010) Jianhua Zhang et al.   PEST MANAGEMENT SCIENCE

ASKθ, a group-III Arabidopsis GSK3, functions in the brassinosteroid signalling pathway

(2010) Wilfried Rozhon et al.   PLANT JOURNAL

Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis

(2010) Benjamin Cole et al.   PLANT JOURNAL

Arabidopsis CYP72C1 is an atypical cytochrome P450 that inactivates brassinosteroids

(2010) Leeann E. Thornton et al.   PLANT MOLECULAR BIOLOGY

Antifungal Treatment of Small Animal Veterinary Patients

(2010) Daniel S. Foy et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole

(2010) Wei Shi et al.   ACS Medicinal Chemistry Letters

Chemical Inhibition of a Subset of Arabidopsis thaliana GSK3-like Kinases Activates Brassinosteroid Signaling

(2009) Bert De Rybel et al.   CHEMISTRY & BIOLOGY

A graphical method for determining inhibition constants

(2009) Masataka Yoshino et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Genome-Wide Analysis Revealed the Complex Regulatory Network of Brassinosteroid Effects in Photomorphogenesis

(2009) L.i. Song et al.   Molecular Plant

Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors

(2009) Tae-Wuk Kim et al.   NATURE CELL BIOLOGY

BIN2 Functions Redundantly with Other Arabidopsis GSK3-Like Kinases to Regulate Brassinosteroid Signaling

(2009) Z. Yan et al.   PLANT PHYSIOLOGY

Reactive Oxygen Species Are Involved in Brassinosteroid-Induced Stress Tolerance in Cucumber

(2009) X.-J. Xia et al.   PLANT PHYSIOLOGY

The primary signaling outputs of brassinosteroids are regulated by abscisic acid signaling

(2009) S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of brassinosteroid signaling in Arabidopsis

(2009) M.-H. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shooting control by brassinosteroids: metabolomic analysis and effect of brassinazole on Malus prunifolia, the Marubakaido apple rootstock

(2009) Adaucto B. Pereira-Netto et al.   TREE PHYSIOLOGY

Castasterone is a likely end product of brassinosteroid biosynthetic pathway in rice

(2008) Bo Kyung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brz220 Interacts with DWF4, a Cytochrome P450 Monooxygenase in Brassinosteroid Biosynthesis, and Exerts Biological Activity

(2008) Katsuhiko SEKIMATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Growth and photosynthetic pigments responses of two varieties of Catharanthus roseus to triadimefon treatment

(2008) Cheruth Abdul Jaleel et al.   COMPTES RENDUS BIOLOGIES

Sequential Transphosphorylation of the BRI1/BAK1 Receptor Kinase Complex Impacts Early Events in Brassinosteroid Signaling

(2008) Xiaofeng Wang et al.   DEVELOPMENTAL CELL

A role of brassinosteroids in early fruit development in cucumber

(2008) F. Q. Fu et al.   JOURNAL OF EXPERIMENTAL BOTANY

CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

(2008) Galina I. Lepesheva et al.   LIPIDS

Chemical Genetic Dissection of Brassinosteroid–Ethylene Interaction

(2008) Joshua M. Gendron et al.   Molecular Plant

Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyltransferase mutants of Arabidopsis thaliana

(2008) John V. Dean et al.   PHYSIOLOGIA PLANTARUM

Efficacy of Triazole-Based Fungicides for Fusarium Head Blight and Deoxynivalenol Control in Wheat: A Multivariate Meta-Analysis

(2008) P. A. Paul et al.   PHYTOPATHOLOGY

BSKs Mediate Signal Transduction from the Receptor Kinase BRI1 in Arabidopsis

(2008) W. Tang et al.   SCIENCE