Article
Neurosciences
Jueqiong Wang, Huanhuan Sun, Ruoyi Guo, Jiangyuan Guo, Xinyi Tian, Jinli Wang, Shichao Sun, Yusen Han, Ying Wang
Summary: Recent studies have shown that exosomes obtained from bone marrow mesenchymal stem cells (BMSCs) have promising therapeutic potential in treating multiple sclerosis (MS). This study investigated the mechanism of BMSC-exos containing miR-23b-3p in both LPS-stimulated BV2 microglia and an animal model for MS. The results demonstrated that BMSC-Exos containing miR-23b-3p reduced microglial pyroptosis and alleviated the severity of EAE, providing new insights into the therapeutic potential of BMSC-Exos for MS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Qian Liu, Yang Shen, Yifang Xiao, Hong Xiang, Ling Chu, Tiansheng Wang, Honghui Liu, Guolin Tan
Summary: miR-124-3p may attenuate type 2 inflammation in AR by regulating IL-4R alpha signaling and may be a promising new target in AR treatment.
INFLAMMATION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Ning Wang, Xuanchen Liu, Zhen Tang, Xinghui Wei, Hui Dong, Yichao Liu, Hao Wu, Zhigang Wu, Xiaokang Li, Xue Ma, Zheng Guo
Summary: This study found that exosomes derived from diabetes mellitus BMSCs had lower osteogenic potential in bone defect repair compared to exosomes derived from normal BMSCs. The study also found that the level of miR-140-3p was significantly altered in exosomes derived from BMSCs, ADSCs, and serum from DM rats. Upregulating miR-140-3p promoted the differentiation of DM BMSCs into osteoblasts.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Xuanyong Yang, Jiang Xu, Shihai Lan, Zhigao Tong, Kang Chen, Zhizheng Liu, Shan Xu
Summary: This study found that exosomes derived from BMSCs contained downregulated miR-133a-3p. Upregulation of miR-133a-3p reversed OGD/R-induced growth inhibition in SH-SY5Y cells and promoted cell proliferation by inhibiting apoptosis. Exosomal miR-133a-3p also reversed OGD/R-induced cell apoptosis by inhibiting autophagy. Experimental results showed that exosomal miR-133a-3p derived from BMSCs alleviated CI/R injury symptoms by targeting the DAPK2/Akt signaling pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ying Chen, Jihong Lin, Andrea Schlotterer, Luke Kurowski, Sigrid Hoffmann, Seddik Hammad, Steven Dooley, Malte Buchholz, Jiong Hu, Ingrid Fleming, Hans-Peter Hammes
Summary: miR-124 regulates retinal vasoregression and neuroretinal function in the PKD rat model by inhibiting microglial activation and polarization, reducing pericyte loss, and shifting microglial polarization from a proinflammatory phenotype to an anti-inflammatory phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Fang Cheng, Fuji Yang, Yanjin Wang, Jing Zhou, Hui Qian, Yongmin Yan
Summary: This study investigates the efficacy and underlying mechanisms of human umbilical cord-derived exosomes (MSC-ex) in LOXL2 inhibition of liver fibrosis. It was found that MSC-ex could suppress LOXL2 expression through exosomal miR-27b-3p-mediated YAP down-regulation, thus delaying the progression of CCl4-induced liver fibrosis. These findings improve our understanding of the role of MSC-ex in liver fibrosis alleviation and provide new opportunities for clinical treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luqun Liang, Chunxin Wo, Yao Yuan, Hongjuan Cao, Wanlin Tan, Xingcheng Zhou, Dan Wang, Rongyu Chen, Mingjun Shi, Fan Zhang, Ying Xiao, Lingling Liu, Yuxia Zhou, Tian Zhang, Yuanyuan Wang, Bing Guo
Summary: In this study, the researchers found that miR-124-3p plays a crucial role in DKD progression by regulating renal mitochondrial function. They discovered that miR-124-3p down-regulated FOXQ1, which in turn suppressed Sirt4 expression and led to mitochondrial dysfunction, promoting the development of DKD.
Article
Medicine, Research & Experimental
Jingyi Fan, Yusen Han, Huanhuan Sun, Shichao Sun, Ying Wang, Ruoyi Guo, Jiangyuan Guo, Xinyi Tian, Jinli Wang, Jueqiong Wang
Summary: This study found that exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) carrying miR-367-3p can inhibit ferroptosis in BV2 microglia and alleviate the severity of EAE by suppressing EZH2 expression. These findings suggest a potential role of miR-367-3p overexpression in the treatment of EAE.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaofei Xue, Wang Xi, Wei Li, Jian Xiao, Zhinong Wang, Yufeng Zhang
Summary: Previous studies have shown that hydrogen-rich saline can selectively scavenge free radicals and alleviate inflammatory response in myocardial ischemia/reperfusion injury. This study found that the protective effect of hydrogen-rich saline on ischemia/reperfusion injury may be associated with the miR-124-3p-calpain1 signaling pathway.
Article
Biochemistry & Molecular Biology
Mengqi Zhang, Qian Wu, Mimi Tang, Zhuohui Chen, Haiyue Wu
Summary: In this study, it was found that inhibition of miR-3613-3p can enhance the function of BMECs and reduce neuronal apoptosis under oxygen-glucose deprivation conditions. Additionally, interfering with miR-3613-3p expression in BMSCs can reduce its enrichment in exosomes and promote M2 polarization of microglia, thereby decreasing neuronal apoptosis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Cell & Tissue Engineering
Xiaotang Ma, Yan Wang, Yumeng Shi, Suqing Li, Jinhua Liu, Xiangyong Li, Wangtao Zhong, Qunwen Pan
Summary: This study investigates the role of MSC exosomes carrying miR-132-3p in rescuing cognition and memory deficit in vascular dementia mice. The results suggest that MSC exosomes and miR-132-3p promote the recovery of cognitive function by improving neuronal and synaptic dysfunction through activation of the Ras/Akt/GSK-3β pathway induced by downregulation of RASA1. These findings provide potential therapeutic targets for the treatment of vascular dementia.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ting-Yi Sun, Ya-Qi Li, Fu-Qian Zhao, Hai-Mei Sun, Yang Gao, Bo Wu, Shu Yang, Feng-Qing Ji, De-Shan Zhou
Summary: This study identifies new interactive epigenetic regulation patterns involved in intestinal barrier dysfunction and colitis in elderly populations, suggesting the synergistic effects of miR-1-3p and miR-124-3p on disrupting the intestinal barrier and promoting inflammatory bowel disease development in the elderly.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Shitao Zhang, Dong Dong, Yuan Zhang, Jia Wang, Lei Liu, Yulin Zhao
Summary: The study revealed that miR-124-3p modulates the development of allergic rhinitis by targeting DPP4. Upregulation of miR-124-3p alleviated nasal symptoms, reduced pathological changes and cell apoptosis, and lowered inflammation factor levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Editorial Material
Neurosciences
Dariusz Zurawek, Gustavo Turecki
Summary: In this study, Namkung et al. found that microRNA miR-124-3p is linked to shared polygenic risk scores between schizophrenia and bipolar disorder, and it increases the risk for common behavioral alterations in these two disorders through modulation of AMPA receptor neurotransmission.
Article
Clinical Neurology
Dong Wang, Yueshan Fan, Yibing Fan, Zengguang Wang, Liang Yang, Jinhao Huang, Chuang Gao, Zilong Zhao, Jianning Zhang, Rongcai Jiang
Summary: The percentage of monocytes in peripheral blood may be a convenient and effective indicator for predicting the outcome of CSDH in patients receiving conservative treatment. Patients with good outcomes had obviously lower circulating monocyte percentages in their peripheral blood counts throughout the treatment period, and the monocyte percentage was also significantly decreased in patients who responded well to atorvastatin combined with dexamethasone.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Xiangyang Xiong, Yan Zuo, Lu Cheng, Zhenyu Yin, Tianpeng Hu, Mengtian Guo, Zhaoli Han, Xintong Ge, Wenzhu Li, Yan Wang, Dong Wang, Conglin Wang, Lan Zhang, Yaodan Zhang, Qiang Liu, Fanglian Chen, Ping Lei
Summary: This study found that modafinil improves learning and memory, reduces inflammation, and inhibits neuronal pyroptosis. It also upregulates brain-derived neurotrophic factor and synaptic activity. These findings suggest that modafinil can alleviate cognitive decline following sleep deprivation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Tangtang Xiang, Dongyi Feng, Xinjie Zhang, Yupeng Chen, Hanhua Wang, Xuanhui Liu, Zhitao Gong, Jiangyuan Yuan, Mingqi Liu, Zhuang Sha, Chuanxiang Lv, Weiwei Jiang, Meng Nie, Yibing Fan, Di Wu, Shiying Dong, Jiancheng Feng, Eugene D. Ponomarev, Jianning Zhang, Rongcai Jiang
Summary: This study found that increased intracranial pressure significantly impacts the glymphatic-lymphatic fluid transport system (GLFTS), and this impact depends on the severity of the intracranial pressure. These findings have translational applications in the prevention and treatment of related neurological disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Immunology
Dong Wang, Shishuang Zhang, Xintong Ge, Zhenyu Yin, Meimei Li, Mengtian Guo, Tianpeng Hu, Zhaoli Han, Xiaodong Kong, Dai Li, Jing Zhao, Lu Wang, Qiang Liu, Fanglian Chen, Ping Lei
Summary: This study found that repetitive mild traumatic brain injury (rmTBI) leads to changes in biomarker levels related to ferroptosis, and treatment with mesenchymal stromal cells (MSCs) can alleviate neuronal damage and improve cognitive function caused by rmTBI, partially through inhibiting ferroptosis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Chuang Gao, Yingsheng Wei, Xinjie Zhang, Jinhao Huang, Meng Nie, Xuanhui Liu, Jiangyuan Yuan, Dong Wang, Ye Tian, Weiwei Jiang, Shuo An, Jian Sun, Zhuang Sha, Yibing Fan, Jiancheng Feng, Mingqi Liu, Shiying Dong, Di Wu, Jianning Zhang, Junping Wang, Rongcai Jiang
Summary: The objective of this study was to investigate the effects of craniocervical manual lymphatic drainage (cMLD) on hematoma absorption and the efficiency of atorvastatin-based conservative treatment in patients with chronic subdural hematoma (CSDH). The results showed that cMLD, combined with atorvastatin-based therapy, promoted hematoma absorption and reduced the need for surgery. The volume of the deep cervical lymphatic nodes (dCLNs) also significantly increased after 2 weeks of cMLD treatment. No severe side effects were reported.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Ying Jia, Yi-fan He, Ye Tian, Yuan-zhi Wang, Rui-ting Zhao, Xiao-chun Li, Jian Sun, Ying-sheng Wei, Shuo An, Heng-jie Yuan, Chun-xiao Wan, Rong-cai Jiang
Summary: Electrical stimulation of the right median nerve can aid in coma arousal after traumatic brain injury. This study investigated the efficacy of this stimulation and explored the mechanisms behind it. The results showed that patients who received right median nerve electrical stimulation experienced a more rapid increase in awareness and brain function. The analysis of microRNA expression revealed a relationship between differentially expressed microRNAs and neuronal growth, repair, and neural signal transmission. The pathways most correlated with these microRNAs were associated with tumor necrosis factor signaling and dopaminergic synapse.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Clinical Neurology
Tangtang Xiang, Xinjie Zhang, Yingsheng Wei, Dongyi Feng, Zhitao Gong, Xuanhui Liu, Jiangyuan Yuan, Weiwei Jiang, Meng Nie, Yibing Fan, Yupeng Chen, Jiancheng Feng, Shiying Dong, Chuang Gao, Jinhao Huang, Rongcai Jiang
Summary: This study reports three cases of SDH that may be associated with substandard cupping therapy and Intracranial Pressure Reduction (ICPR). The patients experienced severe headaches after the cup placed on the occipital-neck junction (ONJ) was suddenly removed during the last cupping procedure, and were diagnosed with SDH the next day. It is speculated that the repeated removal of cups on the soft tissue over the cisterna magna created localized negative pressure, causing temporary but repeated ICPR and eventually leading to SDH development. This case serves as a reminder for professional technicians to assess the patient's condition before cupping therapy and to ensure proper placement of the cups.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Ye Tian, Dong Wang, Xinjie Zhang, Huijie Wei, Yingsheng Wei, Shuo An, Chuang Gao, Jinhao Huang, Jian Sun, Rongcai Jiang, Jianning Zhang
Summary: A new prediction model for the self-absorption probability of chronic subdural hematoma (CSDH) was established and validated. The model showed good performance in both the initial data and external validation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Yibing Fan, Di Wu, Xinjie Zhang, Weiwei Jiang, Meng Nie, Xuanhui Liu, Tangtang Xiang, Mingqi Liu, Yupeng Chen, Dongyi Feng, Jinhao Huang, Chuang Gao, Rongcai Jiang
Summary: By comparing the data of CSDH patients and control individuals, it was found that the inflammatory markers of CSDH patients were significantly higher than those of the control group. After being cured, the number of inflammatory cells in patients decreased, suggesting the existence of a non-hematologic route for hematoma absorption.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Jixing Zhao, Shixue Yang, Xiaoteng Cui, Qixue Wang, Eryan Yang, Fei Tong, Biao Hong, Menglin Xiao, Lei Xin, Can Xu, Yanli Tan, Chunsheng Kang
Summary: Researchers have discovered a small-molecule inhibitor called EPIC-0412 that enhances the effectiveness of the chemotherapy drug TMZ in treating GBM. By disrupting DNA damage repair pathways and targeting MGMT, EPIC-0412 sensitizes GBM cells to TMZ and induces cell cycle arrest and apoptosis. The study also shows that EPIC-0412 epigenetically silences MGMT through specific pathways.
Editorial Material
Oncology
Xing Liu, Chunsheng Kang
Article
Geriatrics & Gerontology
Xintong Ge, Mengtian Guo, Meimei Li, Shishuang Zhang, Junlian Qiang, Luoyun Zhu, Lu Cheng, Wenzhu Li, Yan Wang, Jinwen Yu, Zhenyu Yin, Fanglian Chen, Wen Tong, Ping Lei
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts, which is common in elderly people, athletes of full contact sports, military personnel, and victims of domestic violence. A diagnostic framework for CTE was proposed in 2021, but the clinical diagnostic criteria still need to be refined and validated with in vivo biomarkers. Tianjin Medical University General Hospital has conducted an observational cohort study since 2021, identifying potential CTE biomarkers in blood and exosomes. These biomarkers may contribute to updating the consensus diagnostic criteria for CTE.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Lei Xin, Yanli Tan, Yuanxue Zhu, Xiaoteng Cui, Qixue Wang, Jixing Zhao, Shaohui Tian, Can Xu, Menglin Xiao, Biao Hong, Jianglong Xu, Xiaoye Yuan, Changsheng Wang, Chunsheng Kang, Chuan Fang
Summary: This study identified a potential small-molecule inhibitor, EPIC-0307, that selectively disrupted the PRADX-EZH2 interaction to upregulate expressions of tumor suppressor genes, thereby exerting its antitumor effects on GBM cells. EPIC-0307 treatment also increased the chemotherapeutic efficacy of TMZ by epigenetically downregulating DNA repair-associated genes and MGMT expression in GBM cells.
Review
Oncology
Xiaoteng Cui, Yunfei Wang, Junhu Zhou, Qixue Wang, Chunsheng Kang
Summary: Malignant gliomas are difficult to diagnose and treat due to their infiltrative growth pattern, rapid progression, and poor prognosis. Temozolomide (TMZ) is the only first-line chemotherapeutic drug for malignant gliomas that can cross the blood-brain barrier, but some patients are insensitive to TMZ and can develop acquired resistance during treatment.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Neurosciences
Mengtian Guo, Xintong Ge, Conglin Wang, Zhenyu Yin, Zexi Jia, Tianpeng Hu, Meimei Li, Dong Wang, Zhaoli Han, Lu Wang, Xiangyang Xiong, Fanglian Chen, Ping Lei
Summary: Genetically modified microglial exosomes showed potential therapeutic effects in reducing neuro-deficits and brain edema, improving blood-brain barrier integrity, and reducing neural cell death in intracerebral hemorrhage (ICH) mice. This provides a promising therapeutic strategy for improving neuroinflammation in ICH.
