The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis

The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function

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Association of Long-Chain Noncoding RNA H19 and MEG3 Gene Polymorphisms and Their Interaction with Risk of Osteoarthritis in a Chinese Han Population

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The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis

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The long noncoding RNA H19 attenuates force-driven cartilage degeneration via miR-483–5p/Dusp5

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Regulation of lncRNA-H19/miR-140-5p in cartilage matrix degradation and calcification in osteoarthritis

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LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p

(2019) Yafang Pan et al.   Cell Death & Disease

Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP‐2 and MMP‐9 via H19/miR‐29b‐3p and AKT/mTOR/autophagy signaling pathways

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The H19/let-7 feedback loop contributes to developmental dysplasia and dislocation of the hip

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Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation

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Restoration of osteochondral defects by implanting bilayered poly(lactide-co-glycolide) porous scaffolds in rabbit joints for 12 and 24 weeks

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Exosomes

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Mesenchymal Stem Cell Migration and Tissue Repair

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lnc-SAMD14-4 can regulate expression of the COL1A1 and COL1A2 in human chondrocytes

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Long non-coding RNA H19 modulates proliferation and apoptosis in osteoarthritis via regulating miR-106a-5p

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H19 lncRNA: Roles in tumorigenesis

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Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity

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Therapeutic Efficacy of Spherical Aggregated Human Bone Marrow–Derived Mesenchymal Stem Cells Cultured for Osteochondral Defects of Rabbit Knee Joints

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DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

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FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

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Osteochondral Allograft Transplantation of the Knee in Patients with an Elevated Body Mass Index

(2018) Dean Wang et al.   Cartilage

Cartilage Restoration: Microfracture and Osteochondral Autograft Transplantation

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Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility

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Cartilaginous extracellular matrix derived from decellularized chondrocyte sheets for the reconstruction of osteochondral defects in rabbits

(2018) Zhifa Wang et al.   Acta Biomaterialia

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MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

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MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes

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Early osteoarthritis of the knee

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The microRNA-29 family in cartilage homeostasis and osteoarthritis

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Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

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FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

(2014) Yukio Akasaki et al.   Arthritis & Rheumatology

FOXOs: signalling integrators for homeostasis maintenance

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Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

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Transcriptomic Analysis Identifies Foxo3A as a Novel Transcription Factor Regulating Mesenchymal Stem Cell Chrondrogenic Differentiation

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

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