Article
Immunology
Mandy I. Cheng, Joey H. Li, Luke Riggan, Bryan Chen, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O'Sullivan, Maureen A. Su
Summary: The outcomes of viral infections are influenced by sex, with males being more susceptible. Surprisingly, males have increased numbers of antiviral natural killer (NK) cells. However, these NK cells in males display decreased effector function compared to females in both mice and humans. The differences are not solely dependent on gonadal hormones and are associated with lower levels of UTX, an epigenetic regulator, in male NK cells. On the other hand, NK cell-intrinsic UTX deficiency in female mice increases NK cell numbers and reduces effector responses, leading to increased lethality to mouse cytomegalovirus.
Article
Multidisciplinary Sciences
Matan Sorek, Shelley L. Berger
Summary: Eusocial insects, such as ants, exhibit a system of division of labor within their colonies. This provides an opportunity to study the relationship between complex behaviors and their molecular mechanisms. Recent studies have experimentally altered ant behavior, revealing the involvement of neuromodulators and chromatin regulation in these behaviors. In this review, we discuss the current understanding and future directions in studying the relationship between neuromodulators, epigenetics, and social behavior in ants.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Editorial Material
Neurosciences
Giorgia Pedini, Claudia Bagni
Summary: Mutations in epigenetic factors are linked to autism spectrum disorder (ASD). In this Neuron paper, Yan et al. (2022) demonstrate that the antagonism between ASH1L and PRC2 alters the balance of histone methylation at the ephrin receptor A7 locus, resulting in decreased expression of EphA7, synaptic pruning deficits, and ASD-like behaviors.
Article
Cell Biology
Feiyu Tang, Can Lu, Xiang He, Wei Lin, Bowen Xie, Xing Gao, Yang Peng, Desong Yang, Lunquan Sun, Liang Weng
Summary: The E3 ligase Trim35 is identified as an effective biomarker for predicting the prognosis of LSD1-targeted therapy and immunotherapy. It represses the activity of LSD1 by mediating its ubiquitination, leading to increased T cell infiltration and tumor immunogenicity.
Article
Engineering, Environmental
Fuxiang Yang, Guoqing Zhang, Jinlong Liu, Shuanggang Duan, Lei Li, Yongyue Lu, Man-Qun Wang, Aiming Zhou
Summary: Cadmium contamination affects the chemosensory function of ants by altering the expression patterns of odor binding protein genes, resulting in impaired olfactory signal transduction and chemosensory dysfunction.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Entomology
Francesca Barbero, Giuseppe Mannino, Luca Pietro Casacci
Summary: Insects with highly structured societies rely on the coordination of individuals and the regulation of biogenic amines to achieve social behavior. This study reviews the potential role of biogenic amines in modulating insect social behavior, particularly in ants. It also provides an analysis of research trends and interests related to biogenic amines in social insects.
Review
Biochemistry & Molecular Biology
Yumin Wang, Yan Wang, Harsh Patel, Jichao Chen, Jinhua Wang, Zhe-Sheng Chen, Hongquan Wang
Summary: Divergent N-6-methyladenosine (m(6)A) modifications, mediated by m(6)A regulators, play a dynamic and reversible role in posttranscriptional RNA modifications. Aberrant m(6)A modifications are associated with cancer occurrence, development, progression, and prognosis. This review summarizes the current roles of m(6)A regulators in cancer and explores the epigenetic regulatory mechanisms of m(6)A regulators in cancer genesis.
Review
Biology
Krzysztof Miler, Filip Turza
Summary: This review focuses on the topic of ant rescue behavior, highlighting its importance and characteristics within the ant community. The review discusses the different research areas that have focused on rescue behavior, indicating that it is a widespread phenomenon among various ant species and there are still many unanswered questions.
Article
Biochemistry & Molecular Biology
Brent Y. Chick, Diana C. Hargreaves
Summary: Recent research reveals that the CoREST complex plays a crucial role in regulating the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data demonstrate that this resistance transition is associated with the functional retargeting of CoREST on chromatin, which occurs in coordination with cJUN and SWI/SNF (cBAF).
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Review
Cell Biology
Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian, Maryam Farzaneh
Summary: JMJD3 is a key histone demethylase that regulates H3K27me3 and plays a crucial role in stem cell fate determination during the process of cell reprogramming.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Medicine, Research & Experimental
Tianqi Ming, Qiu Tao, Shun Tang, Hui Zhao, Han Yang, Maolun Liu, Shan Ren, Haibo Xu
Summary: Cancer is still increasing globally and requires intense study on its pathogenic mechanism and effective therapy. Epigenetics, studying heritable changes in gene expression, plays a crucial role in the initiation and progression of various malignancies. Curcumin, a plant-derived polyphenolic compound with strong bioactivity, has potential value in cancer treatment. This review summarizes recent advances in the efficacy of curcumin on cancer and its epigenetic regulation, as well as discusses methods to improve the bioavailability of curcumin.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Jingli Lu, Yan Liang, Haiyang Meng, Ailing Zhang, Junjie Zhao, Chengliang Zhang
Summary: The article discusses the metabolic and epigenetic features of Treg cells, as well as the impact of metabolites on epigenetic changes in Treg cells, which in turn affect the activation, differentiation, and function of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang
Summary: A comprehensive understanding of the lineage specification of endothelial cells is crucial for cardiovascular regenerative medicine. Recent studies have revealed the preferential regulation of cell identity genes by unique epigenetic signatures. In this study, we investigated the epigenetic landscape of endothelial cell lineage and identified MECOM as a key regulator.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Summary: MLL/AF4 fusion gene defines a high-risk subtype of B-precursor acute lymphoblastic leukemia. Relapse can result in lineage switch to acute myeloid leukemia, which is associated with changes in chromatin accessibility and transcriptional programs. The altered expression and mutation of chromatin modifiers are recurrently associated with the relapsed myeloid phenotype, indicating disrupted epigenetic regulation drives and maintains lineage switching in MLL/AF4 leukemia.
Article
Biochemistry & Molecular Biology
Evan O. Paull, Alvaro Aytes, Sunny J. Jones, Prem S. Subramaniam, Federico M. Giorgi, Eugene F. Douglass, Somnath Tagore, Brennan Chu, Alessandro Vasciaveo, Siyuan Zheng, Roel Verhaak, Cory Abate-Shen, Mariano J. Alvarez, Andrea Califano
Summary: Using a network-based approach, 407 master regulator proteins were identified to canalize individual cancer samples into 112 transcriptionally distinct tumor subtypes. These proteins were organized into 24 pan-cancer master regulator block modules regulating key cancer hallmarks and predictive of patient outcome. Genomic alterations were predicted to induce aberrant MR activity, providing insight into mechanisms linking tumor genetics and transcriptional identity.
Article
Genetics & Heredity
Karl M. Glastad, Michael A. D. Goodisman, Soojin V. Yi, Brendan G. Hunt
G3-GENES GENOMES GENETICS
(2016)
Article
Evolutionary Biology
Sandra M. Rehan, Karl M. Glastad, Sarah P. Lawson, Brendan G. Hunt
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Evolutionary Biology
Karl M. Glastad, Samuel V. Arsenault, Kim L. Vertacnik, Scott M. Geib, Sasha Kay, Bryan N. Danforth, Sandra M. Rehan, Catherine R. Linnen, Sarah D. Kocher, Brendan G. Hunt
GENOME BIOLOGY AND EVOLUTION
(2017)
Article
Biochemical Research Methods
Ran Chao, Jing Liang, Ipek Tasan, Tong Si, Linyang Ju, Huimin Zhao
ACS SYNTHETIC BIOLOGY
(2017)
Article
Engineering, Environmental
Helen C. Poynton, Simone Hasenbein, Joshua B. Benoit, Maria S. Sepulveda, Monica F. Poelchau, Daniel S. T. Hughes, Shwetha C. Murali, Shuai Chen, Karl M. Glastad, Michael A. D. Goodisman, John H. Werren, Joseph H. Vineis, Jennifer L. Bowen, Markus Friedrich, Jeffery Jones, Hugh M. Robertson, Rene Feyereisen, Alexandra Mechler-Hickson, Nicholas Mathers, Carol Eunmi Lee, John K. Colbourne, Adam Biales, J. Spencer Johnston, Gary A. Wellborn, Andrew J. Rosendale, Andrew G. Cridge, Monica C. Munoz-Torres, Peter A. Bain, Austin R. Manny, Kaley M. Major, Faith N. Lambert, Chris D. Vulpe, Padrig Tuck, Bonnie J. Blalock, Yu-Yu Lin, Mark E. Smith, Hugo Ochoa-Acuna, Mei-Ju May Chen, Christopher P. Childers, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, HarshaVardhan Doddapanen, Kim C. Worley, Donna M. Muzny, Richard A. Gibbs, Stephen Richards
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Evolutionary Biology
Sandra M. Rehan, Karl M. Glastad, Michael A. Steffen, Cameron R. Fay, Brendan G. Hunt, Amy L. Toth
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Multidisciplinary Sciences
Karl M. Glastad, Kaustubh Gokhale, Jurgen Liebig, Michael A. D. Goodisman
SCIENTIFIC REPORTS
(2016)
Review
Biology
Samuel V. Arsenault, Karl M. Glastad, Brendan G. Hunt
CURRENT OPINION IN INSECT SCIENCE
(2019)
Article
Multidisciplinary Sciences
Lihong Sheng, Emily J. Shields, Janko Gospocic, Karl M. Glastad, Puttachai Ratchasanmuang, Arjun Raj, Shawn Little, Roberto Bonasio, Shelley L. Berger
Article
Genetics & Heredity
Karl M. Glastad, Linyang Ju, Shelley L. Berger
Summary: This study elucidates the role of epigenetic regulation in the plasticity of caste-specific behavior in the ant Camponotus floridanus. The interaction between tramtrack (ttk) and CoREST plays a key role in the differential gene expression between castes, with ttk binding correlating with neurogenic Notch signaling and hormonal function.
Article
Cell Biology
Lihong Sheng, Emily J. J. Shields, Janko Gospocic, Masato Sorida, Linyang Ju, China N. N. Byrns, Faith Carranza, Shelley L. L. Berger, Nancy Bonini, Roberto Bonasio
Summary: By studying the changes in the number and gene expression of ensheathing glia in Drosophila melanogaster brain, it is found that dysregulated ensheathing glia can lead to lipid droplet accumulation, cellular dysfunction, and death, affecting brain health and lifespan. Inhibition of apoptosis can restore the declining number of ensheathing glia with age, improve the neuro-motor performance of aged fruit flies and prolong lifespan. Furthermore, an expanded ensheathing glia population can prevent amyloid-beta accumulation in a fly model of Alzheimer's disease and delay the premature death of diseased animals. These findings highlight the vital role of ensheathing glia in regulating brain health and animal longevity.
Article
Biochemistry & Molecular Biology
Linyang Ju, Karl M. Glastad, Lihong Sheng, Janko Gospocic, Callum J. Kingwell, Shawn M. Davidson, Sarah D. Kocher, Roberto Bonasio, Shelley L. Berger
Summary: The blood-brain barrier (BBB) plays a significant role in regulating complex social behavior in ants by controlling the level of juvenile hormone entering the brain, which in turn affects gene expression and behavior.
Article
Biochemistry & Molecular Biology
Janko Gospocic, Emily J. Shields, Karl M. Glastad, Yanping Lin, Clint A. Penick, Hua Yan, Alexander S. Mikheyev, Timothy A. Linksvayer, Benjamin A. Garcia, Shelley L. Berger, Jurgen Liebig, Danny Reinberg, Roberto Bonasio