Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

(2019) Jerzy M. Dziekan et al.   Science Translational Medicine

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

(2018) Mikhail M. Savitski et al.   CELL

Modulation of Protein-Interaction States through the Cell Cycle

(2018) Lingyun Dai et al.   CELL

Pervasive Protein Thermal Stability Variation during the Cell Cycle

(2018) Isabelle Becher et al.   CELL

Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib

(2018) Teemu P Miettinen et al.   EMBO JOURNAL

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners’ Perspective

(2018) Kenneth M. Comess et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thermal Proteome Profiling allows Quantitative Assessment of Interactions between Tetrachloroethene Reductive Dehalogenase and Trichloroethene

(2018) Dominique Türkowsky et al.   Journal of Proteomics

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

(2018) Alireza Azimi et al.   Molecular Systems Biology

Thermal proteome profiling in bacteria: probing protein state in vivo

(2018) André Mateus et al.   Molecular Systems Biology

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

(2018) Chris Soon Heng Tan et al.   SCIENCE

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

(2016) Isabelle Becher et al.   Nature Chemical Biology

Functional Data Analysis

(2016) Jane-Ling Wang et al.   Annual Review of Statistics and Its Application

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

(2015) Kilian V M Huber et al.   NATURE METHODS

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

(2015) Friedrich B M Reinhard et al.   NATURE METHODS

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

(2015) Holger Franken et al.   Nature Protocols

Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT

(2014) Kevin K. K. Leung et al.   BIOCHEMISTRY

NQO2 Is a Reactive Oxygen Species Generating Off-Target for Acetaminophen

(2014) Teemu P. Miettinen et al.   MOLECULAR PHARMACEUTICS

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

A statistical framework for biomarker discovery in metabolomic time course data

(2011) Maurice Berk et al.   BIOINFORMATICS

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

(2009) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY